DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and EPB42

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_000110.2	Gene:	EPB42 / 2038	HGNCID:	3381	Length:	721	Species:	Homo sapiens

Alignment Length:	718	Identity:	193/718 - (26%)
Similarity:	319/718 - (44%)	Gaps:	57/718 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 GASSAVLGVLKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFN---RDYSPSKDAI 109
            |:....||:...|.....|:|||||.    |.:...|.||||:||.:.::|.   |.:.|:...:
Human    29 GSGMDALGIKSCDFQAARNNEEHHTK----ALSSRRLFVRRGQPFTIILYFRAPVRAFLPALKKV 89

  Fly   110 SFIFTVADDTKPSPGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWK 174
            :  .|.....:||..:.| .|..|   |..|||...|.|.:|..:.|:.|:.:..|:...:..:.
Human    90 A--LTAQTGEQPSKINRT-QATFP---ISSLGDRKWWSAVVEERDAQSWTISVTTPADAVIGHYS 148

  Fly   175 LDIDTKLLGDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSV 239
            |     ||....|...|.....:|||||..:|.|:|::..||.||:::...||:.|:.:.::...
Human   149 L-----LLQVSGRKQLLLGQFTLLFNPWNREDAVFLKNEAQRMEYLLNQNGLIYLGTADCIQAES 208

  Fly   240 WKIGQFERHVLECSLKVLGTVGRIPPAYRGDPVRVARALSALVNSVDDDGVLLGNWSEDFSGGVA 304
            |..||||..|::.||::|....::..  ...||.|||.|.||::.:.:..||....::....|..
Human   209 WDFGQFEGDVIDLSLRLLSKDKQVEK--WSQPVHVARVLGALLHFLKEQRVLPTPQTQATQEGAL 271

  Fly   305 PTKWTGSVEILQQFYKTQ-KSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTVDV 368
            ..|..|||.||:|:...: :.|...|.|..:.|..|:.|.||||:|::|.::||..|...|.:|.
Human   272 LNKRRGSVPILRQWLTGRGRPVYDGQAWVLAAVACTVLRCLGIPARVVTTFASAQGTGGRLLIDE 336

  Fly   369 FIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVGPAS 433
            :.:....:........||.:....|.||.||.|..|    :||||::..:.......:.......
Human   337 YYNEEGLQNGEGQRGRIWIFQTSTECWMTRPALPQG----YDGWQILHPSAPNGGGVLGSCDLVP 397

  Fly   434 VAAVKNGDI-LRPFDGGFVFAEVNADKLYWR--YNGPSQPLKLLRKDTLAIGHLISTKAVLKWER 495
            |.|||.|.: |.|.... :||.:||..:.|:  .:|   .|:|...:|..:|:.||||.|.....
Human   398 VRAVKEGTLGLTPAVSD-LFAAINASCVVWKCCEDG---TLELTDSNTKYVGNNISTKGVGSDRC 458

  Fly   496 EDITDTYKHAERSEEERSTMLKALKQ-------------SRHAFSRYYLNDNFNDIEFDMELKDD 547
            ||||..||:.|.|.:|:..:.:..|:             |....|..||   .......:.|:.|
Human   459 EDITQNYKYPEGSLQEKEVLERVEKEKMEREKDNGIRPPSLETASPLYL---LLKAPSSLPLRGD 520

  Fly   548 IKIGQSFSVVLKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVRMEVI 612
            .:|    ||.|...::.|....:|.|   ..||.|.||.|.::......|.|.......:.:.:.
Human   521 AQI----SVTLVNHSEQEKAVQLAIG---VQAVHYNGVLAAKLWRKKLHLTLSANLEKIITIGLF 578

  Fly   613 FEEYYDKLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQKELDVILRLEN 677
            |..:..........:::|.|...:::...:||:|..:.:|.:..::.|.|...| .|...:.|:|
Human   579 FSNFERNPPENTFLRLTAMATHSESNLSCFAQEDIAICRPHLAIKMPEKAEQYQ-PLTASVSLQN 642

  Fly   678 PLPIPLHKGVFTVEGPG-IEQPLKFKIAEIPVGGTAAATFKYTPPYAGRGTMLAKFTSKELDDVD 741
            .|..|:...|.::.|.| |.:...::...:....|..|.|::||.:.|...:..:.......::.
Human   643 SLDAPMEDCVISILGRGLIHRERSYRFRSVWPENTMCAKFQFTPTHVGLQRLTVEVDCNMFQNLT 707

  Fly   742 GYR 744
            .|:
Human   708 NYK 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	35/125 (28%)
		TGc	324..419	CDD:214673	30/94 (32%)
		Transglut_C	538..644	CDD:279295	20/105 (19%)
		Transglut_C	652..750	CDD:279295	20/94 (21%)
EPB42	NP_000110.2	Transglut_N	37..153	CDD:279240	37/130 (28%)
		TGc	291..382	CDD:214673	30/94 (32%)
		Transglut_C	505..610	CDD:279295	22/114 (19%)
		Transglut_C	618..716	CDD:279295	20/94 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160501
Domainoid	1	1.000	61	1.000	Domainoid score	I10456
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950