Protein Alignment Tg and TGM6

DIOPT Version :10

• Sequence 1: NP_609174.1
• Gene: Tg / 34093
• FlyBaseID: FBgn0031975
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_945345.2
• Gene: TGM6 / 343641
• HGNCID: 16255
• Length: 706
• Species: Homo sapiens
• Alignment Length: 740
• Identity: 233/740 - (31%)
• Similarity: 355/740 - (47%)
• Gaps: 92/740 - (12%)

  Fly    52 AVLGVLKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFTVA 116
            |.:.|.|||.....|...|||..:..    ..||||||:.|.|.:..:|.....:   ..|||:.
Human     2 AGIRVTKVDWQRSRNGAAHHTQEYPC----PELVVRRGQSFSLTLELSRALDCEE---ILIFTME 59

  Fly   117 DDTKPSPGHGTLNALVPHDGIDYLGDTLE----WGAGIESHEGQTLTVLIKPPSTCPVTEWKLDI 177
            ...:.|      .||  |....:....||    |.|..|:...:||||.:..|.:..:..:.|.|
Human    60 TGPRAS------EAL--HTKAVFQTSELERGEGWTAAREAQMEKTLTVSLASPPSAVIGRYLLSI 116

  Fly   178 --------DTKLLGDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNR 234
                    ..:.||:          ..:||||||.:|.|:|...::|:|||:.|:.:|:||....
Human   117 RLSSHRKHSNRRLGE----------FVLLFNPWCAEDDVFLASEEERQEYVLSDSGIIFRGVEKH 171

  Fly   235 LRPSVWKIGQFERHVLECSLKVLGTVGRIP-----PA----YRGDPVRVARALSALVNSVDDDGV 290
            :|...|..||||..:|...|.:|   .|.|     ||    .|.:|:.|.|.:||:|||.:|.||
Human   172 IRAQGWNYGQFEEDILNICLSIL---DRSPGHQNNPATDVSCRHNPIYVTRVISAMVNSNNDRGV 233

  Fly   291 LLGNWSEDFSGGVAPTKWTGSVEILQQFYKTQ-KSVKFAQCWNFSGVLTTIARSLGIPSRIITCY 354
            :.|.|...:.||.:|..|.|||.|||::.|.: |.||:.|||.|:|||.|:.|.|||.:|:::.:
Human   234 VQGQWQGKYGGGTSPLHWRGSVAILQKWLKGRYKPVKYGQCWVFAGVLCTVLRCLGIATRVVSNF 298

  Fly   355 SSAHDTQASLTVDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATP 419
            :|||||..:|:||.::|:..:.|:..|.||:||:|||||.|..|.|||    .:::||||:||||
Human   299 NSAHDTDQNLSVDKYVDSFGRTLEDLTEDSMWNFHVWNESWFARQDLG----PSYNGWQVLDATP 359

  Fly   420 QEASDNMYRVGPASVAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAIGHL 484
            ||.|:.::|.|||||.|::.||:....||.|||||||||.:.|.:: ..:..:.:..:|..||..
Human   360 QEESEGVFRCGPASVTAIREGDVHLAHDGPFVFAEVNADYITWLWH-EDESRERVYSNTKKIGRC 423

  Fly   485 ISTKAVLKWEREDITDTYKHAERSEEERSTMLKALKQ------------SRHAFSRYYLNDNFND 537
            ||||||....|.||||.||:.|.|.:||....||:.:            .|.|..|....|:..:
Human   424 ISTKAVGSDSRVDITDLYKYPEGSRKERQVYSKAVNRLFGVEASGRRIWIRRAGGRCLWRDDLLE 488

  Fly   538 ------IEFDMELKDDIKIGQSFSVVLKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFE 596
                  |....::.:...:|....:.|.::|.: ||.......:|...:|||.....|:......
Human   489 PATKPSIAGKFKVLEPPMLGHDLRLALCLANLT-SRAQRVRVNLSGATILYTRKPVAEILHESHA 552

  Fly   597 LELEPKSSDYVRMEVIFEEYYDKLSSQAAFQISAAAKVKD-----TDYDYYAQDDFRVRKPDIKF 656
            :.|.|:....:.:.:.:.:|.:.|:......::|...|..     .:.|...:|...::
Human   553 VRLGPQEEKRIPITISYSKYKEDLTEDKKILLAAMCLVTKGEKLLVEKDITLEDFITIK------ 611

  Fly   657 QLGEA--AIVAQKELDVILRLENPLPIPLHKGVFTVEGPG-IEQPLKFKIAEIPVGGTAAATFKY 718
            .||.|  .:....|:.|:    |||...:......|||.| :::.|...:..:.....|:..|..
Human   612 VLGPAMVGVAVTVEVTVV----NPLIERVKDCALMVEGSGLLQEQLSIDVPTLEPQERASVQFDI 672

  Fly   719 TPPYAGRGTMLAKFTSKELDDVDGY 743
            ||..:|...:.....|....|:.|:
Human   673 TPSKSGPRQLQVDLVSPHFPDIKGF 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	58..180	CDD:459971	35/133 (26%)
		TGc	324..419	CDD:214673	46/94 (49%)
		Transglut_C	538..644	CDD:460002	18/110 (16%)
		Transglut_C	652..750	CDD:460002	21/95 (22%)
TGM6	NP_945345.2	Transglut_N	7..119	CDD:459971	35/126 (28%)
		TGc	268..359	CDD:214673	46/94 (49%)
		Transglut_C	495..600	CDD:460002	17/105 (16%)
		Transglut_C	608..703	CDD:460002	21/100 (21%)