DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tg and epb42

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_002935587.3	Gene:	epb42 / 100487946	XenbaseID:	XB-GENE-22168629	Length:	943	Species:	Xenopus tropicalis

Alignment Length:	753	Identity:	189/753 - (25%)
Similarity:	330/753 - (43%)	Gaps:	114/753 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LGVLKV--------DLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPS----K 106
            :|::.:        ||.:..|::.|||...   :.:..|.:|||:.|.:.:.|   :||:    |
Frog     1 MGIINMHDLPFVTCDLQVSKNNKNHHTIDL---SKENHLFLRRGQEFTITLRF---HSPTRLHYK 59

  Fly   107 DAISFIFTVADDTKPSPGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVT 171
            .......|......||..:||.|:.    .|..|.|...|.|.:...:....|:.|..|::..:.
Frog    60 QLEGITLTTKTGPNPSKKNGTKNSF----PISSLSDNKFWSAKVVDAQQGLWTLSITTPASAIIG 120

  Fly   172 EWKLDIDTK----LLGDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSY 232
            .:.|.:.:|    |..|..|       ..:||||||.||.|:|.:..||:|||:::..:|:.|:.
Frog   121 NYTLSLKSKKPTSLSQDLGR-------FMLLFNPWCKDDPVFLHNEGQRQEYVLNEDGIIYMGTE 178

  Fly   233 NRLRPSVWKIGQFERHVLECSLKVLGTVGRIPPAY----------RGDPVRVARALSALVNSVDD 287
            :.::...|..||||..:.:..:|:|.    :.|.|          |.||:.|:|.|..:::..|:
Frog   179 SCIQQHPWHFGQFEYEIADVCIKLLD----MNPKYQKVPKNEYLNRNDPIYVSRVLGDMISRKDE 239

  Fly   288 D---GVLLGNWSEDFSGGVAPTKWTGSVEILQQFYKTQKSVKFAQCWNFSGVLTTIARSLGIPSR 349
            :   ..::.|....:.       ...||.|||::::.:....:...|.|:.||.|:.|.||||:|
Frog   240 EDRVAFMVENRRPSYG-------LISSVPILQKWFQNEFKTVYGHHWVFAAVLCTVLRCLGIPTR 297

  Fly   350 IITCYSSAHDTQASLTVDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQV 414
            ::|.|:||:||..:|..:::.|....::....:|||||:|||||.||:|.||.    ..::||||
Frog   298 LVTNYNSAYDTNRTLQKEIYYDEKGARIHRARSDSIWNFHVWNECWMERRDLS----PEYNGWQV 358

  Fly   415 VDATPQ-EASDNMYRVGPASVAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGP--SQPLKLLRK 476
            :|||.| ::|:.:...|||.:.|:|.|.:...::...:|:::..|.:.|..|..  |:.|...|.
Frog   359 LDATAQLKSSEALCVSGPAPMRAIKEGHVDLNYNVDLIFSKLVTDNMVWVRNPKCFSKVLCWARH 423

  Fly   477 DTLAIGHLISTKAVLKWEREDITDTYKHAERSEEE-------RSTMLK--ALKQSRH-AFSRYYL 531
                :|..||||:|....:||:...||:.:.|.||       ..||||  .:|.|:. :.|...:
Frog   424 ----VGDSISTKSVGSDMQEDLVHHYKYPKGSAEETEVLRIVTQTMLKNHQVKDSKETSLSPATV 484

  Fly   532 NDNFNDIEFDMELKDDIKIGQSFSVVLKVSNKS-ESRTHMATGQISCDAVLYTGVGAVEVKTLG- 594
            :.:..:::.         .|:.....:.|:|.| |.|.....            |||..|...|
Frog   485 SISSQNLQM---------YGEDIHFKVTVANVSWEERDFKML------------VGAQPVHDHGF 528

  Fly   595 ---------FELELEPKSSDYVRMEVIFEEYYDKLSSQAAFQISAAAK--VKDTDYDYYAQDDFR 648
                     |....:|.....:.:.:....|...|......:|:|..|  ..:.|....|:.|..
Frog   529 TQAQFWKEEFAFHFKPYEGCNLSIHLDHSSYEACLLDNNLLRITALVKDPTCENDNVALAEQDMT 593

  Fly   649 VRKPDIKFQLGEAAIVAQKELDVILRLENPLPIPLHKGVFTVEGPG-IEQPLKFKIAEIPVGGTA 712
            :.||.:..|....::..| .:..::...||....|.:.|....|.| :....:::...:...||.
Frog   594 ICKPCLSVQAPRVSLQYQ-PMTAMIHFTNPSEKTLLECVLRASGKGLLHSERQYRCGNVAPRGTL 657

  Fly   713 AATFKYTPPYAGRGTMLAKFTSKELDDVDGYRHYEIEP 750
            .....:||...|...:..:.......::.|:..:|:.|
Frog   658 RYPITFTPTQVGPRRLYVQLECSIFRNIIGFHQFEVLP 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	30/134 (22%)
		TGc	324..419	CDD:214673	40/94 (43%)
		Transglut_C	538..644	CDD:279295	19/118 (16%)
		Transglut_C	652..750	CDD:279295	16/98 (16%)
epb42	XP_002935587.3	Transglut_N	14..129	CDD:395697	30/124 (24%)
		TGc	271..362	CDD:214673	39/94 (41%)
		Transglut_C	597..688	CDD:395741	14/91 (15%)
		Transglut_C	726..820	CDD:395741
		Transglut_C	837..931	CDD:395741
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010