DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and tgm5

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_031750630.1	Gene:	tgm5 / 100486682	XenbaseID:	XB-GENE-986930	Length:	726	Species:	Xenopus tropicalis

Alignment Length:	743	Identity:	230/743 - (30%)
Similarity:	373/743 - (50%)	Gaps:	77/743 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 DLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHF-NRDYSPSKDAISFIFTVADDTKPSP 123
            |..::.|::.|||..    .....|.:|||:||.:.:|| .|.:.|.:|.:  ||.|.....|..
Frog     9 DFQIKRNNKAHHTDE----TGDRRLFIRRGQPFFITVHFKTRGFQPGQDNV--IFLVETGPWPDE 67

  Fly   124 GHGTLNALVPHDGIDYLGDTLE---WGAGIESHEGQTLTVLIKPPSTCPVTEWKLDIDTKLLGDG 185
            ..|| .|:.|      |...|.   |.|.:|::...::.:.:..|.|..:.:::|.:.   :..|
Frog    68 SSGT-KAIFP------LSKALNKTMWSATLENNGANSMVLAMLSPHTAIIGQYQLKMQ---ISSG 122

  Fly   186 SRSYPLPLPIYV-LFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVWKIGQFERHV 249
            :::....|..:| ||||||.||.|::.:..:|:|||::|...:::|::|.:.|..|..||||..:
Frog   123 TKTTNYNLGTFVLLFNPWCADDDVFMGNEAERQEYVINDYGFVYQGNHNWIIPCAWNFGQFEDDI 187

  Fly   250 LECSLKVLG-TVGRIPPAY-----RGDPVRVARALSALVNSVDDDGVLLGNWSEDFSGGVAPTKW 308
            ::.|||:|. .:..|..::     |.:||.::|.:.|::||.||:|||.||||.|::.||:|:.|
Frog   188 VDISLKILDKNLNYIQDSFKDLKNRNNPVYISRVICAMINSNDDNGVLQGNWSGDYTNGVSPSAW 252

  Fly   309 TGSVEILQQFYKTQ-KSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTVDVFIDA 372
            .||:.||:|:||:. :.||:.|||.|:.|:.|:.|.||||:|::|.:.|||||..:|.:|.:.|.
Frog   253 NGSILILRQWYKSDCQPVKYGQCWVFAAVMCTVMRCLGIPARVVTNFDSAHDTDQNLLIDEYYDT 317

  Fly   373 NNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVGPASVAAV 437
            ..|||..||.|||||:|||.|.||.|.||..|    :.||||:|.||||||:.::..|||||.|:
Frog   318 TGKKLSKETKDSIWNFHVWCECWMARRDLPPG----YGGWQVLDPTPQEASNGIFVCGPASVKAI 378

  Fly   438 KNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAIGHLISTKAVLKWEREDITDTY 502
            :.|||...:|..||||.||||.:.|..:  ::..:....|...:|..||||.....||||:|..|
Frog   379 REGDIHLNYDAPFVFAMVNADCVSWIVS--TKGKEKYHCDPHLVGTQISTKRAGSDEREDLTHQY 441

  Fly   503 KHAERSEEERSTMLKA------------LKQSRH-----------------AFSRY---YLNDNF 535
            |:.|.:.|||....||            :.:|.|                 ..|||   ..|.|.
Frog   442 KYEEETAEERKAFEKAISRLHKGGAIPNINESEHMNGANGTSANGITPSPDESSRYTPQNENSNL 506

  Fly   536 ND------IEFDMELKDDIKIGQSFSVVLKVSNK-SESRTHMATGQISCDAVLYTGVGAVEVKTL 593
            |.      :....:|.:..::|::.|:||...|. |.::|...:  :|..|:.:.|..|.:....
Frog   507 NSPLREALLLLKFKLTESPQLGETISLVLLAGNMVSTAKTLKLS--LSAQAMKHDGKPAQQFWRD 569

  Fly   594 GFELELEPKSSDYVRMEVIFEEYYDKLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQL 658
            ...:||.|....::..::.:.:|...|......:..|..:...|......:.|..:..|.:....
Frog   570 SMYVELGPHEEKWLLFKIPYAKYGPSLEDNHLIRFIAVGEQNITWEKVLVEKDVNLALPAVVINF 634

  Fly   659 GEAAIVAQKELDVILRLENPLPIPLHKGVFTVEGPG-IEQPLKFKIAEIPVGGTAAATFKYTPPY 722
            .|.|:| .|.....|...||:...:|.....::|.| :::.:|..:..:..|..|...|::.|..
Frog   635 LELAVV-DKTCKAELSFSNPINEAIHDCQILIQGSGLLKKQVKLNMGTMKPGQKAVVAFEFVPWK 698

  Fly   723 AGRGTMLAKFTSKELDDVDGYRHYEIEP 750
            .|...:....:|.....:.|::...::|
Frog   699 VGYKQLQVNISSNRFKGLKGFKSVVVKP 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	32/122 (26%)
		TGc	324..419	CDD:214673	48/94 (51%)
		Transglut_C	538..644	CDD:279295	19/106 (18%)
		Transglut_C	652..750	CDD:279295	19/98 (19%)
tgm5	XP_031750630.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5178
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020