DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and tgm3l.7

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_031750709.1	Gene:	tgm3l.7 / 100498415	XenbaseID:	XB-GENE-22168652	Length:	703	Species:	Xenopus tropicalis

Alignment Length:	726	Identity:	232/726 - (31%)
Similarity:	370/726 - (50%)	Gaps:	63/726 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 VLK-VDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFTVADDT 119
            ||| :||..:.|...|:||.:    ..:..:||||.|.::.:.|:|... |.::::.:.    :|
Frog     5 VLKSIDLQQKSNAAAHNTSDY----VSKVPIVRRGLPMKVTLAFSRALQ-STESLALVM----ET 60

  Fly   120 KPSPGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWKLDIDTKLLGD 184
            .|||...|...:|.........||  |.|.:||....|:||.|..|....:..:|  |..::...
Frog    61 GPSPSASTNTRIVMPVSSSRRNDT--WSATLESSSAGTMTVSINIPVNASIGPYK--ITAQITSA 121

  Fly   185 GSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVWKIGQFERHV 249
            |..|........||||.|...|:.|:.:..:|||||:::|.|::.||......|.|..|.||..|
Frog   122 GRTSTNDVGRCSVLFNAWASGDEAYMSNDAERKEYVLNETGLVFYGSAGFPSSSAWDYGHFEDGV 186

  Fly   250 LECSLKVLGTVGRIPPAYR----------GDPVRVARALSALVNSVDDDGVLLGNWSEDFSGGVA 304
            ::...|:|    :..|.|:          .|||.::|.|||:|||.||.||::||||.|:|||..
Frog   187 VDICFKLL----QESPEYKADPATHISKCNDPVYISRILSAMVNSQDDRGVIVGNWSGDYSGGEN 247

  Fly   305 PTKWTGSVEILQQFYKTQKSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTVDVF 369
            |:.|:|||.:||: :.....|::.|||.::|||.|..|.||:.:|:||.:.|||||..:|.::.:
Frog   248 PSSWSGSVALLQR-WSQSGPVRYGQCWVYAGVLCTTLRCLGLAARLITNFESAHDTNNNLIIEQY 311

  Fly   370 IDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVGPASV 434
            :||..:.:.  :.||:||:|.|.|.|.:|.|||    .|:||||::||||||.|...||:||.|.
Frog   312 LDAYGRSIG--SPDSVWNFHAWVECWFRRKDLG----STYDGWQILDATPQEPSGGSYRLGPTSQ 370

  Fly   435 AAVKNGDILRPFDGGFVFAEVNADKLYW--RYNGPSQPLKLLRKDTLAIGHLISTKAVLKWERED 497
            .|||.||:..||||.||.||||||::|:  |.:|   ...:|..||..:|..||||||..:.|:|
Frog   371 KAVKLGDVNLPFDGPFVLAEVNADEIYYGRRNDG---TFSILYTDTRKVGQYISTKAVGNFSRQD 432

  Fly   498 ITDTYKHAERSEEERSTMLKA----LKQSRHAFSRYYLNDNFNDIEFD---------------ME 543
            :||.||..|.|:|||.::.||    .:..|...:...||.....:..|               .:
Frog   433 VTDQYKFPEGSKEERDSLHKAQGLTARSDRVMLASRRLNATAARVVEDKPPIQEAPKPEIIGTFK 497

  Fly   544 LKDDIKIGQSFSVVLKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVR 608
            |..::::||.|:|.|.:.|.:.|:..: ..:.:..|::|......|:.:....:.|.|.....:.
Frog   498 LSGELQVGQDFTVTLNLKNPTSSKKQV-NAKWTLTAIVYNRTPVKEILSDSQSVTLAPNEEKVIE 561

  Fly   609 MEVIFEEYYDKLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQKELDVIL 673
            :.|::.:|...|:.....:.||.. |::............::.|.::....| .:...|...:.:
Frog   562 ITVLYPQYEKALTPDNMIRASAVC-VEENGGSLLVDKVITLKNPPLQITAPE-RVTWGKSATLGI 624

  Fly   674 RLENPLPIPLHKGVFTVEGPGI-EQPLKFKIAEIPVGGTAAATFKYTPPYAGRGTMLAKFTSKEL 737
            ...||:...:...|.|::|.|| ::.||..:.::.......|..:.||...|:..::|.|:..:.
Frog   625 VFTNPISEDIKNCVVTLQGSGILKKTLKVPLPDLKANQRIRAEAEVTPYRNGKRVVIAGFSCDKF 689

  Fly   738 DDVDGYRHYEI 748
            .||.||:..::
Frog   690 SDVKGYQTVDV 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	36/123 (29%)
		TGc	324..419	CDD:214673	41/94 (44%)
		Transglut_C	538..644	CDD:279295	20/120 (17%)
		Transglut_C	652..750	CDD:279295	22/98 (22%)
tgm3l.7	XP_031750709.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7212
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920