DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tg and tgm6

DIOPT Version :9

Sequence 1:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_001120399.1	Gene:	tgm6 / 100145475	XenbaseID:	XB-GENE-5878274	Length:	703	Species:	Xenopus tropicalis

Alignment Length:	707	Identity:	234/707 - (33%)
Similarity:	381/707 - (53%)	Gaps:	49/707 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 VLKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFTVADDTK 120
            |:..|.....|.:.|||..:    ..:.||:|||:||:|.:..||... :::.|.|||    :|.
Frog     7 VIACDWYYAVNEKAHHTDVY----ESDDLVLRRGQPFKLTLMLNRPLQ-AEENILFIF----ETG 62

  Fly   121 PSPGHGTLNALV-PHDGIDYLGDTLE-WGAGIESHEGQTLTVLIKPPSTCPVTEWKLDIDTKLLG 183
            |||...:...:| |.    :..:.|: |||.:.|.:..::||.|...|...:..:.|.:..:..|
Frog    63 PSPSETSKTKVVFPL----FRAENLQSWGAILTSIKSTSITVTINSHSDAVIGRYILSVAVQCRG 123

  Fly   184 DGSRSYPLPLP-----IYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVWKIG 243
            ...     |||     :.:|||||...|.|::.:.|||:||||::..:|::||...:....|:..
Frog   124 SDK-----PLPHQIGALNLLFNPWLQGDAVFMAEEDQRQEYVMNEQGVIFQGSDEDITSINWEYN 183

  Fly   244 QFERHVLECSLKVLGTVGR------IPPAYRGDPVRVARALSALVNSVDDDGVLLGNWSEDFSGG 302
            ||||::|:..|.:|.....      :..:.|.||:.|.|.|||::||..|||||..|||:|:..|
Frog   184 QFERNILDICLVILDRSQNYKKDPALDVSQRNDPLYVCRVLSAMLNSKGDDGVLEENWSDDYING 248

  Fly   303 VAPTKWTGSVEILQQFYKTQ-KSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTV 366
            .:|:.|.||:.||:.:|.:: |.||:.|||.::|:|.|:.||||||:|:||.::|..|..|:|.:
Frog   249 ASPSSWNGSMNILKSWYYSKFKPVKYGQCWVYAGMLCTVLRSLGIPTRVITHFNSGQDKNANLFI 313

  Fly   367 DV-FIDANNKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVG 430
            |: :....:::.|.|  |.:||:|||||.:.:|.|||    .:::||||:|:||.:.||.:|:.|
Frog   314 DLQYKSQGSRQNDQE--DQLWNFHVWNEAYFKRRDLG----KSYNGWQVIDSTPLKRSDGVYQCG 372

  Fly   431 PASVAAVKNGDILRPFDGGFVFAEVNADKLYWRY--NGPSQPLKLLRKDTLAIGHLISTKAVLKW 493
            ||.:.|:|.|||...:|..::||.||||...|.|  ||..:.:....|:|   |..|||||:...
Frog   373 PAPLTAIKEGDINLNYDVKYMFASVNADVACWIYYRNGTKKQVSNNAKET---GKFISTKAIGSN 434

  Fly   494 EREDITDTYKHAERSEEERSTMLKALKQSRHAF-SRYYLNDNFNDIEFDMELKDDI-KIGQSFSV 556
            :|.|:|:.||:|:.||:|.....||||.|:.:| .|........:|.|.....|.| ..||.|::
Frog   435 DRVDVTNNYKYAKGSEKEIKVFEKALKLSKGSFVGRTREKPRGGNILFGRCTLDQIATFGQDFNL 499

  Fly   557 VLKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVRMEVIFEEYYDKLS 621
            :|.:.|.:....:: |..|:..|:||||.....:.|.|..|.|.|.......:.|.:.:|...::
Frog   500 ILSLKNLTPDSINV-TVYINTSAILYTGRQRHTIWTGGKFLSLGPNLEKRFSIPVKYGQYSKHMT 563

  Fly   622 SQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQKELDVILRLENPLPIPLHKG 686
            ......::|..:|:.|:.....:.:..:.||.:...|.:.||:.| |.:..:.:.|||...|:..
Frog   564 DNGVICMTALCEVEGTEERILVERNVSLVKPPLSITLPDKAIINQ-ESNANIVIVNPLLETLNSC 627

  Fly   687 VFTVEGPGI-EQPLKFKIAEIPVGGTAAATFKYTPPYAGRGTMLAKFTSKELDDVDG 742
            :..|||.|: ::.||.::..:..|.::...|..||...|..|:|..|:..::.::.|
Frog   628 ILWVEGYGLTDKILKKEVPSLKPGQSSEHNFVITPMKTGVRTLLVNFSCDKIQNMKG 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	36/124 (29%)
		TGc	324..419	CDD:214673	41/95 (43%)
		Transglut_C	538..644	CDD:279295	26/106 (25%)
		Transglut_C	652..750	CDD:279295	25/92 (27%)
tgm6	NP_001120399.1	Transglut_N	6..119	CDD:279240	36/124 (29%)
		TGc	271..361	CDD:214673	41/95 (43%)
		Transglut_C	494..581	CDD:279295	22/87 (25%)
		Transglut_C	594..691	CDD:279295	25/92 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020