DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and LOC100488471

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_002937793.3	Gene:	LOC100488471 / 100488471	-ID:	-	Length:	684	Species:	Xenopus tropicalis

Alignment Length:	711	Identity:	239/711 - (33%)
Similarity:	373/711 - (52%)	Gaps:	63/711 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LGVLKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFTVADD 118
            |.::.:||...:|...||||.:    ...:|::|||:.|:.||.|:.:.: |...|...|:..
Frog     3 LRIISLDLLKTENRSHHHTSTY----TNTSLILRRGQEFKFKITFSEELT-SDIPIELHFSTG-- 60

  Fly   119 TKPSPGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWKLDIDTKLLG 183
            |.|...:|:| .|:.   ::......:|.|.|....|....|.:..|:...|..:.|.|   |.|
Frog    61 TTPLLSNGSL-VLIK---VNAESTKKQWRAKICESNGNEHVVEVCSPANAIVGIYSLSI---LTG 118

  Fly   184 DGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVWKIGQFERH 248
            ..:..|... .||:|:||||.||.||:.:.|:|:|||:::|..|:||||..::...|..||||.:
Frog   119 STACFYSTD-HIYLLYNPWCEDDDVYMPNEDERQEYVINNTGYIFRGSYKNIKAKPWNFGQFEDN 182

  Fly   249 VLECSLKVLGTVGRIPPAYRGDPVRVARALSALVNSVDDDGVLLGNWSEDFSGGVAPTKWTGSVE 313
            ||:|.:.:: .:|.:.|:.|.:||.::|..||::||.||:|||.|:||.::..|.||..||||..
Frog   183 VLDCCMYLM-DIGGLKPSSRRNPVIISRKFSAMINSNDDNGVLTGDWSGNYPDGTAPVAWTGSSA 246

  Fly   314 ILQQFYKTQKSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTVDVFIDANNKKLD 378
            ||:::||.:|.|.:.|||.||||:||:.|.:|||:|.:||||:||||:.:|.||.:.:.:.:.|.
Frog   247 ILKKYYKEKKPVLYGQCWVFSGVVTTVMRCIGIPARCVTCYSAAHDTEGNLRVDAYYNESGEPLS 311

  Fly   379 AETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVGPASVAAVKNGDIL 443
            ....||:||:|||||:||:|.||..|    :|||||:||||||....:::.||.||.|:|.|.:.
Frog   312 HMNKDSVWNFHVWNEVWMKRTDLPQG----YDGWQVIDATPQERYQGIFQCGPCSVTAIKKGHVY 372

  Fly   444 RPFDGGFVFAEVNADKLYW---RYN--GPSQPLKLLRKDTLAIGHLISTKAVLKWEREDITDTYK 503
            .|::|.||||||||||..|   .||  ||.   .||:::..:||..||||.|.|..|||||..||
Frog   373 LPYEGSFVFAEVNADKTNWMVHEYNIKGPH---TLLKEERSSIGKFISTKKVNKSLREDITSQYK 434

  Fly   504 HAERSEEERSTMLKALKQSRHAFSRYYLN-DNFNDIEFDMELKDDIKI----------GQSFSVV 557
            ..|.:||||....:|..         ||| ||.:..|........||:          |...:.:
Frog   435 FDEGTEEEREAYQRACS---------YLNADNPSSCERSAPAVQGIKVKIHRGHELYPGNPLNAL 490

  Fly   558 LKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVRMEVIFEEYYD---K 619
            ::|:|.::....:.. .|||....|||.....:.:....:|::.|....:.:.:..:.|..   :
Frog   491 VEVTNITDGDKTVDV-IISCQLQTYTGRITANLTSARKTVEIKKKQVASIPVTIEADLYMKSVMQ 554

  Fly   620 LSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQKELDVILRLENPLPIPLH 684
            :..:.|.:::...::::.....:.........|.|:.::.|.....| ::......:|.|.|.|.
Frog   555 VDDELAIRVNVITEIQELRERSFKSRIIHFHYPPIEMEVPETVKTGQ-QITCRFLFDNTLNIKLE 618

  Fly   685 KGVFTVEGPGIEQPLKF---KIAEIPVGGTAAATF--KYTPPYAGRGTMLAKFTSKELDDV 740
            .....||...|     |   ::||..:....|.:|  |..|...|...::|.|.|.::..:
Frog   619 NCEMNVEALDI-----FHLQRVAEWDLNPGEALSFRIKCRPKITGEKKIVADFISTQIKGI 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	32/122 (26%)
		TGc	324..419	CDD:214673	49/94 (52%)
		Transglut_C	538..644	CDD:279295	16/118 (14%)
		Transglut_C	652..750	CDD:279295	22/94 (23%)
LOC100488471	XP_002937793.3	Transglut_N	3..115	CDD:395697	32/122 (26%)
		TGc	257..348	CDD:214673	49/94 (52%)
		Transglut_C	587..684	CDD:395741	22/94 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5178
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	1	1.000	-	-		FOG0001456
OrthoInspector	1	1.000	-	-		otm48942
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.020