DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Dc and Serpina12

DIOPT Version :9

Sequence 1:	NP_609172.1	Gene:	Spn28Dc / 34091	FlyBaseID:	FBgn0031973	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_080811.1	Gene:	Serpina12 / 68054	MGIID:	1915304	Length:	413	Species:	Mus musculus

Alignment Length:	440	Identity:	113/440 - (25%)
Similarity:	194/440 - (44%)	Gaps:	89/440 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 RIANSVLNFANILGQHLANGKTQ---IYSPLSIVHSLALLLLGAKGRSYEELSTVFDIPDTSR-- 166
            ::|...:.|...|.|.||:...|   ..|||||..:.::|.|||:..:.||:...|:..:.|.
Mouse    47 QLARHNMEFGFKLLQRLASNSPQGNIFLSPLSISTAFSMLSLGAQNSTLEEIREGFNFKEMSNWD 111

  Fly   167 LHEQFGLMLQDLQQPTREAISAGRPLTDWRASSAMRSNRRAQRPGAHEVHLANGLFTQTGYTLNP 231
            :|..|..:|..|.|.|.:.                            :::|.|.||..  ..|.|
Mouse   112 VHAAFHYLLHKLNQETEDT----------------------------KMNLGNALFMD--QKLRP 146

  Fly   232 DYR--RVIVEVYASDLQIQDFEGSPATARYNINAYVAQHTKNHIENIIASDIPQTTRMILANALY 294
            ..|  .:...||.:|:.:.:|:....|.: :||.|::|.|.:.|:|::.|..|.|. |||.|.:|
Mouse   147 QQRFLNLAKNVYDADMVLTNFQDLENTQK-DINRYISQKTHSRIKNMVKSIDPGTV-MILTNYIY 209

  Fly   295 FKAFWETDFIESATRPDNFYPNGEGTEPVMRVQMMATGGAYPYHEDHELGCKIIGLPYRGNLSTM 359
            |:..|:.:|....|:.:.|:.....|   ::|.||...|.|....|.:|.|.|:.:|||||::..
Mouse   210 FRGRWQYEFDPKQTKEEEFFIEKGKT---VKVPMMFQRGLYDMAYDSQLSCTILEIPYRGNITAT 271

  Fly   360 YIIQPFKSSVRELMALQKRLTADKIESMISRMYRRAALVAFPKMHLTESVNLKTVMQRMGLGGIF 424
            ::: |...   :|..|::.|.||......|.:.:|...|..||:.::.:.|:|.|:.|:|:..||
Mouse   272 FVL-PDNG---KLKLLEQGLQADIFAKWKSLLSKRVVDVWVPKLRISSTYNMKKVLSRLGISKIF 332

  Fly   425 SAVQNDLSLIATNEATRTNALGGNSLQNLEAQRRAGTGGARSDLVVDDIVHKVDFTVNEQGTEAA 489
            .. ..||:.|:::.:                            |.|.:.|||.:..::|:|.|.|
Mouse   333 EE-NGDLTRISSHRS----------------------------LKVGEAVHKAELKMDEKGMEGA 368

  Fly   490 ASSVTYLKKSGPDVL-------FRGDTPFMVLVRHDPTKLVLFYGLINEP 532
            |.       ||...|       .:.|.||::::..:....::|...|.:|
Mouse   369 AG-------SGAQTLPMETPRHMKLDRPFLMMIYENFMPSMVFLARIYDP 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Dc	NP_609172.1	SERPIN	111..527	CDD:238101	110/429 (26%)
Serpina12	NP_080811.1	alpha-1-antitrypsin_like	51..408	CDD:239011	110/431 (26%)
Serpina12	NP_080811.1	Reactive center loop. /evidence=ECO:0000250\|UniProtKB:Q8IW75	364..382		7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D491891at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020