DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and TGM7

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_016877392.1	Gene:	TGM7 / 116179	HGNCID:	30790	Length:	711	Species:	Homo sapiens

Alignment Length:	737	Identity:	240/737 - (32%)
Similarity:	365/737 - (49%)	Gaps:	85/737 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 AVLGVLKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFTVA 116
            |.|.:..|||....|::||||...    ..:.|.||||:||.|::.|:|.:....|.|:|:
Human     6 ATLRLESVDLQSSRNNKEHHTQEM----GVKRLTVRRGQPFYLRLSFSRPFQSQNDHITFV---- 62

  Fly   117 DDTKPSPGH--GT-----LNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWK 174
            .:|.|.|..  ||     |..:.|       |:.  |.|...:.:..:|.|.:..|:...:..:.
Human    63 AETGPKPSELLGTRATFFLTRVQP-------GNV--WSASDFTIDSNSLQVSLFTPANAVIGHYT 118

  Fly   175 LDIDTKLLGDG-SRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPS 238
            |.|:.. .|.| |.:|||...| :|||||.|:|.|||......:||:|.|...:::|....:...
Human   119 LKIEIS-QGQGHSVTYPLGTFI-LLFNPWSPEDDVYLPSEILLQEYIMRDYGFVYKGHERFITSW 181

  Fly   239 VWKIGQFERHVLECSLKVLG-TVGRIP-PA----YRGDPVRVARALSALVNSVDDDGVLLGNWSE 297
            .|..||||..:::...::|. ::..:. ||    .|.|.|.|.|.:||::||.||:|||.|||.|
Human   182 PWNYGQFEEDIIDICFEILNKSLYHLKNPAKDCSQRNDVVYVCRVVSAMINSNDDNGVLQGNWGE 246

  Fly   298 DFSGGVAPTKWTGSVEILQQF-YKTQKSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQ 361
            |:|.||:|.:|.|||.||||: .:..:.||:.|||.|:.|:.|:.|.||:|:|:::.:.|||:..
Human   247 DYSKGVSPLEWKGSVAILQQWSARGGQPVKYGQCWVFASVMCTVMRCLGVPTRVVSNFRSAHNVD 311

  Fly   362 ASLTVDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNM 426
            .:||:|.:.|.|.:.|..:..|.|||:|||||.||.|.||..|    ::||||:|.|||:.|..:
Human   312 RNLTIDTYYDRNAEMLSTQKRDKIWNFHVWNECWMIRKDLPPG----YNGWQVLDPTPQQTSSGL 372

  Fly   427 YRVGPASVAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAIGHLISTKAVL 491
            :..|||||.|::.||:...:|..||:||||||::.|.. |..|..::|..:|.:||..||||.|.
Human   373 FCCGPASVKAIREGDVHLAYDTPFVYAEVNADEVIWLL-GDGQAQEILAHNTSSIGKEISTKMVG 436

  Fly   492 KWEREDITDTYKHAERSEEERSTMLKALKQSRHAFSRYYLNDNFNDI-----------EFDMELK 545
            ..:|:.||.:||:.|.|.|||:..:||   ||........:..|.|:           :..:.|.
Human   437 SDQRQSITSSYKYPEGSPEERAVFMKA---SRKMLGPQRASLPFLDLLESGGLRDQPAQLQLHLA 498

  Fly   546 DDIKIGQSFSVVLKVSNKSESRTHMATGQIS-----CDAVLYTGVGAVEVKTLGFELELEPKSSD 605
            ...:.||...::|::....:| || ..|.|.     |...|..|.|.           .:|....
Human   499 RIPEWGQDLQLLLRIQRVPDS-TH-PRGPIGLVVRFCAQALLHGGGT-----------QKPFWRH 550

  Fly   606 YVRMEVIF------------EEYYDKLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQL 658
            .|||.:.|            ..|.:||:.:...::|..|:|::|........|..:..|.:..::
Human   551 TVRMNLDFGKETQWPLLLPYSNYRNKLTDEKLIRVSGIAEVEETGRSMLVLKDICLEPPHLSIEV 615

  Fly   659 GEAAIVAQKELDVILRLENPLPIPLHKGVFTVEGPG-IEQPLKFKIAEIPVGGTAAATFKYTPPY 722
            .|.|.|. |.|.|.:.|.|.|.:.|......:||.| |...:...:..:..|.|........|..
Human   616 SERAEVG-KALRVHVTLTNTLMVALSSCTMVLEGSGLINGQIAKDLGTLVAGHTLQIQLDLYPTK 679

  Fly   723 AGRGTMLAKFTSKELDDVDGYR 744
            ||...:....:|.|:.::.||:
Human   680 AGPRQLQVLISSNEVKEIKGYK 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	36/129 (28%)
		TGc	324..419	CDD:214673	42/94 (45%)
		Transglut_C	538..644	CDD:279295	25/133 (19%)
		Transglut_C	652..750	CDD:279295	24/94 (26%)
TGM7	XP_016877392.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10456
eggNOG	1	0.900	-	-		E1_2CD5G
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920