DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Dc and SERPINB7

DIOPT Version :9

Sequence 1:	NP_609172.1	Gene:	Spn28Dc / 34091	FlyBaseID:	FBgn0031973	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001035237.1	Gene:	SERPINB7 / 8710	HGNCID:	13902	Length:	380	Species:	Homo sapiens

Alignment Length:	442	Identity:	114/442 - (25%)
Similarity:	187/442 - (42%)	Gaps:	88/442 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 ANSVLNFANILGQHLANGKTQIYSPLSIVHSLALLLLGAKGRSYEELSTVFDIPDTS----RLHE 169
            |....|....:..:..||.. .:|.||:..:|||:.|||:..|..::..:..:...|    ..:.
Human     9 AEFCFNLFREMDDNQGNGNV-FFSSLSLFAALALVRLGAQDDSLSQIDKLLHVNTASGYGNSSNS 72

  Fly   170 QFGLMLQDLQQPTREAISAGRPLTDWRASSAMRSNRRAQRPGAHEVHLANGLFTQTGYTLNPDYR 234
            |.||..|           ..|..:|..||..           .:::.:.||||.:..|..:.||.
Human    73 QSGLQSQ-----------LKRVFSDINASHK-----------DYDLSIVNGLFAEKVYGFHKDYI 115

  Fly   235 RVIVEVYASDLQIQDFEGSPATARYNINAYVAQHTKNHIENIIA-SDIPQTTRMILANALYFKAF 298
            ....::|.:.::..||.......|.|||.:|...|...|:|:|. ..|..:..|:|.||:|||..
Human   116 ECAEKLYDAKVERVDFTNHLEDTRRNINKWVENETHGKIKNVIGEGGISSSAVMVLVNAVYFKGK 180

  Fly   299 WETDFIESATRPDNF-YPNGEGTEPVMRVQMMATGGAYPYHEDHEL--------GCKIIGLPYRG 354
            |::.|.:|.|...:| .|...|    ..|.||        |::.:.        ..||:.|.|.|
Human   181 WQSAFTKSETINCHFKSPKCSG----KAVAMM--------HQERKFNLSVIEDPSMKILELRYNG 233

  Fly   355 NLSTMYIIQPFKSSVRELMALQKRLTADKIESMIS--RMYRRAALVAFPKMHLTESVNLKTVMQR 417
            .:: ||::.|    ..:|..::.:||...:....:  ||..:...|.||:..:.::..:|..::.
Human   234 GIN-MYVLLP----ENDLSEIENKLTFQNLMEWTNPRRMTSKYVEVFFPQFKIEKNYEMKQYLRA 293

  Fly   418 MGLGGIFSAVQNDLSLIATNEATRTNALGGNSLQNLEAQRRAGTGGARSDLVVDDIVHKVDFTVN 482
            :||..||...:.|||.||:         ||.                   |.:..::||....|.
Human   294 LGLKDIFDESKADLSGIAS---------GGR-------------------LYISRMMHKSYIEVT 330

  Fly   483 EQGTEA-AASSVTYLKKSGP-DVLFRGDTPFMVLVRHDPTKLVLFYGLINEP 532
            |:|||| ||:....::|..| ..|||.|.||:.::|.|  .::||.|.::.|
Human   331 EEGTEATAATGSNIVEKQLPQSTLFRADHPFLFVIRKD--DIILFSGKVSCP 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Dc	NP_609172.1	SERPIN	111..527	CDD:238101	111/433 (26%)
SERPINB7	NP_001035237.1	serpinB7_megsin	1..380	CDD:381032	113/440 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910