DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and tgm3l.5

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_031749864.1	Gene:	tgm3l.5 / 100485935	XenbaseID:	XB-GENE-22168644	Length:	726	Species:	Xenopus tropicalis

Alignment Length:	743	Identity:	231/743 - (31%)
Similarity:	374/743 - (50%)	Gaps:	69/743 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 VLGVLKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFTVAD 117
            ||.:.|..:....|..||.|:::    :...|::||.:.||:.::|||... .||.:.  ||.|.
Frog     3 VLRLRKFSMEESSNMAEHRTNYY----SSSDLILRRAQAFRIMLYFNRPLQ-EKDKVE--FTAAT 60

  Fly   118 DTKPSPGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWKLDIDTKLL 182
            ...|.....|: .:.|..|..   ....|.|.::|.:...:|.:|...:...:..:||.:.|  .
Frog    61 GPDPQEADDTM-CIFPLFGSQ---SKASWTAEVDSIDSNCVTAIITSSADAVIGRYKLQLYT--T 119

  Fly   183 GDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVWKIGQFER 247
            ....:||.......:|||||..||.||:||.::|.|||::|..:|:.|....:....|..||||.
Frog   120 SSKKKSYFKLREFVLLFNPWAEDDVVYMEDENERCEYVLNDHGIIYIGHEEMIDEQGWDFGQFEE 184

  Fly   248 HVLECSLKVLGTVGRIPPAYRGDPV----------RVARALSALVNSVDDDGVLLGNWSEDFSGG 302
            ::|:.||::|..    ...|:.|||          .|.|.|:|::||.||||||.|.|:..|:||
Frog   185 NILDISLQILDR----SLNYQDDPVLDCSQRYDPGYVGRVLTAMINSFDDDGVLEGRWTGKFTGG 245

  Fly   303 VAPTKWTGSVEILQQFYK-TQKSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTV 366
            |.|..|.||||||.::|: ..|.||:.|||.|:.|:.|:.|.||||:|:||.::||||...:|.:
Frog   246 VDPQHWIGSVEILMRWYRGGYKPVKYGQCWVFAAVMCTVLRCLGIPTRVITNFASAHDKDGNLGI 310

  Fly   367 DVFIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVGP 431
            |....::.:.:   :.|::||:|||||.|.:|.|||    ..:.||||:||||||.|:..|..||
Frog   311 DSIYSSSGRNM---SKDTMWNFHVWNESWFRRNDLG----SAYRGWQVLDATPQELSEGTYCCGP 368

  Fly   432 ASVAAVKNGDILRPFDGGFVFAEVNADKLYWRYNGPSQPLKLLRKDTLAIGHLISTKAVLKWERE 496
            ||:.|||.||:.:.::..|||||||||:..|.|.......|:. .|:.::|..:|||:|...||.
Frog   369 ASLHAVKEGDVDKDYNVPFVFAEVNADRNTWVYYAKDVKEKVY-TDSKSVGKHMSTKSVGGNERV 432

  Fly   497 DITDTYKHAERSEEERSTMLKALKQ------------------SRHAFSRYYLNDNFNDIEFDME 543
            :||:.||:.|.:|:||...|||.|:                  .:....|...:::.:|.|...|
Frog   433 EITNNYKYPEGTEKERQVYLKARKKLLDMGVLKDENLGRRFIGKKRYKKRGRASESADDSEEPTE 497

  Fly   544 L----KDDI----KIGQSFSVVLKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELE 600
            |    |..:    |.|...:::|.:.| |..::.....::|..|:.|||....|:.:....:.|.
Frog   498 LGIIGKFQLVAPPKFGDDVNLILSLRN-SGQKSEALKVKLSSSAIKYTGRPMSEIFSDQTSVTLG 561

  Fly   601 PKSSDYVRMEVIFEEYYDKLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVA 665
            ......:.:.:...:|.::|:.....::.|..::| :......:....:.||.:..|:....:|.
Frog   562 SMKEKQIPINIAASQYEEELTKDHLIEVVALCELK-SKKKMLVRRVVSIEKPPLLIQVLSYPVVD 625

  Fly   666 QK-ELDVILRLENPLPIPLHKGVFTVEGPG-IEQPLKFKIAEIPVGGTAAATFKYTPPYAGRGTM 728
            :. ||.|  ..:|||.:||..|:..:.|.| |.:.:|.::.::......:...:.||...|...:
Frog   626 ELCELQV--SFKNPLSVPLTDGILLLGGSGLIRKQIKRRVPKLGPKAEGSIVLEITPYRFGTQQL 688

  Fly   729 LAKFTSKELDDVDGYRHYEI-EPRPEDL 755
            :..|.||....:.|::..|: |...||:
Frog   689 VVDFISKHFSAIKGFKRIEVAEDHLEDI 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	29/122 (24%)
		TGc	324..419	CDD:214673	41/94 (44%)
		Transglut_C	538..644	CDD:279295	20/113 (18%)
		Transglut_C	652..750	CDD:279295	24/100 (24%)
tgm3l.5	XP_031749864.1	Transglut_N	4..119	CDD:395697	31/127 (24%)
		TGc	268..356	CDD:214673	41/94 (44%)
		Transglut_C	500..592	CDD:395741	15/92 (16%)
		Transglut_C	612..709	CDD:395741	24/98 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010