DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Dc and SERPINB5

DIOPT Version :9

Sequence 1:	NP_609172.1	Gene:	Spn28Dc / 34091	FlyBaseID:	FBgn0031973	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_002630.2	Gene:	SERPINB5 / 5268	HGNCID:	8949	Length:	375	Species:	Homo sapiens

Alignment Length:	439	Identity:	99/439 - (22%)
Similarity:	181/439 - (41%)	Gaps:	81/439 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 RIANSVLNFANILGQHLANGK---TQIYSPLSIVHSLALLLLGAKGRSYEELSTVFDIPDTSRLH 168
            ::|||.  ||..|.:.|...:   ..::||:.:..||:|..:||||.:..|:..|....:...:.
Human     5 QLANSA--FAVDLFKQLCEKEPLGNVLFSPICLSTSLSLAQVGAKGDTANEIGQVLHFENVKDVP 67

  Fly   169 EQFGLMLQDLQQPTREAISAGRPLTDWRASSAMRSNRRAQRPGAHEVHLANGLFTQTGYTLNPDY 233
            ..|..:..|:.                :.||            .:.:.|...|:......|:.::
Human    68 FGFQTVTSDVN----------------KLSS------------FYSLKLIKRLYVDKSLNLSTEF 104

  Fly   234 RRVIVEVYASDLQIQDFEGSPATARYNINAYVAQHTKNHIENIIA-SDIPQTTRMILANALYFKA 297
            .......||.:|:..||:......:..||..:...|..|.|||:| :.:...|::::.||.||..
Human   105 ISSTKRPYAKELETVDFKDKLEETKGQINNSIKDLTDGHFENILADNSVNDQTKILVVNAAYFVG 169

  Fly   298 FWETDFIESATRPDNFYPNGEGTEPVMRVQMMATGGAYPYHEDHELGCKIIGLPYRGNLSTMYII 362
            .|...|.||.|:...|..|...|:||..:.|.||   :.......:.||||.||::....:|:|:
Human   170 KWMKKFSESETKECPFRVNKTDTKPVQMMNMEAT---FCMGNIDSINCKIIELPFQNKHLSMFIL 231

  Fly   363 QP--FKSSVRELMALQKRLTADKIESMI--SRMYRRAALVAFPKMHLTESVNLKTVMQRMGLGGI 423
            .|  .:.....|..::|:|.::.:....  |.|......::.||..:.:.::.|..::.:||..|
Human   232 LPKDVEDESTGLEKIEKQLNSESLSQWTNPSTMANAKVKLSIPKFKVEKMIDPKACLENLGLKHI 296

  Fly   424 FSAVQNDLSLIATNEATRTNALGGNSLQNLEAQRRAGTGGARSDLVVDDIVHKVDFTVNEQGTEA 488
            ||...:|.|.::..:        |.:|.|                    ::|||...:.|.|.::
Human   297 FSEDTSDFSGMSETK--------GVALSN--------------------VIHKVCLEITEDGGDS 333

  Fly   489 AASSVTYLKKSGPDVL-----FRGDTPFMVLVRHDPTKLVLFYGLINEP 532
                   ::..|..:|     ...|.||:.::||:.|:.::|:|....|
Human   334 -------IEVPGARILQHKDELNADHPFIYIIRHNKTRNIIFFGKFCSP 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Dc	NP_609172.1	SERPIN	111..527	CDD:238101	95/428 (22%)
SERPINB5	NP_002630.2	maspin_like	4..375	CDD:239012	98/437 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910