DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and tgm2b

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_997821.2	Gene:	tgm2b / 323856	ZFINID:	ZDB-GENE-030131-2576	Length:	679	Species:	Danio rerio

Alignment Length:	728	Identity:	233/728 - (32%)
Similarity:	358/728 - (49%)	Gaps:	104/728 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 DLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNR-DYSPSKDAISFIFTVADDTKPSP 123
            ||..:.|:.:|||.    ....:.|:||||:.|.:.:..|. .|.|....|:    :..:|.|.|
Zfish     9 DLACKFNNTDHHTE----LNGTDRLIVRRGQAFTINLQLNSGSYQPGYSQIN----ITAETGPDP 65

  Fly   124 --GHGT-----LNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWKLDIDTKL 181
              .:||     |::.|         |:..|.|.:.|..|:::.:.|......|:..:.|.:|.:
Zfish    66 QQQYGTRAVFSLSSEV---------DSSCWSAAVSSPPGESVCLSICAAPDAPIGHYTLTLDER- 120

  Fly   182 LGDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVWKIGQFE 246
                     :.:...:|||||||.|.||:::.::..|||:....:|:||......|..|..||||
Zfish   121 ---------IQIQFILLFNPWCPLDVVYMDNEEKLAEYVLAQDGIIFRGDAGYPVPLAWNFGQFE 176

  Fly   247 RHVLECSLKVLGTVGRIPPAYRGDPVR----------VARALSALVNSVD-DDGVLLGNWSEDFS 300
            ..:|:...::|.    :.|.:|.:|.:          |.|.|||::||.| |.|||.|.|.:.|.
Zfish   177 EGILDACFRILD----MNPKHRRNPAKDCSGRRNVIYVTRVLSAMINSNDQDSGVLEGCWRDTFD 237

  Fly   301 GGVAPTKWTGSVEILQQFYKTQ-KSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASL 364
            |||:|..|.|||:||:.:.::. ..|::.|||.|:.|..|:||::|||.|::|.|.|||||.::|
Zfish   238 GGVSPMSWGGSVQILRTWDRSSCLPVRYGQCWVFAAVACTVARAVGIPCRVVTNYYSAHDTNSNL 302

  Fly   365 TVDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRV 429
            .::.:::...:...:.|.|.|||||.|.|.||.|.||..|    |||||..|.||||.|:.::..
Zfish   303 LIERYVNEKGEVDHSSTRDMIWNYHCWVESWMGRSDLPPG----FDGWQASDPTPQEKSEGVFCC 363

  Fly   430 GPASVAAVKNGDILRPFDGGFVFAEVNADKLYW--RYNGPSQPLKLLRKDTLAIGHLISTKAVLK 492
            ||..|.|:|.|::...:|..|||||||||.:|:  ..:|.::.:...:|    :|..||||:|.:
Zfish   364 GPVPVRAIKEGELTFKYDAPFVFAEVNADLVYFLKSKDGSTRKINYDQK----VGQKISTKSVGR 424

  Fly   493 WEREDITDTYKHAERSEEERSTMLKALKQSRHAFSRYYLNDNFN-DIEFDMELKDDIKIGQSFSV 556
            .||||||..||:.|.|.:||....||..|::      .|.:..| .:...::|...::.|..|.|
Zfish   425 DEREDITHLYKYPEGSADERRVFEKANHQNK------LLQEKQNTGLNITIKLSSGVRKGCDFDV 483

  Fly   557 VLKVSN--KSESRTHMATGQISCDAVLYTGVGAVEVKTLGFE----LELEPKSSDYVRMEVIFEE 615
            ...|:|  ..|.:..:.   .:..||.|.||...|   .||:    :||.|.....|.:.:.:.:
Zfish   484 FAIVTNGTAEEKKCRLV---FASRAVSYNGVIGRE---CGFKDLLNVELPPGGERKVPLRLNYSK 542

  Fly   616 YYDKLSSQAAFQISAAAKVKDTDYDYYAQD------DFRVRKPDIKFQ-LGEAAIVAQKELDVIL 673
            |.:.|:.....::.|..      .||..:|      |..:..|:||.: |||..  ..::|...|
Zfish   543 YCNNLTEDNLIRLGALL------IDYSTRDAIMAMRDIVLDDPEIKIRILGEPK--ENRKLAAEL 599

  Fly   674 RLENPLPIPLHKGVFTVE------GPGIEQPLKFKIAEIPVGGTAAATFKYTPPYAGRGTMLAKF 732
            .::||||..|....||:|      |..|...|.   :.|..|..|.|...:||..:|...:|..|
Zfish   600 TIQNPLPEALQSCCFTIEGANLTGGDSITHTLD---SSIEPGQEAKAKIYFTPTQSGLRKLLVDF 661

  Fly   733 TSKELDDVDGYRH 745
            .|.:|..|.|||:
Zfish   662 NSDKLGHVRGYRN 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	31/126 (25%)
		TGc	324..419	CDD:214673	42/94 (45%)
		Transglut_C	538..644	CDD:279295	24/111 (22%)
		Transglut_C	652..750	CDD:279295	34/101 (34%)
tgm2b	NP_997821.2	Transglut_N	4..118	CDD:279240	31/125 (25%)
		YebA	<254..361	CDD:224224	47/110 (43%)
		TGc	260..353	CDD:214673	42/96 (44%)
		Transglut_C	467..565	CDD:279295	24/109 (22%)
		Transglut_C	579..679	CDD:279295	34/101 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596881
Domainoid	1	1.000	99	1.000	Domainoid score	I6999
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.910