DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and tgm1

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_009294851.1	Gene:	tgm1 / 100334173	ZFINID:	ZDB-GENE-030131-9032	Length:	734	Species:	Danio rerio

Alignment Length:	763	Identity:	279/763 - (36%)
Similarity:	417/763 - (54%)	Gaps:	52/763 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QKLSCCQKCGDW-KWC-----TSKDNEESTLRIRNANANYFTGIPQGDKTD-GASSAVLGVLKVD 60
            ||.|    ||.| :.|     .|..|..||....|..|         :||: .|:.::|.|..|:
Zfish     6 QKWS----CGAWFRQCCCSCRKSHKNTNSTPHAANTTA---------EKTETPATGSLLEVRSVN 57

  Fly    61 L---CLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFTVADDTKPS 122
            |   ..|.|..||||..:    ..|.|::|||:.|:::|..:|.:.|..|.:.....:.|  .|.
Zfish    58 LLKSSKEQNRLEHHTERY----RSENLIIRRGQTFQMQIELSRAFDPKTDKLHLDLKLGD--LPD 116

  Fly   123 PGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWKLDIDTKL-LGDGS 186
            ...|| :.:||.  ::.|.|.. |.|.|...:|:.:.:.:....|.|:.::||.:.|.. :|:..
Zfish   117 VSKGT-HVVVPL--VEELQDNC-WEAKIVEQKGRLIKLSVNSLPTAPIGKYKLGVATSCPVGESM 177

  Fly   187 RSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVWKIGQFERHVLE 251
            ..|.....||:||||||.:|.||::...:|||||::|..:|:.|:.:::....|..|||::.:|.
Zfish   178 SPYNPDNDIYMLFNPWCEEDSVYMDSEKERKEYVLNDMGIIYYGTDSQIGYRTWNFGQFDKSILP 242

  Fly   252 CSLKVLGTVGRIPPAYRGDPVRVARALSALVNSVDDDGVLLGNWSEDFSGGVAPTKWTGSVEILQ 316
            ..|.:|...| .|.:..||||.|.|.|||::|:.||:|||:||||..:..|.|||.|:||.:||:
Zfish   243 ACLFLLERSG-APASGWGDPVNVVRLLSAMINAPDDNGVLVGNWSGTYDDGTAPTFWSGSSDILR 306

  Fly   317 QFYKTQKS-VKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTVDVFIDANNKKLDAE 380
            |:|....: |::.|||.||||.|::.|.||||:|.||.:.|||||.||||.||::|.|::.::..
Zfish   307 QYYNNGGTPVRYGQCWVFSGVTTSVMRCLGIPTRSITNFESAHDTDASLTTDVYLDENHELIEEL 371

  Fly   381 TTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVGPASVAAVKNGDILRP 445
            .:||:||:||||:.||.||||..|    ..|||||||||||.|...:|.||||||||:||.:...
Zfish   372 CSDSVWNFHVWNDCWMARPDLPAG----LGGWQVVDATPQETSQGAFRCGPASVAAVRNGLVYLK 432

  Fly   446 FDGGFVFAEVNADKLYWR--YNGPSQPLKLLRKDTLAIGHLISTKAVLKWEREDITDTYKHAERS 508
            .|..|||||||:||:||:  .:|...|:::.:|   |:||.||||||...||||:|..||:.|.|
Zfish   433 HDTPFVFAEVNSDKVYWQRTADGSFTPVQIKKK---AVGHCISTKAVGSDEREDVTHLYKYPEDS 494

  Fly   509 EEERSTMLKALKQSRHAFSRYYLNDNFNDIEFDMELK-DDIKIGQSFSVVLKVSN-KSESRTHMA 571
            ||||..:..|::....|  ..|...:.||:..::.:. :|.::|...::.:.|.| .||.||...
Zfish   495 EEERIAVETAVQHGSKA--GLYEISSVNDVSIEISMDGEDPQLGSDANLAITVKNSSSEMRTFQL 557

  Fly   572 TGQISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVRMEVIFEEYYDKLSSQAAFQISAAAKVKD 636
            :.|::  ...||||....|:.....:||:|..::.|...::::.|.|.|..||...:....:|.:
Zfish   558 SAQVA--VTYYTGVYKGTVRKDQISIELKPNEAETVEWTLLYDHYKDHLVDQAMLMLILTGRVNE 620

  Fly   637 TDYDYYAQDDFRVRKPDIKFQLGEAAIVAQKELDVILRLENPLPIPLHKGVFTVEGPGIEQPLKF 701
            |......|..||:|.||:..:....|:|. |||...:...|||...|....|.:||.|::...:.
Zfish   621 TKQVLVNQFHFRLRTPDLAIKTEGDAVVG-KELKASITFRNPLKQTLKNVKFRIEGLGLQHVREI 684

  Fly   702 KIAEIPVGGTAAATFKYTPPYAGRGTMLAKFTSKELDDVDGYRHYEIE 749
            ....|....|...|..:.|..||:..:||...|::|..|.|..:..::
Zfish   685 SHGNIESLATVTLTETFIPLEAGQHKLLAALDSRQLPQVHGVANITVK 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	35/125 (28%)
		TGc	324..419	CDD:214673	52/95 (55%)
		Transglut_C	538..644	CDD:279295	25/107 (23%)
		Transglut_C	652..750	CDD:279295	27/98 (28%)
tgm1	XP_009294851.1	Transglut_N	52..169	CDD:279240	35/126 (28%)
		TGc	315..406	CDD:214673	52/94 (55%)
		Transglut_C	524..628	CDD:279295	25/105 (24%)
		Transglut_C	636..733	CDD:279295	27/98 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596884
Domainoid	1	1.000	133	1.000	Domainoid score	I5000
eggNOG	1	0.900	-	-		E1_2CD5G
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H306
Inparanoid	1	1.050	449	1.000	Inparanoid score	I1594
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	1	1.000	-	-		FOG0001456
OrthoInspector	1	1.000	-	-		otm24798
orthoMCL	1	0.900	-	-		OOG6_102867
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5185
SonicParanoid	1	1.000	-	-		X1344
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790