DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and tgm1l5

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_009295379.1	Gene:	tgm1l5 / 100535918	ZFINID:	ZDB-GENE-120718-2	Length:	699	Species:	Danio rerio

Alignment Length:	717	Identity:	261/717 - (36%)
Similarity:	382/717 - (53%)	Gaps:	46/717 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 AVLGVLKVDLCLE---DNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIF 113
            |||.|..|||...   .|.:||||..|::    ..|::|||:.|::.|..:|...|:||.:....
Zfish    12 AVLQVRSVDLIKTRKGQNRQEHHTDAFFS----NHLIIRRGQCFQMTIELSRPLIPNKDQLYLEL 72

  Fly   114 TVADDTKPSPGHGTLNALVPHDGIDYLGDTLE--WGAGIESHEGQTLTVLIKPPSTCPVTEWKLD 176
            .:.:..   |.|......||     .:.:..:  |.|.|......|:.:.:....|..:.::||.
Zfish    73 RLGNVV---PAHRDSFVSVP-----IVSEFKKNAWEAKIIEQAKTTIKLSVYSLPTACIGQYKLT 129

  Fly   177 IDTKL-LGDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVW 240
            :.|.. .|..:..|.....||:||||||.||.|||:|..:|.|||::|...::.|:..::....|
Zfish   130 VVTNCPAGKATSPYTPDNDIYMLFNPWCKDDPVYLKDEAERNEYVLNDMGKMYYGTEQQIGTRTW 194

  Fly   241 KIGQFERHVLECSLKVLGTVGRIPPAYRGDPVRVARALSALVNSVDDDGVLLGNWSEDFSGGVAP 305
            ..|||:..|||....||...|. |.:..|||:.|.|.:||||||.||.|||:|||...:.||::|
Zfish   195 NFGQFDEGVLEACFFVLEKSGS-PCSGWGDPINVVRVISALVNSNDDQGVLIGNWQNSYEGGLSP 258

  Fly   306 TKWTGSVEILQQFYKTQKS-VKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTVDVF 369
            |.|:||..||:|::|:..: |||.|||.|:||..|:.|..|:|:|.::.:||||||..|||.||:
Zfish   259 TAWSGSSAILKQYHKSGGTPVKFGQCWVFAGVTNTMLRCFGVPTRPVSNFSSAHDTDVSLTTDVY 323

  Fly   370 IDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVGPASV 434
            :|...:::.....|||||:|||||.||.||||..|    |.|||||||||||.|..::|.||.||
Zfish   324 LDEKLEEIKDLNRDSIWNFHVWNESWMTRPDLPAG----FGGWQVVDATPQETSQGVFRCGPTSV 384

  Fly   435 AAVKNGDILRPFDGGFVFAEVNADKLYW--RYNGPSQPLKLLRKDTLAIGHLISTKAVLKWERED 497
            |||::|.:...:|..|||||||:||::|  :.||....:|:   |..|:||.||||||...:|.|
Zfish   385 AAVRSGQVYLKYDTPFVFAEVNSDKVFWQRQSNGSFTVIKV---DENAVGHCISTKAVGSDQRVD 446

  Fly   498 ITDTYKHAERSEEERSTMLKAL----KQSRHAFSRYYL--NDNFNDIEFDMELKDD-IKIGQSFS 555
            ||..|||.|.|.||||.:..|.    |:|      .||  :.:..|:..|:.::|. ..:||...
Zfish   447 ITHLYKHPEGSSEERSAVEAACSFGSKRS------IYLPRSSSNTDVTVDVVMEDSGACLGQDAV 505

  Fly   556 VVLKVSNKSES-RTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVRMEVIFEEYYDK 619
            :.:.:.|:|.| ||  ...|...:||.||......::......:|:|.....:...:.:|||.::
Zfish   506 LFIVLKNRSSSART--VDLQSRVEAVDYTEHHKAFLRKDQTRAQLKPHEIQSLEWILQYEEYKEE 568

  Fly   620 LSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQKELDVILRLENPLPIPLH 684
            |..|.:..:|.:.::.:|.........||:|.||:.......|:|.| ||.|.|:.:|||...|.
Zfish   569 LEGQTSLLLSLSGRITETKQTLVKHFTFRLRTPDLVLTPVGDAVVGQ-ELKVKLKFQNPLVSVLR 632

  Fly   685 KGVFTVEGPGIEQPLKFKIAEIPVGGTAAATFKYTPPYAGRGTMLAKFTSKELDDVDGYRHYEIE 749
            ..:|.:||.|::........:|..|.|...|..:.|..:|...:||.....:|..|.|..:..::
Zfish   633 NVIFRMEGLGLQHVKTIHYGDITGGATVRLTEIFVPKRSGPQKLLATLDCPQLTQVHGVANILVK 697

  Fly   750 PR 751
            .|
Zfish   698 HR 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	31/127 (24%)
		TGc	324..419	CDD:214673	51/95 (54%)
		Transglut_C	538..644	CDD:279295	23/107 (21%)
		Transglut_C	652..750	CDD:279295	28/97 (29%)
tgm1l5	XP_009295379.1	Transglut_N	15..132	CDD:279240	31/128 (24%)
		TGc	278..369	CDD:214673	51/94 (54%)
		YebA	<280..377	CDD:224224	55/100 (55%)
		Transglut_C	500..592	CDD:279295	21/93 (23%)
		Transglut_C	601..697	CDD:279295	28/96 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H306
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010