DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and tgm3l.4

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_031750708.1	Gene:	tgm3l.4 / 101730677	XenbaseID:	XB-GENE-6044377	Length:	814	Species:	Xenopus tropicalis

Alignment Length:	820	Identity:	230/820 - (28%)
Similarity:	355/820 - (43%)	Gaps:	214/820 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 EDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFTVADDTKPSPGHGTL 128
            |.|.:.|||..:.:    ..|::|||:.|.:.:.|:|   |.::..|.:||...        |.|
Frog     3 ESNRKGHHTEMYNS----PELILRRGQSFWITLDFDR---PIQEWESIVFTAQT--------GPL 52

  Fly   129 NALVPHDGIDY-LGDTL---EWGAGIESHEGQTLTVLIKPPSTCPVTEWKLDIDTKLLGDGSRSY 189
            ||...:..::: |.::.   .|.|.:||..|.:|.:::..|:...:..:.|.:...::|:.| :|
Frog    53 NAKFYNINVEFPLSNSWSSGRWSAVLESAPGNSLRIIMSSPANAVIGRYNLTVQICIMGNTS-TY 116

  Fly   190 PLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVWKIGQFERHVLECSL 254
            .|. ...:||||||.||:||:.:.|:|.||:::|..:|:.||...:....|..||||.::|...|
Frog   117 SLG-KFILLFNPWCLDDEVYMANEDERNEYILNDNGIIFIGSDKHIASLAWNFGQFESNILNICL 180

  Fly   255 KVL--GTVGRIPPA----YRGDPVRVARALSALVNSVDDDGVLLGNWSEDFSGGVAPTKWTGSVE 313
            .:|  ....|..||    .|..|:.|.|.:||::||.||.|||.|.|.::||.||.|..||||||
Frog   181 DMLDRSLNYRNDPAADCSKRNSPMYVGRVISAMINSNDDYGVLEGKWEKEFSDGVDPNSWTGSVE 245

  Fly   314 ILQQFYK-TQKSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTVDVFIDANNKKL 377
            ||.::.| ..:.||:.|||.|:.|:.|..|.||||:|:||.::|||:|..:|.||:..|.:.|.:
Frog   246 ILLKWQKEAYQPVKYGQCWVFAAVMCTALRCLGIPTRVITNFNSAHNTDGNLCVDLHYDNDGKFM 310

  Fly   378 DAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVGPASVAAVKNGDI 442
            :. :.|||||:|||:|.|..|.|||    ..:.||||:|:||||.|.|:||.||.||.|||.||:
Frog   311 EI-SDDSIWNFHVWDESWFLRKDLG----QFYGGWQVLDSTPQEQSQNVYRCGPTSVNAVKEGDV 370

  Fly   443 LRPFDGGFVFAEVNADKLYW--RYNGPSQPLKLLRKDTLAIGHLISTKAVLKWEREDITDTYKHA 505
            ..|:|..||::|||||::.|  ..:|..:.   ...||.|:|..||||||...||.|||..||:.
Frog   371 HLPYDTPFVYSEVNADRVTWVCHKDGRKEQ---AHSDTKAVGQFISTKAVGSNERVDITHCYKYP 432

  Fly   506 ERSEEERSTMLKA---------------------------------------------------- 518
            |.|.:||....||
Frog   433 EGSPKEREVFDKANRKLSNYRPPTDKPNDVNNTRDRRATNEVLMDNAENSRPRSNTLPSRPTANT 497

  Fly   519 LKQSR---------------------------------------HAFSRYYLNDNFN-------- 536
            |:.||                                       :.||.......:|
Frog   498 LRPSRPTPNVPLSRPMSNSVASIPSAVDWPSRPRTNTMYSRGIANGFSSRSTERLYNPRTPPLNT 562

  Fly   537 ----------------------------------------DIEFDMELKDDIKIGQSFSVVLKVS 561
                                                    ||....:|...:.:|...:::|.:.
Frog   563 FPERPPPLNTFPERPPPLNTFPERPPPLNAFPERPSLDGPDIAGKFKLLGPLAVGDDINLLLSLR 627

  Fly   562 NKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVRMEVIFEEYYDKLSSQAAF 626
            |.:.....:.. .:|...:||||....::......|.:.|....::.:::.:..|.:.|:.....
Frog   628 NLTPYHRQVIV-NLSASCILYTGRRINDIFQDQKSLIINPSQEGHISLQIPYSLYGNFLTDGNMI 691

  Fly   627 QISAAAKVKDTDYDYYAQDDFRVR----------KPDIKFQLGEAAIVAQKELDVILRLENPLPI 681
            |:.|..::           .||.:          .|.|..:..|.|::.:|.: |.:|..|||..
Frog   692 QMVAVCEL-----------PFRKKVVITKELVLDNPPISIKPLEMAVLNRKMI-VEVRFTNPLSF 744

  Fly   682 PLHKGVFTVEGPGI--------------EQPLKFKIAEIP 707
            .:......|||.|:              :|.:|||:...|
Frog   745 VVKDCTVAVEGAGLIDRQLTAVVPYIKPKQNIKFKVELTP 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	29/118 (25%)
		TGc	324..419	CDD:214673	44/94 (47%)
		Transglut_C	538..644	CDD:279295	16/105 (15%)
		Transglut_C	652..750	CDD:279295	19/70 (27%)
tgm3l.4	XP_031750708.1	Transglut_N	1..107	CDD:395697	29/118 (25%)
		TGc	256..347	CDD:214673	44/95 (46%)
		PHA03247	<482..617	CDD:223021	9/134 (7%)
		Transglut_C	604..>682	CDD:395741	12/78 (15%)
		Transglut_C	716..805	CDD:395741	19/70 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5178
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020