DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn28Dc and SERPINA6

DIOPT Version :9

Sequence 1:	NP_609172.1	Gene:	Spn28Dc / 34091	FlyBaseID:	FBgn0031973	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001747.3	Gene:	SERPINA6 / 866	HGNCID:	1540	Length:	405	Species:	Homo sapiens

Alignment Length:	451	Identity:	111/451 - (24%)
Similarity:	196/451 - (43%)	Gaps:	92/451 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 YVDLATSDR-IANSVLNFANILGQHLA--NGKTQIY-SPLSIVHSLALLLLGAKGRSYEEL--ST 157
            ||:::...| :|::.::||..|.:||.  :.|..|: ||:||..:||:|.||..|.:..:|  ..
Human    29 YVNMSNHHRGLASANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGL 93

  Fly   158 VFDIPDTS--RLHEQFGLMLQDLQQPTREAISAGRPLTDWRASSAMRSNRRAQRPGAHEVHLANG 220
            .|::.:.|  .:|:.|    |.|.|                        ..|:...:.|:.:.|.
Human    94 GFNLTERSETEIHQGF----QHLHQ------------------------LFAKSDTSLEMTMGNA 130

  Fly   221 LFTQTGYTLNPDYRRVIVEVYASDLQIQDFEGSPATARYNINAYVAQHTKNHIENIIASDIPQTT 285
            ||......|...:...|...|.|::...:|: ..|||...||:||...|:..|.::. |.:....
Human   131 LFLDGSLELLESFSADIKHYYESEVLAMNFQ-DWATASRQINSYVKNKTQGKIVDLF-SGLDSPA 193

  Fly   286 RMILANALYFKAFWETDFIESATRPDNFYPNGEGTEPVMRVQMMATGGAYPYHEDHELGCKIIGL 350
            .::|.|.::||..|...|..::||.:|||.: |.|  |::|.||.......|..|.||.|:::.:
Human   194 ILVLVNYIFFKGTWTQPFDLASTREENFYVD-ETT--VVKVPMMLQSSTISYLHDSELPCQLVQM 255

  Fly   351 PYRGNLSTMYIIQPFKSSVRELMALQKR---------LTADKIESMISRMYRRAALVAFPKMHLT 406
            .|.|| .|::.|.|.|..:..::|...|         ||:.:::..|            ||:.::
Human   256 NYVGN-GTVFFILPDKGKMNTVIAALSRDTINRWSAGLTSSQVDLYI------------PKVTIS 307

  Fly   407 ESVNLKTVMQRMGLGGIFSAVQNDLSLIATNEATRTNALGGNSLQNLEAQRRAGTGGARSDLVVD 471
            ...:|..|::.||:..:|           ||:|..:..       ..:||.::           .
Human   308 GVYDLGDVLEEMGIADLF-----------TNQANFSRI-------TQDAQLKS-----------S 343

  Fly   472 DIVHKVDFTVNEQGTEAAASSVTYLKKSGPDVLFRGDTPFMVLVRHDPTKLVLFYGLINEP 532
            .:|||....:||:|.:.|.|:...|..:...::.|.:.||::::....|...||...:..|
Human   344 KVVHKAVLQLNEEGVDTAGSTGVTLNLTSKPIILRFNQPFIIMIFDHFTWSSLFLARVMNP 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Dc	NP_609172.1	SERPIN	111..527	CDD:238101	106/431 (25%)
SERPINA6	NP_001747.3	alpha-1-antitrypsin_like	42..401	CDD:239011	106/433 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010