DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and tgm3l.1

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_031750711.1	Gene:	tgm3l.1 / 100486088	XenbaseID:	XB-GENE-6258365	Length:	692	Species:	Xenopus tropicalis

Alignment Length:	712	Identity:	228/712 - (32%)
Similarity:	362/712 - (50%)	Gaps:	66/712 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 VDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSK-DAISFIFTVADDTKPS 122
            :|..|..|.:||.|......    .||||||.||.:|:.|......:| :.::.|..:.  ..||
Frog    10 IDFDLLKNVQEHRTQGIRGM----GLVVRRGWPFTMKMQFRYLGQDAKLENLNLIAQIG--PYPS 68

  Fly   123 PGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWKLDID--------T 179
            |..|| :...|   :..|.|...|.|.:|......|.|.::.|:|..:..:.|.::        :
Frog    69 PHTGT-HIYFP---VSRLRDNRSWSAEMEGENNGVLAVKVQTPATAIIGRYSLSLEGSYRGMPVS 129

  Fly   180 KLLGDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVWKIGQ 244
            .:||:          :.:|||||||:|.|:|.|...|:||||::...:::|:.:.::...|..||
Frog   130 HILGN----------VVLLFNPWCPEDDVFLNDEAMRQEYVMNEHGTMYQGTKDFIKNIPWNYGQ 184

  Fly   245 FERHVLECSLKVLGTVGRIPP----------AYRGDPVRVARALSALVNSVDDDGVLLGNWSEDF 299
            ||..|.|..|::|.    :.|          :.||||:.:.|.:||::||.||.||:..:|.:..
Frog   185 FEDGVGETCLRILD----MSPSCLKDPATDCSKRGDPIFICRVVSAMINSNDDRGVIESSWDDLV 245

  Fly   300 SGGVAPTKWTGSVEILQQFYKTQ-KSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQAS 363
            .|||.|:.|.|||.||:|::.:. :.||:.|||.|:|||.|:.|.||||:|.:|.:.|||||..:
Frog   246 RGGVEPSSWNGSVAILRQWHTSGCRPVKYGQCWVFAGVLCTVMRFLGIPTRPVTNFESAHDTNCT 310

  Fly   364 LTVDVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYR 428
            ||||.:.|...|:|:. ..|:|||:|||||.||.|.||..|    :||||:||:||||.|...|.
Frog   311 LTVDEYYDETGKQLET-LGDTIWNFHVWNECWMARKDLRSG----YDGWQIVDSTPQEISGGTYC 370

  Fly   429 VGPASVAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAIGHLISTKAVLKW 493
            .|||.|.|||.||:...:|..||:||||.|.::|..|  .:.:|..:.||:|||...:||.|...
Frog   371 CGPAPVKAVKEGDMDVSYDVPFVYAEVNGDVIHWVVN--EKGIKQGQVDTIAIGKNFTTKRVGSN 433

  Fly   494 EREDITDTYKHAERSEEERSTMLKALK--QSRHAFSRYYLNDNFNDIEFDMELKDDIKIGQSFSV 556
            ::||:|..|||||.|.:||:...||..  :|:..||... :...:|.|..::|.:...|||...:
Frog   434 DKEDVTSHYKHAEGSPQERTVFAKATSAVKSKRPFSAKE-SGMASDFEVSLKLAETPMIGQPIVL 497

  Fly   557 VLKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVRMEVIFEEYYDKLS 621
            ..::.|||.:...::. .:|..|:.|.|....:.....|::::.|..:...:..:...:|...:.
Frog   498 YCRILNKSFAAKKLSV-NMSAQAMQYNGTPLDQFWRKKFDVDVFPNQATDGQFPIHPLQYQQFIR 561

  Fly   622 SQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQL-GEAAIVAQKELDVILRLENPLPIPLHK 685
            ...:.:::..|....:....:|..:..:::|.|..:: |....  .:.|:|.|..:||....|..
Frog   562 PGNSIRVTVLATDLQSKQFRFAAQNVVLKEPTIDIKIYGTPQF--NRPLNVQLSFQNPFNEVLTN 624

  Fly   686 GVFTVEGPGIEQPLKFKIAEIPVGG-----TAAATFKYTPPYAGRGTMLAKFTSKELDDVDG 742
            .|.:.||.|:   |....|||.:|.     ..:......|...|:..:...|:..::..:.|
Frog   625 CVMSAEGAGL---LPNGPAEIYMGNIYSLRAGSVGLVCVPIKRGKLQLEVSFSCNKVQHIKG 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	34/128 (27%)
		TGc	324..419	CDD:214673	50/94 (53%)
		Transglut_C	538..644	CDD:279295	16/105 (15%)
		Transglut_C	652..750	CDD:279295	22/97 (23%)
tgm3l.1	XP_031750711.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11590
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110