DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and Tgm3

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_006499214.1	Gene:	Tgm3 / 21818	MGIID:	98732	Length:	704	Species:	Mus musculus

Alignment Length:	715	Identity:	246/715 - (34%)
Similarity:	376/715 - (52%)	Gaps:	50/715 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 IPQGDKTDGASSAVLGVLKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSP 104
            :.:..:||..:.| |.:..|:..:..|...|||..|    :.:..:||||:|:.:.:..||....
Mouse     2 VVRSKRTDPDAEA-LQIQNVNWQVPMNRRAHHTDKF----SSQDSIVRRGQPWEIILVCNRSLES 61

  Fly   105 SKDAISFIFTVADDTKPSPGHGT-LNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTC 168
            .:| ::||.:    |.|.|.... ..|:....|    ..|..|.|.::::.|..|.:.|..|.:.
Mouse    62 GED-LNFIVS----TGPQPSESARTKAVFSISG----RSTGGWNAALKANSGNNLAIAIASPVSA 117

  Fly   169 PVTEWKLDIDTKLLGDGSRSYPLPLPIYV-LFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSY 232
            |:..:.|.::....|   |:..|.|..:: |||||...|.|::.:..:|:|||..|:.:|:.||.
Mouse   118 PIGLYTLSVEISSRG---RASSLKLGTFIMLFNPWLQADDVFMSNHAERQEYVEEDSGIIYVGST 179

  Fly   233 NRLRPSVWKIGQFERHVLECSLKVLG---TVGRIP---PAYRGDPVRVARALSALVNSVDDDGVL 291
            ||:....|..||||..:|..||.:|.   ...|.|   .|.|.||..|.|.|||::|..||:||:
Mouse   180 NRIGMVGWNFGQFEEDILNISLSILDRSLNFRRDPVTDVARRNDPKYVCRVLSAMINGNDDNGVI 244

  Fly   292 LGNWSEDFSGGVAPTKWTGSVEILQQFYKTQ-KSVKFAQCWNFSGVLTTIARSLGIPSRIITCYS 355
            .||||.:::|||.|..|.||||||:.:.|:. :.|:|.|||.|:|.|.|:.|.||:|||:||.::
Mouse   245 SGNWSGNYTGGVDPRTWNGSVEILKNWKKSGFRPVQFGQCWVFAGTLNTVLRCLGVPSRVITNFN 309

  Fly   356 SAHDTQASLTVDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQ 420
            |||||..:|:|||:.||....|: :.:||:||:|||||.|..|.|||    .|::||||:|||||
Mouse   310 SAHDTDRNLSVDVYYDAMGNPLE-KGSDSVWNFHVWNEGWFVRTDLG----PTYNGWQVLDATPQ 369

  Fly   421 EASDNMYRVGPASVAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAIGHLI 485
            |.|..:::.|||||.|:|.||:.|.||..|:|||||||::.|.||..:...|....||.:||..|
Mouse   370 ERSQGVFQCGPASVNAIKAGDVDRNFDMIFIFAEVNADRITWIYNNRNNTQKQNSVDTHSIGKYI 434

  Fly   486 STKAVLKWEREDITDTYKHAERSEEERSTMLKALKQ-----------SRHAFSRYYLNDNFNDIE 539
            |||||....|.|:||.||:.|.|.|||....|||.:           ||:...    .|....|.
Mouse   435 STKAVGSNSRMDVTDKYKYPEGSSEERQVHQKALDKLKPNASFGATSSRNPEG----EDKEPSIS 495

  Fly   540 FDMELKDDIKIGQSFSVVLKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSS 604
            ...::...:.:|:..|:.|.:.|.:..| ...|..::...::|.|....||......:.|:|:..
Mouse   496 GKFKVTGILAVGKEVSLSLMLKNMTNDR-KTVTMNMTAWTIVYNGTLVHEVWKDSATISLDPEEE 559

  Fly   605 DYVRMEVIFEEYYDKLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQKEL 669
            ....:::.:.:|...|.:....:|:|..||.| :.:...:.|..:..|.:..::.|.|.| :|.:
Mouse   560 IQYPVKIAYSQYERYLKADNMIRITAVCKVPD-EAEVVVERDVILDNPALTLEVLEQAHV-RKPV 622

  Fly   670 DVILRLENPLPIPLHKGVFTVEGPG-IEQPLKFKIAEIPVGGTAAATFKYTPPYAGRGTMLAKFT 733
            :|.:...|||..|::..|..|||.| :...||..:..:.....:...|:..|..:|...:||.|:
Mouse   623 NVQMLFSNPLDQPVNNCVLLVEGSGLLRGSLKIDVPSLRPKEKSRIRFEIFPTRSGTKQLLADFS 687

Fly 734 733
Mouse 688 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	30/123 (24%)
		TGc	324..419	CDD:214673	50/94 (53%)
		Transglut_C	538..644	CDD:279295	20/105 (19%)
		Transglut_C	652..750	CDD:279295	23/83 (28%)
Tgm3	XP_006499214.1	Transglut_N	15..129	CDD:366347	31/126 (25%)
		TGc	276..368	CDD:214673	50/96 (52%)
		Transglut_C	494..599	CDD:366371	20/106 (19%)
		Transglut_C	606..702	CDD:366371	23/83 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I7154
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020