Protein Alignment Tg and Epb42

DIOPT Version :10

• Sequence 1: NP_609174.1
• Gene: Tg / 34093
• FlyBaseID: FBgn0031975
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_001102060.1
• Gene: Epb42 / 362202
• RGDID: 1305306
• Length: 689
• Species: Rattus norvegicus
• Alignment Length: 711
• Identity: 183/711 - (25%)
• Similarity: 316/711 - (44%)
• Gaps: 57/711 - (8%)

  Fly    54 LGVLKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFTVA-- 116
            |.:...|....:|::||||.    |.:.:.|::|||:.|.:.::|.   :|:...:|.:..||
  Rat     5 LSIKSCDFHAAENNKEHHTD----AISSQHLILRRGQSFTITLNFR---APAHIFLSALKKVALI 62

  Fly   117 --DDTKPSPGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWKLDIDT 179
              ...:||....| .|:.|   |..|||...|.|.:...:.|..|:.:..|....:..:.|.:..
  Rat    63 AQTGEQPSKTSKT-QAIFP---ISSLGDKKGWSAAVVERDAQHWTISVTTPVDAVIGHYSLLLQV 123

  Fly   180 KLLGDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVWKIGQ 244
                .|.:.|||. ...:|||||..||.|:|::..||.|||::....|:.|:.:.::...|..||
  Rat   124 ----SGKKQYPLG-QFTLLFNPWNRDDAVFLQNEVQRTEYVLNQDGFIYLGTADCIQEEPWDFGQ 183

  Fly   245 FERHVLECSLKVLGTVGRIPPAYRGDPVRVARALSALVNSVDDDGVLLGNWSEDFSGGVAPTKWT 309
            |||.|::.||.:|....::..  ...|..||..:.||::::....||..:.::....|....|..
  Rat   184 FERDVMDLSLNLLSVDKQVKD--WSQPAHVACIVGALLHALKKKSVLPISQTQAAQQGALLYKRR 246

  Fly   310 GSVEILQQFYKTQ-KSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTVDVFIDAN 373
            |||.||:|:...: :.|..:|.|.|:.|..|:.|.||||:|::|.:.||..|..||.||.:.:..
  Rat   247 GSVPILRQWLTGRGRPVYESQAWVFAAVACTVLRCLGIPARVVTTFDSAQGTNGSLLVDEYYNEE 311

  Fly   374 NKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVGPASVAAVK 438
            ..:........||.:....|.||.||||..|    :||||::..........:.......|.|||
  Rat   312 GLQNGEGQRGHIWVFQTSVECWMNRPDLSPG----YDGWQILHPRAPNGVGVLGSCNLVPVKAVK 372

  Fly   439 NGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAIGHLISTKAVLKWEREDITDTYK 503
            .||:........:||.|||..:.|:.....: |:|...:...:|:.||||.|.....||||..||
  Rat   373 EGDLQLDPAVPELFAAVNASCVVWKCCEDGK-LELTNSNRKNVGNSISTKVVGSDRCEDITQNYK 436

  Fly   504 HAERSEEERSTMLKALKQSRHAFSRYYLNDN--------------FNDIEFDMELKDDIKIGQSF 554
            :.|.|.:|:..:.:..|:      |..|.::              |.::.....|:.:.::
  Rat   437 YPEGSLQEKEVLERVQKE------RMKLGEDTCPPSCEPGDPLHLFLEVPSSQPLRGNGRL---- 491

  Fly   555 SVVLKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVRMEVIFEEYYDK 619
            ||.|......|....:.   |:..|:.|.||.|..:......|.|.|.....:...:.|..:...
  Rat   492 SVALINPTDKEKEVELV---IAAQALYYNGVLATGLWRQKQFLMLGPNQVLRLSTSLSFSCFEQN 553

  Fly   620 LSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQKELDVILRLENPLPIPLH 684
            .......:::|.|:.....:..:||:|..:.:|::..::.:.|...| .|...:|:.|.|..|:.
  Rat   554 PPENTFLRVTAMARHSHAGFSCFAQEDVVISRPNLVIEMPKRATQYQ-PLTASVRMHNSLDAPMQ 617

  Fly   685 KGVFTVEGPG-IEQPLKFKIAEIPVGGTAAATFKYTPPYAGRGTMLAKFTSKELDDVDGYR 744
            ..:.::.|.| |.:..::.:..:..|.:....|::||.:.|...:..:.......::.|:|
  Rat   618 NCIISIFGRGLIHREKRYGLGSVWPGSSLHTQFQFTPTHLGLQRLTVEVDCDMFQNLTGHR 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	58..180	CDD:459971	32/125 (26%)
		TGc	324..419	CDD:214673	34/94 (36%)
		Transglut_C	538..644	CDD:460002	17/105 (16%)
		Transglut_C	652..750	CDD:460002	18/94 (19%)
Epb42	NP_001102060.1	Transglut_N	8..124	CDD:459971	32/130 (25%)
		TGc	261..351	CDD:214673	34/93 (37%)
		Transglut_C	473..565	CDD:460002	16/98 (16%)
		Transglut_C	586..684	CDD:460002	18/94 (19%)