DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and tgm1

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_002939073.2	Gene:	tgm1 / 100487465	XenbaseID:	XB-GENE-1013422	Length:	779	Species:	Xenopus tropicalis

Alignment Length:	726	Identity:	249/726 - (34%)
Similarity:	382/726 - (52%)	Gaps:	46/726 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 PQGDKTDGASS-------------AVLGVLKVDLCLE---DNHEEHHTSHFYAAAAKEALVVRRG 89
            |.|...|...|             ..|.|..|||..:   :....|||..|    ..:.|:||||
Frog    83 PDGGSRDNRPSVNPPSPSLTPSIGGPLQVQNVDLLKQRGGETRRAHHTDEF----EYDELIVRRG 143

  Fly    90 EPFRLKIHFNRDYSPSKDAISFIFTVADDTKPSPGHGTLNALVPHDGIDYLGDTLEWGAGIESHE 154
            :||::.:.|.|.::|..|.|..:..:| :.:|.    ||:.:   :..|..|    |...:....
Frog   144 QPFKICVTFQRAFNPKSDRICVVLQMA-NAQPI----TLSQV---NEFDESG----WACQVAEVN 196

  Fly   155 GQTLTVLIKPPSTCPVTEWKLDIDTKLLGDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEY 219
            |....:.:...:..|:..:::.:.|. .|:|    |..|.:|:|||.||..|.|::::...|:||
Frog   197 GCKSNIWLNTSAQAPIGLYQMIVKTN-SGEG----PSNLRVYILFNAWCRMDSVFMDNEAWRQEY 256

  Fly   220 VMHDTTLIWRGSYNRLRPSVWKIGQFERHVLECSLKVLGTVGRIPPAYRGDPVRVARALSALVNS 284
            |:::...|:.|:.|::....|..|||::.||:..|.:| ..|||.|..||||:.|.|.:||:|||
Frog   257 VLNEIGRIYYGTQNQIGERSWNYGQFDKGVLDACLYLL-DCGRIAPGSRGDPINVTRVISAMVNS 320

  Fly   285 VDDDGVLLGNWSEDFSGGVAPTKWTGSVEILQQFYKTQKSVKFAQCWNFSGVLTTIARSLGIPSR 349
            :||:||:.|:||.|::.||.|..|.|||:||.:::::..|||:.|||.|.||.||:.|.||||.|
Frog   321 MDDNGVVAGSWSGDYADGVNPVAWVGSVDILLRYHQSGSSVKYGQCWVFGGVTTTVLRCLGIPGR 385

  Fly   350 IITCYSSAHDTQASLTVDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQV 414
            .||.::||||...:||.|::.|.|.|.::.:..||:|||||||:.||.||||..|    :.|||.
Frog   386 TITNFASAHDADGNLTFDIYFDENMKPIEDKNRDSVWNYHVWNDCWMTRPDLPAG----YSGWQA 446

  Fly   415 VDATPQEASDNMYRVGPASVAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTL 479
            :|:||||.|:.:|..||..:.|:|||.....:|..|:|||||:||: .....|:...|.:..:..
Frog   447 IDSTPQETSNGIYCCGPCPLLAIKNGLTNIKYDAPFIFAEVNSDKV-CHQRMPNGQFKRVLVEER 510

  Fly   480 AIGHLISTKAVLKWEREDITDTYKHAERSEEERSTMLKALKQSRHAFSRYYLNDNFNDIEFDMEL 544
            |:||.||||||..:.|:|||..|||.|.|.|||:::..|.:.|....:... |:..:|:...:|.
Frog   511 AVGHCISTKAVGSFARDDITYLYKHPEGSTEERNSVHTAARYSNKPLAAVD-NEETSDVSMSVES 574

  Fly   545 KDDIKIGQSFSVVLKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVRM 609
            :|.:..|...:|.:.:.|.|.||..::. .::...:.|.|:.....|....:..|.|.....|.|
Frog   575 QDGVITGSDINVRVLLKNNSNSRRCVSL-SLTVGVMYYNGICKESFKNETRDTTLNPGEGKAVGM 638

  Fly   610 EVIFEEYYDKLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQKELDVILR 674
            .:.:.||...|..|.|..::.:..|.:|......|..||.|.||:..::...|||.|:.:..::
Frog   639 LISYAEYSKHLVDQGAMMLTVSGIVNETGQKLAKQHTFRTRTPDLVIKVRGDAIVGQQIVAEVI- 702

  Fly   675 LENPLPIPLHKGVFTVEGPGIEQPLKFKIAEIPVGGTAAATFKYTPPYAGRGTMLAKFTSKELDD 739
            .:|||...||..||.|||||:::|...|...|....|...:.::||...|....:|...|.||..
Frog   703 FKNPLNTTLHNAVFHVEGPGLQRPKVIKYGNIGPLQTVCVSERFTPRRPGPRQFIASLESNELSQ 767

  Fly   740 VDGYRHYEIEP 750
            |.|.....::|
Frog   768 VHGTTEVVVQP 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	29/125 (23%)
		TGc	324..419	CDD:214673	49/94 (52%)
		Transglut_C	538..644	CDD:279295	22/105 (21%)
		Transglut_C	652..750	CDD:279295	31/97 (32%)
tgm1	XP_002939073.2	PRK12678	<22..>91	CDD:237171	3/7 (43%)
		Transglut_N	109..221	CDD:395697	30/127 (24%)
		TGc	360..451	CDD:214673	49/94 (52%)
		Transglut_C	568..673	CDD:395741	22/105 (21%)
		Transglut_C	681..778	CDD:395741	31/97 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5178
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H306
Inparanoid	1	1.050	423	1.000	Inparanoid score	I1742
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	1	1.000	-	-		FOG0001456
OrthoInspector	1	1.000	-	-		otm48942
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5185
SonicParanoid	1	1.000	-	-		X1344
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.100