Protein Alignment Tg and Tgm6

DIOPT Version :10

• Sequence 1: NP_609174.1
• Gene: Tg / 34093
• FlyBaseID: FBgn0031975
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_808394.1
• Gene: Tgm6 / 241636
• MGIID: 3044321
• Length: 706
• Species: Mus musculus
• Alignment Length: 731
• Identity: 241/731 - (32%)
• Similarity: 360/731 - (49%)
• Gaps: 82/731 - (11%)

  Fly    56 VLKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFTVADDTK 120
            :.|||.....|...|||..:..:    .||||||:.|.|.:..:| ...|::|:  ||||  :|.
Mouse     6 ITKVDWQHSKNGAAHHTQDYPCS----ELVVRRGQLFSLTLDLSR-VLDSEEAL--IFTV--ETG 61

  Fly   121 PSPGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWKLDI-------- 177
            |..........|.......:|||  |.|..|.....|:||.:..||...:..:.|.:
Mouse    62 PHASEALHTKAVFQTAELEIGDT--WTAAKEEQTENTITVSLSSPSNAVIGRYLLSVRPSSRRKH 124

  Fly   178 -DTKLLGDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVWK 241
             |.||   |.        ..:|||||||:|.|:|:..::|:|||::|:.:|:||....:|...|.
Mouse   125 SDRKL---GQ--------FILLFNPWCPEDDVFLDSEEERQEYVLNDSGVIFRGVEKHIRAQGWN 178

  Fly   242 IGQFERHVLECSLKVLGTVGRIP-----PA----YRGDPVRVARALSALVNSVDDDGVLLGNWSE 297
            .||||..:|...|.:|   .|.|     ||    :|.|||.|.|.:||:|||.:|.||:.|.|..
Mouse   179 YGQFEEDILNICLSIL---DRSPSHQEDPATDVSHRHDPVYVTRIISAMVNSNNDRGVVQGQWQG 240

  Fly   298 DFSGGVAPTKWTGSVEILQQFYKTQ-KSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQ 361
            .:.||..|..|.|||.|||:::|.: |.||:.|||.|:||:.|:.|.|||.:|:::.::|||||.
Mouse   241 KYGGGTNPLNWRGSVAILQKWFKGRYKPVKYGQCWVFAGVMCTVLRCLGIATRVVSNFNSAHDTD 305

  Fly   362 ASLTVDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNM 426
            .:|:||.::|:..:.|:..|.||:||:|||||.|..|.|||    .::|||||:||||||.|:.|
Mouse   306 GNLSVDKYVDSYGRTLEDLTEDSMWNFHVWNESWFARQDLG----PSYDGWQVLDATPQEESEGM 366

  Fly   427 YRVGPASVAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAIGHLISTKAVL 491
            :|.|||||.|::.||:....||.|||||||||.:.|.::...:..::. .||..||..||||||.
Mouse   367 FRCGPASVTAIREGDVHLAHDGPFVFAEVNADYITWLWHEDKRRERVY-SDTKKIGRCISTKAVG 430

  Fly   492 KWEREDITDTYKHAERSEEERSTMLKALKQ--------SRHAFSRYYLNDNFNDIEFDMELKDDI 548
            ...|.|||..||:.|.|.:||....||:|:        .|....|..:...:.|...:...|..|
Mouse   431 SDSRVDITGLYKYPEGSRKERQVYSKAVKKLLSVEAWGRRRRIRRASVRGVWRDDLLEPVTKPSI 495

  Fly   549 K----------IGQSFSVVLKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKS 603
            .          :||...:.|.::|.: :|.......:|...:|||.....|:......::|.|..
Mouse   496 TGKFKVLEPPVLGQDLKLALCLTNLT-ARAQRVRVNVSGATILYTRKPVAEILRESHTVKLGPLE 559

  Fly   604 SDYVRMEVIFEEYYDKLSSQAAFQISAAAKVKD-----TDYDYYAQDDFRVRKPDIKFQLGEAAI 663
            ...:.:.:.:.:|...|:......::|...|..     .:.|...:|...::      .||.|.:
Mouse   560 EKKIPVTISYSQYKGDLTEDKKILLAAMCLVSKGEKLLVEKDITLEDFITIK------VLGPAVV 618

  Fly   664 VAQKELDVILRLENPLPIPLHKGVFTVEGPGIEQ-PLKFKIAEIPVGGTAAATFKYTPPYAGRGT 727
            .....::|:  :.|||...:...|..|||.|:.| .|..::..:.....|...|..||..:|...
Mouse   619 GVTVTVEVL--VINPLSESVKDCVLMVEGSGLLQGQLSIEVPSLQPQEKALIQFNITPSKSGPRQ 681

  Fly   728 MLAKFTSKELDDVDGY 743
            :.....|.:..|:.|:
Mouse   682 LQVDLVSSQFPDIKGF 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	58..180	CDD:459971	38/130 (29%)
		TGc	324..419	CDD:214673	46/94 (49%)
		Transglut_C	538..644	CDD:460002	19/120 (16%)
		Transglut_C	652..750	CDD:460002	22/93 (24%)
Tgm6	NP_808394.1	Transglut_N	7..117	CDD:459971	37/120 (31%)
		TGc	268..359	CDD:214673	46/94 (49%)
		Transglut_C	495..600	CDD:460002	17/105 (16%)
		Transglut_C	608..703	CDD:460002	22/98 (22%)