Protein Alignment Tg and Tgm1

DIOPT Version :10

• Sequence 1: NP_609174.1
• Gene: Tg / 34093
• FlyBaseID: FBgn0031975
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_064368.3
• Gene: Tgm1 / 21816
• MGIID: 98730
• Length: 815
• Species: Mus musculus
• Alignment Length: 771
• Identity: 281/771 - (36%)
• Similarity: 410/771 - (53%)
• Gaps: 60/771 - (7%)

  Fly     7 CCQKC-----GDWKWCTSKDNEESTLRIRNANA------------NYFTGI-PQGDKTDGASSAV 53
            ||..|     ||..|    ..|.|..|.|..::            :..:|: ..||.|  ....:
Mouse    50 CCGCCSCGNRGDDDW----GPEPSGSRSRGTSSRGRDSRGGRRPESRGSGVNAAGDGT--IREGM 108

  Fly    54 LGVLKVDLCL---EDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFTV 115
            |.|..|||..   :.|..||||..|    ..:.|:||||:||.:.:..||:|. |.|.|:....:
Mouse   109 LVVTGVDLLCSRSDQNRREHHTDEF----EYDELIVRRGQPFHMILFLNREYE-SSDRIALELLI 168

  Fly   116 ADDTKPSPGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWKLDIDTK 180
            .  :.|..|.|| :.::|..    .|.:..|.|.:..:.|..|.:.:.......:.:::..:.|:
Mouse   169 G--SNPEVGKGT-HVIIPVG----KGGSGGWKAQVTKNNGHNLNLRVHTSPNAIIGKFQFTVRTR 226

  Fly   181 LLGDGSRSYPLPL----PIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVWK 241
               ..:..:.||.    .||:|||||||:|.||::..|.|:|||::::..|:.|:..::....|.
Mouse   227 ---SEAGEFQLPFDPRNEIYILFNPWCPEDIVYVDHEDWRQEYVLNESGRIYYGTEAQIGERTWN 288

  Fly   242 IGQFERHVLECSLKVLGTVGRIPPAYRGDPVRVARALSALVNSVDDDGVLLGNWSEDFSGGVAPT 306
            .|||:..||:..|.:|...| :|...|||||.|:|.:||:|||:||:|||:|||:.|:|.|..|:
Mouse   289 YGQFDHGVLDACLYILDRRG-MPYGGRGDPVSVSRVVSAMVNSLDDNGVLIGNWTGDYSRGTNPS 352

  Fly   307 KWTGSVEILQQFYKTQKSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTVDVFID 371
            .|.||||||..:.:|..||.:.|||.|:||.||:.|.||..:|.:|.::|||||..|||:|::.|
Mouse   353 AWVGSVEILLSYLRTGYSVPYGQCWVFAGVTTTVLRCLGFATRTVTNFNSAHDTDTSLTMDIYFD 417

  Fly   372 ANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVGPASVAA 436
            .|.|.|:....||:||:||||:.||:||||..|    |||||||||||||.|..::..||.||.:
Mouse   418 ENMKPLEHLNHDSVWNFHVWNDCWMKRPDLPSG----FDGWQVVDATPQETSSGIFCCGPCSVES 478

  Fly   437 VKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAIGHLISTKAVLKWEREDITDT 501
            ||||.:...:|..|:|||||:||:||:...... .|::..:..|||.||.|||:....|||||..
Mouse   479 VKNGLVYMKYDTPFIFAEVNSDKVYWQRQDDGS-FKIVYVEEKAIGTLIVTKAIHSNNREDITHI 542

  Fly   502 YKHAERSEEERSTMLKALKQSRHAFSRYYLNDNFNDIEFDMELKDDIKIGQSFSVVLKVSNKSES 566
            |||.|.||.||..:.||....... :.|...|:..|:...:|.:|.: :||..:|.:.::|:..|
Mouse   543 YKHPEGSEAERRAVEKAAAHGSKP-NVYATRDSAEDVAMQVEAQDAV-MGQDLAVSVVLTNRGSS 605

  Fly   567 RTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVRMEVIFEEYYDKLSSQAAFQISAA 631
            |..:......| ...||||.....|....|:.|.|.:||.|.|.|.::||...|..|.|..::.:
Mouse   606 RRTVKLHLYLC-VTYYTGVSGPTFKEAKKEVTLAPGASDSVTMPVAYKEYKPHLVDQGAMLLNVS 669

  Fly   632 AKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQKELDVILRLENPLPIPLHKGVFTVEGPGIE 696
            ..||::......|..||:|.||:...|..||:|.| |..|.:..:||||:.|...||.:||.|::
Mouse   670 GHVKESGQVLAKQHTFRLRTPDLSLTLLGAAVVGQ-ECGVQIVFKNPLPVTLTNVVFRLEGSGLQ 733

  Fly   697 QPLKFKIAEIPVGGTAAATFKYT--PPYAGRGTMLAKFTSKELDDVDGYRHYEIEP 750
            :|....:.:|  ||....|.:.|  |...|...::|...|.:|..|.|....::.|
Mouse   734 RPKVLNVGDI--GGNETVTLRQTFVPVRPGPRQLIASLDSPQLSQVHGVIQVDVAP 787

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	58..180	CDD:459971	32/124 (26%)
		TGc	324..419	CDD:214673	52/94 (55%)
		Transglut_C	538..644	CDD:460002	29/105 (28%)
		Transglut_C	652..750	CDD:460002	32/99 (32%)
Tgm1	NP_064368.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..48
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	62..101		6/42 (14%)
		Transglut_N	114..226	CDD:459971	32/123 (26%)
		TGc	370..461	CDD:214673	52/94 (55%)
		Transglut_C	578..682	CDD:460002	29/105 (28%)
		Transglut_C	690..787	CDD:460002	32/99 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..815