Protein Alignment Spn28Dc and SERPIND1

DIOPT Version :10

• Sequence 1: NP_609172.1
• Gene: Spn28Dc / 34091
• FlyBaseID: FBgn0031973
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_000176.2
• Gene: SERPIND1 / 3053
• HGNCID: 4838
• Length: 499
• Species: Homo sapiens
• Alignment Length: 477
• Identity: 114/477 - (23%)
• Similarity: 188/477 - (39%)
• Gaps: 83/477 - (17%)

  Fly    72 NQNDPALNRISGTSVKPSNLPAAYSNGYVDLATSDRI-------ANSVLNFANILGQHLANGKTQ 129
            :::|..::.:...||.|::...:..|.........||       |....|...:|...:......
Human    87 SEDDDYIDIVDSLSVSPTDSDVSAGNILQLFHGKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNI 151

  Fly   130 IYSPLSIVHSLALLLLGAKGRSYEELSTVFDIPD---------TSRLHEQFGLMLQDLQQPTREA 185
            ..:|:.|..::.::.||.||.::|::.::....|         .:.:|..|
Human   152 FIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLF-------------- 202

  Fly   186 ISAGRPLTDWRASSAMRSNRRAQRPGAHEVHLANGLFTQTGYTLNPDYRRVIVEVYASDLQIQDF 250
                |.||          :|..:|...:.:...|.|:.|..:.:..|::..:.|.|.::.||.||
Human   203 ----RKLT----------HRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADF 253

  Fly   251 EGSPATARYNINAYVAQHTKNHIENIIASDIPQTTRMILANALYFKAFWETDFIESATRPDNFYP 315
             ..||... ..|.::.:.||..|::.: .:|...|:|::.|.:|||..|...|....|...||..
Human   254 -SDPAFIS-KTNNHIMKLTKGLIKDAL-ENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRL 315

  Fly   316 NGEGTEPVMRVQMMATGGAYPYHEDHELGCKIIGLPYRGNLSTMYIIQPFKSSVRELMALQKRLT 380
            |   ...|::|.||.|.|.:....|.||.|.|:.|.|.|.:| |.|:.|.|.|  .:..|:.:||
Human   316 N---EREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGIS-MLIVVPHKMS--GMKTLEAQLT 374

  Fly   381 ADKIESMISRMYRRAALVAFPKMHLTESVNLKTVMQRMGLGGIFSAVQNDLSLIATNEATRTNAL 445
            ...:|.....|..|...|..||..|.::.||...::.||:..:|..
Human   375 PRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDK------------------- 420

  Fly   446 GGNSLQNLEAQRRAGTGGARSDLVVDDIVHKVDFTVNEQGTEAAASSVTYLKKSGPDVLFRGDTP 510
            .||         .||....|  :.:|...|:...||||:||:|...:..........|.|..|.|
Human   421 NGN---------MAGISDQR--IAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRP 474

  Fly   511 FMVLVRHDPTKLVLFYGLINEP 532
            |:.|:....|..:||.|.:..|
Human   475 FLFLIYEHRTSCLLFMGRVANP 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Dc	NP_609172.1	serpin28D-like_insects	111..532	CDD:381061	105/429 (24%)
SERPIND1	NP_000176.2	serpinD1_HCF2	51..499	CDD:381004	114/477 (24%)
		Chemotactic activity	68..79
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	73..97		1/9 (11%)
		Glycosaminoglycan-binding site	192..212		6/47 (13%)