DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and Tgm4

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_017168931.1	Gene:	Tgm4 / 331046	MGIID:	3027002	Length:	749	Species:	Mus musculus

Alignment Length:	724	Identity:	240/724 - (33%)
Similarity:	366/724 - (50%)	Gaps:	94/724 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 ASSAVLGVL---KVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAIS 110
            :|..||.||   .|::..:.|...||||.:..    :.||:|||:.|.||:..||...| :|.:.
Mouse    78 SSRCVLTVLIIYAVNVERKLNAAAHHTSEYQT----KKLVLRRGQIFTLKVILNRPLQP-QDELK 137

  Fly   111 FIFTVADDTKPSPGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWKL 175
            ..||......|     .:..|.|.......|    |...|....|..:.:.:...:...|..:|:
Mouse   138 VTFTSGQRDPP-----YMVELDPVTSYRSKG----WQVKIAKQSGVEVILNVISAADAVVGRYKM 193

  Fly   176 DIDTKLLGDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVW 240
            .::....|          ..|:||||||.||.|::...::|.||:::||..::.|...:::...|
Mouse   194 RVNEYKAG----------VFYLLFNPWCSDDSVFMASEEERAEYILNDTGYMYMGFAKQIKEKPW 248

  Fly   241 KIGQFERHVLECSLKVLGTVGRIPPAYRGDPVRVARALSALVNSVDDDGVLLGNWSEDFSGGVAP 305
            ..||||:|:|.|...:|   .::......:||.|:||:..::.:. :.|||:|||:.|::.|.||
Mouse   249 TFGQFEKHILSCCFNLL---FQLENNEMQNPVLVSRAICTMMCAA-NGGVLMGNWTGDYADGTAP 309

  Fly   306 TKWTGSVEILQQFYKTQKSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTVDVFI 370
            ..||.||.||||.|.|:..|::.|||.|||:|||..|::|||:|.:|.:.|||||:.:||||:::
Mouse   310 YVWTSSVPILQQHYVTRMPVRYGQCWVFSGILTTALRAVGIPARSVTNFESAHDTEKNLTVDIYL 374

  Fly   371 DANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVGPASVA 435
            |.:.|.:...|.||:||:|||.:.||:|.||   .|| :|||||:|:||||.||..:|.||:.:.
Mouse   375 DESGKTIPHLTKDSVWNFHVWTDAWMKRQDL---PHG-YDGWQVLDSTPQEISDGGFRTGPSPLT 435

  Fly   436 AVKNGDILRPFDGGFVFAEVNADKLYW--RYNGPSQPLKLLRKDTLAIGHLISTKAVLKWEREDI 498
            |::.|.|...:|..|||.|||.||..|  :.|...:...|:..:|.:||..||||.|.:..||||
Mouse   436 AIRQGLIQMKYDTTFVFTEVNGDKFIWLVKQNQEREKNILIAVETASIGKKISTKMVGENRREDI 500

  Fly   499 TDTYKHAERSEEERSTMLKAL-KQSRHAFSRYYLNDNFNDIEFDMELKDDIKIGQSFSVVLKVSN 562
            |..||..|.|.|||..|.||. |.|....:...||   |.::..: |::.:::|....:.:.:..
Mouse   501 TLQYKFPEGSPEERKVMAKASGKPSDDKLNSRTLN---NSLQISV-LQNSLELGAPIYLTITLKR 561

  Fly   563 KSESRTHMATGQ---ISCDAVL--YTG-----VGAVEVKTLGFELELEPKSSDYVRMEVIFEEYY 617
            |:      ||.|   |||...|  |||     :|.:: ||:....:   :|..::.|:..:  |.
Mouse   562 KT------ATPQNVNISCSLNLQTYTGNKKTNLGVIQ-KTVQIHGQ---ESRVFLTMDASY--YI 614

  Fly   618 DKLSSQ------AAFQISAAAKVKD------TD----YDYYAQDDFRVRKPDIKFQLGEAAIVAQ 666
            .||...      ..|.|   |::.|      ||    :.|.|   |.|..|    ..|:    .:
Mouse   615 YKLGMVDDEMVIGGFII---AEIVDSGERVATDTTLCFLYSA---FSVEMP----STGK----VK 665

  Fly   667 KELDVILRLENPLPIPLHKGVFTVEGPGIEQPLKFKIAEIPVGGTAAATFKYTPPYAGRGTMLAK 731
            :.|.:..:..|.|||||....|:||..|:.....::...:|.|.|.....:.||..||....:.|
Mouse   666 QPLVITSKFTNTLPIPLTNIKFSVESLGLANMKSWEQETVPPGKTITFQMECTPVKAGPQKFIVK 730

  Fly   732 FTSKELDDV 740
            |.|:::.:|
Mouse   731 FISRQVKEV 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	31/125 (25%)
		TGc	324..419	CDD:214673	48/94 (51%)
		Transglut_C	538..644	CDD:279295	28/131 (21%)
		Transglut_C	652..750	CDD:279295	24/89 (27%)
Tgm4	XP_017168931.1	Transglut_N	86..195	CDD:366347	30/122 (25%)
		TGc	327..419	CDD:214673	48/95 (51%)
		Transglut_C	653..749	CDD:366371	27/98 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850848
Domainoid	1	1.000	118	1.000	Domainoid score	I5823
eggNOG	1	0.900	-	-		E1_2CD5G
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	1	1.000	-	-		FOG0001456
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102867
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11931
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.740