DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Dc and serpina1

DIOPT Version :9

Sequence 1:	NP_609172.1	Gene:	Spn28Dc / 34091	FlyBaseID:	FBgn0031973	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	XP_017207927.1	Gene:	serpina1 / 322701	ZFINID:	ZDB-GENE-030131-1421	Length:	433	Species:	Danio rerio

Alignment Length:	441	Identity:	105/441 - (23%)
Similarity:	187/441 - (42%)	Gaps:	99/441 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 NFANILGQHLAN-----GKTQIYSPLSIVHSLALLLLGAKGRSYEELSTVFDIPDTSRLHEQFGL 173
            :||..|.:.||:     ||...:||:.|..:|:||.:|||..:   ||.::.           ||
Zfish    72 DFAFSLYKKLASNPDGQGKNIFFSPVGISMALSLLAVGAKAST---LSQIYS-----------GL 122

  Fly   174 MLQDLQQPTREAISAGRPLTDWRASSAMRSNRRAQRPGAHEVHLAN------------GLFTQTG 226
            ....|   |.|.::.|.                     .|.:|:..            |:..:.|
Zfish   123 GYSAL---TPEQVNEGY---------------------EHLLHMLGHSQDAMQLEAGAGVAIRDG 163

  Fly   227 YTLNPDYRRVIVEVYASDLQIQDFEGSPATARYNINAYVAQHTKNHIENIIASDIPQTTRMILAN 291
            :.:...:.:.....|.|:....|| ..|..|...||.::|:.|.:.|.|:: .|:...|.|:|.|
Zfish   164 FKVVDQFLKDAQHYYNSEAFGVDF-SKPEIAAAEINKFIARKTHDKITNMV-KDLDADTVMMLIN 226

  Fly   292 ALYFKAFWETDFIESATRPDNFYPNGEGTEPVMRVQMMATGGAYPYHEDHELGCKIIGLPYRGNL 356
            .:||:..||..|....|...:|..:.:.|   ::|.||...|.|..::|......::.:||:||.
Zfish   227 YMYFRGKWEKPFDAKLTHKADFKVDQDTT---VQVDMMKRTGRYDIYQDPVNQTTVMMVPYKGNT 288

  Fly   357 STMYIIQPFKSSVRELMALQKRLTADKIESMISRMYRRAALVAFPKMHLTESVNLKTVMQRMGLG 421
            | |.|:.|....::|   |::.:....:::...:::|.:..:..||..::.:..|..:::.||:.
Zfish   289 S-MMIVLPDDGKMKE---LEESICRHHLKNWHDKLFRSSVDLFMPKFSISATSKLDGILKDMGMT 349

  Fly   422 GIFSAVQNDLSLIATNEATRTNALGGNSLQNLEAQRRAGTGGARSD--LVVDDIVHKVDFTVNEQ 484
            ..|    ||                           :|...|...:  :.|..::|:...:|:|:
Zfish   350 DAF----ND---------------------------KADFSGMTEEVKVKVSQVLHQAVMSVDEK 383

  Fly   485 GTEAAA-SSVTYLKKSGPDVLFRGDTPFMVLVRHDPTKLVLFYGLINEPPA 534
            |||||| :::..:..|.||.:.. :.||:||:..|.|..:||.|.|..|.|
Zfish   384 GTEAAAITTIEIMPMSLPDTVIL-NRPFLVLIVEDSTMSILFMGKITNPTA 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Dc	NP_609172.1	SERPIN	111..527	CDD:238101	101/432 (23%)
serpina1	XP_017207927.1	alpha-1-antitrypsin_like	69..428	CDD:239011	102/434 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D491891at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020