Protein Alignment Tg and EPB42

DIOPT Version :10

• Sequence 1: NP_609174.1
• Gene: Tg / 34093
• FlyBaseID: FBgn0031975
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_000110.2
• Gene: EPB42 / 2038
• HGNCID: 3381
• Length: 721
• Species: Homo sapiens
• Alignment Length: 718
• Identity: 193/718 - (26%)
• Similarity: 319/718 - (44%)
• Gaps: 57/718 - (7%)

  Fly    48 GASSAVLGVLKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFN---RDYSPSKDAI 109
            |:....||:...|.....|:|||||.    |.:...|.||||:||.:.::|.   |.:.|:...:
Human    29 GSGMDALGIKSCDFQAARNNEEHHTK----ALSSRRLFVRRGQPFTIILYFRAPVRAFLPALKKV 89

  Fly   110 SFIFTVADDTKPSPGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWK 174
            :  .|.....:||..:.| .|..|   |..|||...|.|.:|..:.|:.|:.:..|:...:..:.
Human    90 A--LTAQTGEQPSKINRT-QATFP---ISSLGDRKWWSAVVEERDAQSWTISVTTPADAVIGHYS 148

  Fly   175 LDIDTKLLGDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSV 239
            |     ||....|...|.....:|||||..:|.|:|::..||.||:::...||:.|:.:.::...
Human   149 L-----LLQVSGRKQLLLGQFTLLFNPWNREDAVFLKNEAQRMEYLLNQNGLIYLGTADCIQAES 208

  Fly   240 WKIGQFERHVLECSLKVLGTVGRIPPAYRGDPVRVARALSALVNSVDDDGVLLGNWSEDFSGGVA 304
            |..||||..|::.||::|....::..  ...||.|||.|.||::.:.:..||....::....|..
Human   209 WDFGQFEGDVIDLSLRLLSKDKQVEK--WSQPVHVARVLGALLHFLKEQRVLPTPQTQATQEGAL 271

  Fly   305 PTKWTGSVEILQQFYKTQ-KSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTVDV 368
            ..|..|||.||:|:...: :.|...|.|..:.|..|:.|.||||:|::|.::||..|...|.:|.
Human   272 LNKRRGSVPILRQWLTGRGRPVYDGQAWVLAAVACTVLRCLGIPARVVTTFASAQGTGGRLLIDE 336

  Fly   369 FIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVGPAS 433
            :.:....:........||.:....|.||.||.|..|    :||||::..:.......:.......
Human   337 YYNEEGLQNGEGQRGRIWIFQTSTECWMTRPALPQG----YDGWQILHPSAPNGGGVLGSCDLVP 397

  Fly   434 VAAVKNGDI-LRPFDGGFVFAEVNADKLYWR--YNGPSQPLKLLRKDTLAIGHLISTKAVLKWER 495
            |.|||.|.: |.|.... :||.:||..:.|:  .:|   .|:|...:|..:|:.||||.|.....
Human   398 VRAVKEGTLGLTPAVSD-LFAAINASCVVWKCCEDG---TLELTDSNTKYVGNNISTKGVGSDRC 458

  Fly   496 EDITDTYKHAERSEEERSTMLKALKQ-------------SRHAFSRYYLNDNFNDIEFDMELKDD 547
            ||||..||:.|.|.:|:..:.:..|:             |....|..||   .......:.|:.|
Human   459 EDITQNYKYPEGSLQEKEVLERVEKEKMEREKDNGIRPPSLETASPLYL---LLKAPSSLPLRGD 520

  Fly   548 IKIGQSFSVVLKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVRMEVI 612
            .:|    ||.|...::.|....:|.|   ..||.|.||.|.::......|.|.......:.:.:.
Human   521 AQI----SVTLVNHSEQEKAVQLAIG---VQAVHYNGVLAAKLWRKKLHLTLSANLEKIITIGLF 578

  Fly   613 FEEYYDKLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQKELDVILRLEN 677
            |..:..........:::|.|...:::...:||:|..:.:|.:..::.|.|...| .|...:.|:|
Human   579 FSNFERNPPENTFLRLTAMATHSESNLSCFAQEDIAICRPHLAIKMPEKAEQYQ-PLTASVSLQN 642

  Fly   678 PLPIPLHKGVFTVEGPG-IEQPLKFKIAEIPVGGTAAATFKYTPPYAGRGTMLAKFTSKELDDVD 741
            .|..|:...|.::.|.| |.:...::...:....|..|.|::||.:.|...:..:.......::.
Human   643 SLDAPMEDCVISILGRGLIHRERSYRFRSVWPENTMCAKFQFTPTHVGLQRLTVEVDCNMFQNLT 707

  Fly   742 GYR 744
            .|:
Human   708 NYK 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	58..180	CDD:459971	35/124 (28%)
		TGc	324..419	CDD:214673	30/94 (32%)
		Transglut_C	538..644	CDD:460002	20/105 (19%)
		Transglut_C	652..750	CDD:460002	20/94 (21%)
EPB42	NP_000110.2	Transglut_N	38..154	CDD:459971	37/130 (28%)
		TGc	291..382	CDD:214673	30/94 (32%)
		Transglut_C	505..610	CDD:460002	22/114 (19%)
		Transglut_C	618..716	CDD:460002	20/94 (21%)