Protein Alignment Tg and epb42

DIOPT Version :10

• Sequence 1: NP_609174.1
• Gene: Tg / 34093
• FlyBaseID: FBgn0031975
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: XP_002935587.3
• Gene: epb42 / 100487946
• XenbaseID: XB-GENE-22168629
• Length: 943
• Species: Xenopus tropicalis
• Alignment Length: 753
• Identity: 189/753 - (25%)
• Similarity: 330/753 - (43%)
• Gaps: 114/753 - (15%)

  Fly    54 LGVLKV--------DLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPS----K 106
            :|::.:        ||.:..|::.|||...   :.:..|.:|||:.|.:.:.|   :||:    |
 Frog     1 MGIINMHDLPFVTCDLQVSKNNKNHHTIDL---SKENHLFLRRGQEFTITLRF---HSPTRLHYK 59

  Fly   107 DAISFIFTVADDTKPSPGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVT 171
            .......|......||..:||.|:.    .|..|.|...|.|.:...:....|:.|..|::..:.
 Frog    60 QLEGITLTTKTGPNPSKKNGTKNSF----PISSLSDNKFWSAKVVDAQQGLWTLSITTPASAIIG 120

  Fly   172 EWKLDIDTK----LLGDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSY 232
            .:.|.:.:|    |..|..|       ..:||||||.||.|:|.:..||:|||:::..:|:.|:.
 Frog   121 NYTLSLKSKKPTSLSQDLGR-------FMLLFNPWCKDDPVFLHNEGQRQEYVLNEDGIIYMGTE 178

  Fly   233 NRLRPSVWKIGQFERHVLECSLKVLGTVGRIPPAY----------RGDPVRVARALSALVNSVDD 287
            :.::...|..||||..:.:..:|:|.    :.|.|          |.||:.|:|.|..:::..|:
 Frog   179 SCIQQHPWHFGQFEYEIADVCIKLLD----MNPKYQKVPKNEYLNRNDPIYVSRVLGDMISRKDE 239

  Fly   288 D---GVLLGNWSEDFSGGVAPTKWTGSVEILQQFYKTQKSVKFAQCWNFSGVLTTIARSLGIPSR 349
            :   ..::.|....:.       ...||.|||::::.:....:...|.|:.||.|:.|.||||:|
 Frog   240 EDRVAFMVENRRPSYG-------LISSVPILQKWFQNEFKTVYGHHWVFAAVLCTVLRCLGIPTR 297

  Fly   350 IITCYSSAHDTQASLTVDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQV 414
            ::|.|:||:||..:|..:::.|....::....:|||||:|||||.||:|.||.    ..::||||
 Frog   298 LVTNYNSAYDTNRTLQKEIYYDEKGARIHRARSDSIWNFHVWNECWMERRDLS----PEYNGWQV 358

  Fly   415 VDATPQ-EASDNMYRVGPASVAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGP--SQPLKLLRK 476
            :|||.| ::|:.:...|||.:.|:|.|.:...::...:|:::..|.:.|..|..  |:.|...|.
 Frog   359 LDATAQLKSSEALCVSGPAPMRAIKEGHVDLNYNVDLIFSKLVTDNMVWVRNPKCFSKVLCWARH 423

  Fly   477 DTLAIGHLISTKAVLKWEREDITDTYKHAERSEEE-------RSTMLK--ALKQSRH-AFSRYYL 531
                :|..||||:|....:||:...||:.:.|.||       ..||||  .:|.|:. :.|...:
 Frog   424 ----VGDSISTKSVGSDMQEDLVHHYKYPKGSAEETEVLRIVTQTMLKNHQVKDSKETSLSPATV 484

  Fly   532 NDNFNDIEFDMELKDDIKIGQSFSVVLKVSNKS-ESRTHMATGQISCDAVLYTGVGAVEVKTLG- 594
            :.:..:::.         .|:.....:.|:|.| |.|.....            |||..|...|
 Frog   485 SISSQNLQM---------YGEDIHFKVTVANVSWEERDFKML------------VGAQPVHDHGF 528

  Fly   595 ---------FELELEPKSSDYVRMEVIFEEYYDKLSSQAAFQISAAAK--VKDTDYDYYAQDDFR 648
                     |....:|.....:.:.:....|...|......:|:|..|  ..:.|....|:.|..
 Frog   529 TQAQFWKEEFAFHFKPYEGCNLSIHLDHSSYEACLLDNNLLRITALVKDPTCENDNVALAEQDMT 593

  Fly   649 VRKPDIKFQLGEAAIVAQKELDVILRLENPLPIPLHKGVFTVEGPG-IEQPLKFKIAEIPVGGTA 712
            :.||.:..|....::..| .:..::...||....|.:.|....|.| :....:::...:...||.
 Frog   594 ICKPCLSVQAPRVSLQYQ-PMTAMIHFTNPSEKTLLECVLRASGKGLLHSERQYRCGNVAPRGTL 657

  Fly   713 AATFKYTPPYAGRGTMLAKFTSKELDDVDGYRHYEIEP 750
            .....:||...|...:..:.......::.|:..:|:.|
 Frog   658 RYPITFTPTQVGPRRLYVQLECSIFRNIIGFHQFEVLP 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	58..180	CDD:459971	30/133 (23%)
		TGc	324..419	CDD:214673	40/94 (43%)
		Transglut_C	538..644	CDD:460002	19/118 (16%)
		Transglut_C	652..750	CDD:460002	16/98 (16%)
epb42	XP_002935587.3	Transglut_N	14..127	CDD:459971	30/122 (25%)
		TGc	271..362	CDD:214673	39/94 (41%)
		Transglut_C	597..688	CDD:460002	14/91 (15%)
		Transglut_C	726..820	CDD:460002
		Transglut_C	837..931	CDD:460002