DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn28Dc and Serpind1

DIOPT Version :9

Sequence 1:	NP_609172.1	Gene:	Spn28Dc / 34091	FlyBaseID:	FBgn0031973	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_077358.1	Gene:	Serpind1 / 79224	RGDID:	619854	Length:	479	Species:	Rattus norvegicus

Alignment Length:	560	Identity:	130/560 - (23%)
Similarity:	218/560 - (38%)	Gaps:	118/560 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WRLLLALLLVSSVCCESELFRDDLRTPETMAYINGLMQRRHQMQQEAQQHIQAIPPAVPLQSPGL 66
            :.|||:|::  |:|..|:...:.| |.|.:.                   :..:||....::...
  Rat     6 YTLLLSLIM--SMCAGSKGLAEQL-TKENLT-------------------VSLLPPNFHKENTVT 48

  Fly    67 VNGL--GNQNDPALNRISGTS-----------VKPSNLPAAYSNGYVDLATSDRI-------ANS 111
            .:.:  |.::|..|:.....|           |.|::..::..|.........||       |..
  Rat    49 NDWIPEGEEDDDYLDLEKLLSEDDDYIYVVDAVSPTDSESSAGNILQLFQGKSRIQRLNILNAKF 113

  Fly   112 VLNFANILGQHLANGKTQIYSPLSIVHSLALLLLGAKGRSYEELSTVFDIPD---------TSRL 167
            ..|...:|.....:......:|:.|..::.::.||.:|.::||:.:|....|         .:.:
  Rat   114 AFNLYRVLKDQATSSDNIFIAPVGISTAMGMISLGLRGETHEEVHSVLHFKDFVNASSKYEVTTI 178

  Fly   168 HEQFGLMLQDLQQPTREAISAGRPLTDWRASSAMRSNRRAQRPGAHEVHLANGLFTQTGYTLNPD 232
            |..|                  |.||          :|..:|...:.:...|.|:.|..:.:..|
  Rat   179 HNLF------------------RKLT----------HRLFRRNFGYTLQSVNDLYIQKQFPIRED 215

  Fly   233 YRRVIVEVYASDLQIQDFEGSPATARYNINAYVAQHTKNHIENIIASDIPQTTRMILANALYFKA 297
            ::..:.|.|.::.|..|| ..||... ..|:::.:.||..|:..: .:....|:|::.|.:|||.
  Rat   216 FKAAMREFYFAEAQEADF-SDPAFIS-KANSHILKLTKGLIKEAL-ENTDSATQMMILNCIYFKG 277

  Fly   298 FWETDFIESATRPDNFYPNGEGTEPVMRVQMMATGGAYPYHEDHELGCKIIGLPYRGNLSTMYII 362
            .|...|....|...||..|   ...|::|.||.|.|.:....|.||.|.|:.|.|.|.:| |.|:
  Rat   278 AWMNKFPVEMTHNHNFRLN---EREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGIS-MLIV 338

  Fly   363 QPFKSSVRELMALQKRLTADKIESMISRMYRRAALVAFPKMHLTESVNLKTVMQRMGLGGIFSAV 427
            .|.|.|  .:..|:.:||...:|.....|..|...|..||..|.::.||..|::.||:..:|:.
  Rat   339 IPRKLS--GMKTLEAQLTPQVVERWQKSMTNRTREVLLPKFKLEKNYNLVEVLKSMGITKLFNK- 400

  Fly   428 QNDLSLIATNEATRTNALGGNSLQNLEAQRRAGTGGARSDLVVDDIVHKVDFTVNEQGTEAAASS 492
                              .|| :..:..||          :::|...|:...||||:||:|||.:
  Rat   401 ------------------NGN-MSGISDQR----------IIIDLFKHQSTITVNEEGTQAAAVT 436

  Fly   493 VTYLKKSGPDVLFRGDTPFMVLVRHDPTKLVLFYGLINEP 532
            ..........|.|..|.||:.||....|..:||.|.:..|
  Rat   437 TVGFMPLSTQVRFTVDRPFLFLVYEHRTSCLLFMGRVANP 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Dc	NP_609172.1	SERPIN	111..527	CDD:238101	106/424 (25%)
Serpind1	NP_077358.1	HCII	44..477	CDD:239002	118/500 (24%)
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	55..79		4/23 (17%)
		Glycosaminoglycan-binding site. /evidence=ECO:0000250	172..192		6/47 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010