Protein Alignment Tg and Tgm3

DIOPT Version :10

• Sequence 1: NP_609174.1
• Gene: Tg / 34093
• FlyBaseID: FBgn0031975
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: XP_006499214.1
• Gene: Tgm3 / 21818
• MGIID: 98732
• Length: 704
• Species: Mus musculus
• Alignment Length: 715
• Identity: 246/715 - (34%)
• Similarity: 376/715 - (52%)
• Gaps: 50/715 - (6%)

  Fly    40 IPQGDKTDGASSAVLGVLKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSP 104
            :.:..:||..:.| |.:..|:..:..|...|||..|    :.:..:||||:|:.:.:..||....
Mouse     2 VVRSKRTDPDAEA-LQIQNVNWQVPMNRRAHHTDKF----SSQDSIVRRGQPWEIILVCNRSLES 61

  Fly   105 SKDAISFIFTVADDTKPSPGHGT-LNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTC 168
            .:| ::||.:    |.|.|.... ..|:....|    ..|..|.|.::::.|..|.:.|..|.:.
Mouse    62 GED-LNFIVS----TGPQPSESARTKAVFSISG----RSTGGWNAALKANSGNNLAIAIASPVSA 117

  Fly   169 PVTEWKLDIDTKLLGDGSRSYPLPLPIYV-LFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSY 232
            |:..:.|.::....|   |:..|.|..:: |||||...|.|::.:..:|:|||..|:.:|:.||.
Mouse   118 PIGLYTLSVEISSRG---RASSLKLGTFIMLFNPWLQADDVFMSNHAERQEYVEEDSGIIYVGST 179

  Fly   233 NRLRPSVWKIGQFERHVLECSLKVLG---TVGRIP---PAYRGDPVRVARALSALVNSVDDDGVL 291
            ||:....|..||||..:|..||.:|.   ...|.|   .|.|.||..|.|.|||::|..||:||:
Mouse   180 NRIGMVGWNFGQFEEDILNISLSILDRSLNFRRDPVTDVARRNDPKYVCRVLSAMINGNDDNGVI 244

  Fly   292 LGNWSEDFSGGVAPTKWTGSVEILQQFYKTQ-KSVKFAQCWNFSGVLTTIARSLGIPSRIITCYS 355
            .||||.:::|||.|..|.||||||:.:.|:. :.|:|.|||.|:|.|.|:.|.||:|||:||.::
Mouse   245 SGNWSGNYTGGVDPRTWNGSVEILKNWKKSGFRPVQFGQCWVFAGTLNTVLRCLGVPSRVITNFN 309

  Fly   356 SAHDTQASLTVDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQ 420
            |||||..:|:|||:.||....|: :.:||:||:|||||.|..|.|||    .|::||||:|||||
Mouse   310 SAHDTDRNLSVDVYYDAMGNPLE-KGSDSVWNFHVWNEGWFVRTDLG----PTYNGWQVLDATPQ 369

  Fly   421 EASDNMYRVGPASVAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAIGHLI 485
            |.|..:::.|||||.|:|.||:.|.||..|:|||||||::.|.||..:...|....||.:||..|
Mouse   370 ERSQGVFQCGPASVNAIKAGDVDRNFDMIFIFAEVNADRITWIYNNRNNTQKQNSVDTHSIGKYI 434

  Fly   486 STKAVLKWEREDITDTYKHAERSEEERSTMLKALKQ-----------SRHAFSRYYLNDNFNDIE 539
            |||||....|.|:||.||:.|.|.|||....|||.:           ||:...    .|....|.
Mouse   435 STKAVGSNSRMDVTDKYKYPEGSSEERQVHQKALDKLKPNASFGATSSRNPEG----EDKEPSIS 495

  Fly   540 FDMELKDDIKIGQSFSVVLKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSS 604
            ...::...:.:|:..|:.|.:.|.:..| ...|..::...::|.|....||......:.|:|:..
Mouse   496 GKFKVTGILAVGKEVSLSLMLKNMTNDR-KTVTMNMTAWTIVYNGTLVHEVWKDSATISLDPEEE 559

  Fly   605 DYVRMEVIFEEYYDKLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQKEL 669
            ....:::.:.:|...|.:....:|:|..||.| :.:...:.|..:..|.:..::.|.|.| :|.:
Mouse   560 IQYPVKIAYSQYERYLKADNMIRITAVCKVPD-EAEVVVERDVILDNPALTLEVLEQAHV-RKPV 622

  Fly   670 DVILRLENPLPIPLHKGVFTVEGPG-IEQPLKFKIAEIPVGGTAAATFKYTPPYAGRGTMLAKFT 733
            :|.:...|||..|::..|..|||.| :...||..:..:.....:...|:..|..:|...:||.|:
Mouse   623 NVQMLFSNPLDQPVNNCVLLVEGSGLLRGSLKIDVPSLRPKEKSRIRFEIFPTRSGTKQLLADFS 687

  Fly   734  733
            Mouse   688  687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	58..180	CDD:459971	30/122 (25%)
		TGc	324..419	CDD:214673	50/94 (53%)
		Transglut_C	538..644	CDD:460002	20/105 (19%)
		Transglut_C	652..750	CDD:460002	23/83 (28%)
Tgm3	XP_006499214.1	Transglut_N	18..129	CDD:459971	30/123 (24%)
		TGc	276..368	CDD:214673	50/96 (52%)
		Transglut_C	494..599	CDD:460002	20/106 (19%)
		Transglut_C	606..702	CDD:460002	23/83 (28%)