Protein Alignment Tg and F13A1

DIOPT Version :10

• Sequence 1: NP_609174.1
• Gene: Tg / 34093
• FlyBaseID: FBgn0031975
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_000120.2
• Gene: F13A1 / 2162
• HGNCID: 3531
• Length: 732
• Species: Homo sapiens
• Alignment Length: 726
• Identity: 248/726 - (34%)
• Similarity: 377/726 - (51%)
• Gaps: 68/726 - (9%)

  Fly    54 LGVLKVDLCLE---DNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFTV 115
            |.|..|.|..|   .|..:|||..:    ....|:||||:.|.::|.|:|.|.|.:|.....:.:
Human    46 LNVTSVHLFKERWDTNKVDHHTDKY----ENNKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVI 106

  Fly   116 ADDTKPSPGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWKL----- 175
            .  ..|....||   .:|...:..| .:.:|||.|...|.:::.:.|:....|.|.::::
Human   107 G--RYPQENKGT---YIPVPIVSEL-QSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVW 165

  Fly   176 ------------DIDTKLLGDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIW 228
                        :.||                |:||||||.||.|||::..:|:|||::|..:|:
Human   166 TPYGVLRTSRNPETDT----------------YILFNPWCEDDAVYLDNEKEREEYVLNDIGVIF 214

  Fly   229 RGSYNRLRPSVWKIGQFERHVLECSLKVLGTVGRIPPAYRGDPVRVARALSALVNSVDDDGVLLG 293
            .|..|.::...|..||||..:|:..|.|:.. .::..:.||:|::|:|..||:||:.||:|||:|
Human   215 YGEVNDIKTRSWSYGQFEDGILDTCLYVMDR-AQMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVG 278

  Fly   294 NWSEDFSGGVAPTKWTGSVEILQQFYKTQKSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAH 358
            :|...::.||.|:.|||||:||.::..::..|::.|||.|:||..|..|.||||:||:|.|.|||
Human   279 SWDNIYAYGVPPSAWTGSVDILLEYRSSENPVRYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAH 343

  Fly   359 DTQASLTVDVFI--DAN-NKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQ 420
            |..|:|.:|:|:  |.| |.||   |.||:||||.|||.||.||||.||    |.|||.||:|||
Human   344 DNDANLQMDIFLEEDGNVNSKL---TKDSVWNYHCWNEAWMTRPDLPVG----FGGWQAVDSTPQ 401

  Fly   421 EASDNMYRVGPASVAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRK-DTLAIGHL 484
            |.||.|||.|||||.|:|:|.:...||..|||||||:|.:|  .........::.. |...||.|
Human   402 ENSDGMYRCGPASVQAIKHGHVCFQFDAPFVFAEVNSDLIY--ITAKKDGTHVVENVDATHIGKL 464

  Fly   485 ISTKAVLKWEREDITDTYKHAERSEEERSTMLKALKQ-SRHAFSRYYLNDNFNDIEFDMELKDDI 548
            |.||.:......|||||||..|..||||..:..||.. ::...:...:..:.::::.|.|:::.:
Human   465 IVTKQIGGDGMMDITDTYKFQEGQEEERLALETALMYGAKKPLNTEGVMKSRSNVDMDFEVENAV 529

  Fly   549 KIGQSFSVVLKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVRMEVIF 613
             :|:.|.:.:...|.|.:| :..|..:|.:...||||...|.|...|::.|||.|  :.:..|:.
Human   530 -LGKDFKLSITFRNNSHNR-YTITAYLSANITFYTGVPKAEFKKETFDVTLEPLS--FKKEAVLI 590

  Fly   614 E--EYYDKLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQKELDVILRLE 676
            :  ||..:|..||:......|::.:|......|....:..|:|..::....:|. .::.|.:...
Human   591 QAGEYMGQLLEQASLHFFVTARINETRDVLAKQKSTVLTIPEIIIKVRGTQVVG-SDMTVTVEFT 654

  Fly   677 NPLPIPLHKGVFTVEGPGIEQPLKFKIAEIPVGGTAAATFKYTPPYAGRGTMLAKFTSKELDDVD 741
            |||...|......::|||:.:|:|....||....|........|..:|...::|..:|..|..|.
Human   655 NPLKETLRNVWVHLDGPGVTRPMKKMFREIRPNSTVQWEEVCRPWVSGHRKLIASMSSDSLRHVY 719

  Fly   742 GYRHYEIEPRP 752
            |....:|:.||
Human   720 GELDVQIQRRP 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	58..180	CDD:459971	33/141 (23%)
		TGc	324..419	CDD:214673	54/97 (56%)
		Transglut_C	538..644	CDD:460002	28/107 (26%)
		Transglut_C	652..750	CDD:460002	24/97 (25%)
F13A1	NP_000120.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27
		Transglut_N	49..164	CDD:459971	32/124 (26%)
		TGc	309..400	CDD:214673	54/97 (56%)
		Transglut_C	519..623	CDD:460002	28/107 (26%)
		Transglut_C	631..728	CDD:460002	24/97 (25%)