DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn28Dc and serpinf2b

DIOPT Version :9

Sequence 1:	NP_609172.1	Gene:	Spn28Dc / 34091	FlyBaseID:	FBgn0031973	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001073479.1	Gene:	serpinf2b / 563663	ZFINID:	ZDB-GENE-061215-114	Length:	479	Species:	Danio rerio

Alignment Length:	562	Identity:	131/562 - (23%)
Similarity:	223/562 - (39%)	Gaps:	141/562 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LALLLVSSVCCESELFRDDLRTPETMAYINGLMQRRHQMQQEAQQHIQAIPPAVPLQSPGLVNGL 70
            ||.||   :|...:.:.||:..||                    ..:..:.|.:||.....::.|
Zfish     6 LAFLL---LCYSKQGWTDDVTDPE--------------------DGVDPVIPLIPLTPSKPISDL 47

  Fly    71 GNQNDPALNRISGTSVKPSNLPA-----AYSNGYVDLATSDR-----------------IANSVL 113
            ....||.:..:   :|.|..|.|     ..::|..:.::.:.                 |.|.::
Zfish    48 KATLDPTVTEV---TVNPDGLEADPPTPGLTSGLKEGSSEEELDTLCDGDMTGKQIKRTIGNGIM 109

  Fly   114 NFANILGQHLANGKTQ---IYSPLSIVHSLALLLLGAKGRSYEELSTVFDIPDTSRLHEQFGLML 175
            ....:..::|.....|   |:||||:..:|:.|.|||...:.|                   |:|
Zfish   110 KLGLLFLENLKPSPDQPNVIFSPLSLSVALSQLALGATNDTEE-------------------LLL 155

  Fly   176 QDLQQPTREAISAGRPLTDWRASSAMRSNRRAQRPGAHEVHLANGLFTQTGYTLNPDYRRVIVEV 240
            ..|.   .:|:    |......||.:|:.|:...|      :|:.::.:||:....|:.....::
Zfish   156 HHLH---ADAL----PCYHTALSSLLRNFRKRSMP------IASRIYLKTGFKAKSDFMEDSQKL 207

  Fly   241 YASDLQIQDFEGSPATAR--YNINAYVAQHTKNHIENIIASDIPQTTRMILANALYFKAFWETDF 303
            |.|:         |||..  .::|.:|.:.|..||...::| :|.:..|:|.||:::|..|.|.|
Zfish   208 YDSE---------PATLTDVNDVNEWVKKVTNGHISEFLSS-LPPSAVMMLINAMHYKGEWLTRF 262

  Fly   304 IESATRPDNFYPNGEGTEPVMRVQMMATGGAYP--YHEDHELGCKIIGLPYRGNLSTMYIIQPFK 366
            ....|..:|||.:   ...::.|.|| .|..||  ....|||..::...|::|:.| :.::.|..
Zfish   263 DPHFTSTENFYID---ENQIVNVDMM-LGPKYPLSVFTHHELDAQVARFPFKGDRS-LLVVMPTS 322

  Fly   367 SSVRELMALQKRLTADKIESMISRMYR-RAALVAFPKMHLTESVNLKTVMQRMGLGGIFSAVQND 430
            ..| .:.|:..:|   .|..:.||:.| |...|..||..|..:.:|:..|..||||.:||..:.|
Zfish   323 GHV-NVSAIAAKL---NISDLYSRLPRERNMQVKLPKFKLDFNQDLQEAMTSMGLGKLFSHPKLD 383

  Fly   431 LSLIATNEATRTNALGGNSLQNLEAQRRAGTGGARSDLVVDDIVHKVDFTVNEQGTEAAASSVTY 495
                                       |...|    .|.|..:.|.....:||:|.||.|::...
Zfish   384 ---------------------------RITEG----PLFVSSVQHMSSVEINEEGAEAVAATSVV 417

  Fly   496 LKKSGPDVLFRGDTPFMVLVRHDPTKLVLFYGLINEP-PAAA 536
            :.:|.|.  |..:.||...:..|.::..||.|:|:.| |.|:
Zfish   418 ISRSNPS--FTVNQPFFFALMDDLSQTPLFLGVISNPNPGAS 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Dc	NP_609172.1	SERPIN	111..527	CDD:238101	104/423 (25%)
serpinf2b	NP_001073479.1	SERPIN	106..449	CDD:294093	106/426 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100