DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and Epb42

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_038541.1	Gene:	Epb42 / 13828	MGIID:	95402	Length:	691	Species:	Mus musculus

Alignment Length:	713	Identity:	194/713 - (27%)
Similarity:	324/713 - (45%)	Gaps:	59/713 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LGVLKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFTVA-- 116
            |.:...|....:|:|||:|.    |.:.:.|.:|||:.|.:.::|.   :|:...:|.:..||
Mouse     5 LSIKSCDFHAAENNEEHYTK----AISSQHLTLRRGQSFTITLNFR---APTHTFLSALKKVALI 62

  Fly   117 --DDTKPSPGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWKLDIDT 179
              ...:||..:.| .|:.|   |..|||...|.|.:|..:.|..||.:..|....:..:.|.:..
Mouse    63 AQTGEQPSKINKT-QAIFP---ISSLGDQKGWSAAVEERDAQHWTVSVTTPVDAVIGHYSLLLQV 123

  Fly   180 KLLGDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVWKIGQ 244
                .|.:.|||. ...:|||||..||.|:|::..:|.|||::....|:.|:.:.::...|..||
Mouse   124 ----SGKKQYPLG-QFTLLFNPWNRDDAVFLQNEAERTEYVLNQNGFIYLGTADCIQEEPWDFGQ 183

  Fly   245 FERHVLECSLKVLGTVGRIPPAYRGDPVRVARALSALVNSVDDDGVLLGNWSEDFSGGVAPTKWT 309
            ||:.|::.|||:|....::..  ...|..|||.:.||::::....||..:.::....|....|..
Mouse   184 FEKDVMDLSLKLLSMDKQVKD--WNQPAHVARVVGALLHALKKKSVLPISQTQAAQEGALLYKRR 246

  Fly   310 GSVEILQQFYKTQ-KSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTVDVFIDAN 373
            |||.||:|:...| ::|...|.|..:.|..|:.|.||||:|::|.:.||..|..||.||.:.:..
Mouse   247 GSVPILRQWLTGQGRAVYETQAWVSAAVACTVLRCLGIPARVVTTFDSAQGTVGSLLVDEYYNEE 311

  Fly   374 NKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVGPASVAAVK 438
            ..:........||.:....|.||.||||..|    :.|||::.......:..:.......|.|||
Mouse   312 GLQNGEGQRGHIWVFQTSVECWMNRPDLSQG----YGGWQILHPRAPNGAGVLGSCSLVPVRAVK 372

  Fly   439 NGDILRPFDGGFVFAEVNADKLYWR--YNGPSQPLKLLRKDTLAIGHLISTKAVLKWEREDITDT 501
            .|::........:||.|||..:.|:  .:|..:.....|||   :|:.||||.|.....||||..
Mouse   373 EGELQLDPAVPELFAAVNASCVVWKCCEDGKLELTNSNRKD---VGNCISTKVVGSDRCEDITQN 434

  Fly   502 YKHAERSEEERSTMLKALKQSRHAFSRYYL-NDN---------FNDIEFDMELKDDIKI---GQS 553
            ||:...|.:|:..:.|..|:      |..| .||         ::.:....|....|.:   ||
Mouse   435 YKYPAGSLQEKEVLEKVQKE------RLKLGKDNGMCPPSCEPWDPLHMFFEASSSIPLSGDGQ- 492

  Fly   554 FSVVLKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVRMEVIFEEYYD 618
            .||.|......|.:.|:..|   ..|:.|.||.|..:.:......|:|.....:...:.|..:..
Mouse   493 LSVTLINPTDEEKKVHLVIG---AQALYYNGVLAAGLWSKKQLFMLKPNQVMRLSTNLSFSCFEQ 554

  Fly   619 KLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQ-KELDVILRLENPLPIP 682
            .....:..:::|.|:...|....:||::..:.|||:..::.:.|  || :.|.|.:|:.|.|..|
Mouse   555 TPPENSFLRVTAMARYSHTSLSCFAQENMAIGKPDLIIEMPKRA--AQYRPLTVSVRMHNSLEAP 617

  Fly   683 LHKGVFTVEGPG-IEQPLKFKIAEIPVGGTAAATFKYTPPYAGRGTMLAKFTSKELDDVDGYR 744
            :...:.::.|.| |.:..::.:..:..|.:....|::||.:.|...:..:.......::.|||
Mouse   618 MQNCIISIFGRGLIHREKRYGLGSLWPGSSLHTQFQFTPTHLGLQRLTVEVDCDMFQNLTGYR 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	34/126 (27%)
		TGc	324..419	CDD:214673	32/94 (34%)
		Transglut_C	538..644	CDD:279295	21/108 (19%)
		Transglut_C	652..750	CDD:279295	22/95 (23%)
Epb42	NP_038541.1	Transglut_N	6..123	CDD:279240	34/127 (27%)
		Band 3 binding. /evidence=ECO:0000250	31..39		4/7 (57%)
		TGc	261..351	CDD:214673	32/93 (34%)
		Transglut_C	475..573	CDD:279295	20/101 (20%)
		Transglut_C	588..686	CDD:279295	22/95 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850846
Domainoid	1	1.000	50	1.000	Domainoid score	I11569
eggNOG	1	0.900	-	-		E1_2CD5G
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850