DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and TGM6

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_945345.2	Gene:	TGM6 / 343641	HGNCID:	16255	Length:	706	Species:	Homo sapiens

Alignment Length:	740	Identity:	233/740 - (31%)
Similarity:	355/740 - (47%)	Gaps:	92/740 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 AVLGVLKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFTVA 116
            |.:.|.|||.....|...|||..:..    ..||||||:.|.|.:..:|.....:   ..|||:.
Human     2 AGIRVTKVDWQRSRNGAAHHTQEYPC----PELVVRRGQSFSLTLELSRALDCEE---ILIFTME 59

  Fly   117 DDTKPSPGHGTLNALVPHDGIDYLGDTLE----WGAGIESHEGQTLTVLIKPPSTCPVTEWKLDI 177
            ...:.|      .||  |....:....||    |.|..|:...:||||.:..|.:..:..:.|.|
Human    60 TGPRAS------EAL--HTKAVFQTSELERGEGWTAAREAQMEKTLTVSLASPPSAVIGRYLLSI 116

  Fly   178 --------DTKLLGDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNR 234
                    ..:.||:          ..:||||||.:|.|:|...::|:|||:.|:.:|:||....
Human   117 RLSSHRKHSNRRLGE----------FVLLFNPWCAEDDVFLASEEERQEYVLSDSGIIFRGVEKH 171

  Fly   235 LRPSVWKIGQFERHVLECSLKVLGTVGRIP-----PA----YRGDPVRVARALSALVNSVDDDGV 290
            :|...|..||||..:|...|.:|   .|.|     ||    .|.:|:.|.|.:||:|||.:|.||
Human   172 IRAQGWNYGQFEEDILNICLSIL---DRSPGHQNNPATDVSCRHNPIYVTRVISAMVNSNNDRGV 233

  Fly   291 LLGNWSEDFSGGVAPTKWTGSVEILQQFYKTQ-KSVKFAQCWNFSGVLTTIARSLGIPSRIITCY 354
            :.|.|...:.||.:|..|.|||.|||::.|.: |.||:.|||.|:|||.|:.|.|||.:|:::.:
Human   234 VQGQWQGKYGGGTSPLHWRGSVAILQKWLKGRYKPVKYGQCWVFAGVLCTVLRCLGIATRVVSNF 298

  Fly   355 SSAHDTQASLTVDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATP 419
            :|||||..:|:||.::|:..:.|:..|.||:||:|||||.|..|.|||    .:::||||:||||
Human   299 NSAHDTDQNLSVDKYVDSFGRTLEDLTEDSMWNFHVWNESWFARQDLG----PSYNGWQVLDATP 359

  Fly   420 QEASDNMYRVGPASVAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAIGHL 484
            ||.|:.::|.|||||.|::.||:....||.|||||||||.:.|.:: ..:..:.:..:|..||..
Human   360 QEESEGVFRCGPASVTAIREGDVHLAHDGPFVFAEVNADYITWLWH-EDESRERVYSNTKKIGRC 423

  Fly   485 ISTKAVLKWEREDITDTYKHAERSEEERSTMLKALKQ------------SRHAFSRYYLNDNFND 537
            ||||||....|.||||.||:.|.|.:||....||:.:            .|.|..|....|:..:
Human   424 ISTKAVGSDSRVDITDLYKYPEGSRKERQVYSKAVNRLFGVEASGRRIWIRRAGGRCLWRDDLLE 488

  Fly   538 ------IEFDMELKDDIKIGQSFSVVLKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFE 596
                  |....::.:...:|....:.|.::|.: ||.......:|...:|||.....|:......
Human   489 PATKPSIAGKFKVLEPPMLGHDLRLALCLANLT-SRAQRVRVNLSGATILYTRKPVAEILHESHA 552

  Fly   597 LELEPKSSDYVRMEVIFEEYYDKLSSQAAFQISAAAKVKD-----TDYDYYAQDDFRVRKPDIKF 656
            :.|.|:....:.:.:.:.:|.:.|:......::|...|..     .:.|...:|...::
Human   553 VRLGPQEEKRIPITISYSKYKEDLTEDKKILLAAMCLVTKGEKLLVEKDITLEDFITIK------ 611

  Fly   657 QLGEA--AIVAQKELDVILRLENPLPIPLHKGVFTVEGPG-IEQPLKFKIAEIPVGGTAAATFKY 718
            .||.|  .:....|:.|:    |||...:......|||.| :::.|...:..:.....|:..|..
Human   612 VLGPAMVGVAVTVEVTVV----NPLIERVKDCALMVEGSGLLQEQLSIDVPTLEPQERASVQFDI 672

  Fly   719 TPPYAGRGTMLAKFTSKELDDVDGY 743
            ||..:|...:.....|....|:.|:
Human   673 TPSKSGPRQLQVDLVSPHFPDIKGF 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	36/134 (27%)
		TGc	324..419	CDD:214673	46/94 (49%)
		Transglut_C	538..644	CDD:279295	18/110 (16%)
		Transglut_C	652..750	CDD:279295	21/95 (22%)
TGM6	NP_945345.2	Transglut_N	5..117	CDD:279240	35/126 (28%)
		TGc	268..359	CDD:214673	46/94 (49%)
		Transglut_C	495..600	CDD:279295	17/105 (16%)
		Transglut_C	608..703	CDD:279295	21/100 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7675
eggNOG	1	0.900	-	-		E1_2CD5G
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920