DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Dc and Serpina3b

DIOPT Version :9

Sequence 1:	NP_609172.1	Gene:	Spn28Dc / 34091	FlyBaseID:	FBgn0031973	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_766612.1	Gene:	Serpina3b / 271047	MGIID:	2182835	Length:	420	Species:	Mus musculus

Alignment Length:	481	Identity:	110/481 - (22%)
Similarity:	197/481 - (40%)	Gaps:	114/481 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 IPPAVPLQSPGLVNGLGN---QNDPALNRISGTSVKPSNLPAAYSNGYVDLATSDRIANSVLNFA 116
            |.|||...|.|.: |:.|   :......::...::...|...|:| .|.:||    :.|...|.|
Mouse    14 ICPAVICCSDGTL-GMHNAVQKGQDTQKQLDSLTLASINTDFAFS-FYKELA----LKNPHKNIA 72

  Fly   117 NILGQHLANGKTQIYSPLSIVHSLALLLLGAKGRSYEELSTV--FDIPDTSR--LHEQFGLMLQD 177
                          :||..|..:|..|.|||||.:.||:..|  |::.:||.  :|:.|..:||.
Mouse    73 --------------FSPFGIATALNSLTLGAKGNTLEEILEVLKFNLTETSEADIHQGFKHLLQR 123

  Fly   178 LQQPTREAISAGRPLTDWRASSAMRSNRRAQRPGAHEVHLANGLFTQTGYTLNPDYRRVIVEVYA 242
            |..|..:.                            ::...|.||.:....:..:::.....:|.
Mouse   124 LSHPGDQV----------------------------QIRTGNALFVEKHLQILAEFKEKARALYH 160

  Fly   243 SDLQIQDFEGSPATARYNINAYVAQHTKNHIENIIASDIPQTTRMILANALYFKAFWETDFIESA 307
            :::...:|: .|..|...||:|::..|:..|:.:: ||:...|.|::.|.|:|||.|...|....
Mouse   161 TEVFTANFQ-QPHEAMKLINSYMSNQTQGKIKELV-SDMDGNTSMVIVNDLFFKAEWMVPFNSDD 223

  Fly   308 TRPDNFYPNGEG--TEPVMRVQMMATGGAYPYHEDHELGCKIIGLPYRGNLSTMYII------QP 364
            |....|..:...  ..|:|:.:.:.|    ||..|.||.|.::.|.|:||...|:|:      |.
Mouse   224 TFMGKFIVDRSRHVKVPMMKTKNLRT----PYFRDEELKCTVVELNYKGNGKAMFILPDQGKMQQ 284

  Fly   365 FKSSVR--ELMALQKRLTADKIESMISRMYRRAALVAFPKMHLTESVNLKTVMQRMGLGGIFSAV 427
            .::|::  .|...:|.|...||:.:           ..||..|::..||:.::..:|:..:|| .
Mouse   285 VEASLQPGTLKKWRKSLRPRKIKEL-----------HLPKFSLSQHYNLEDILPELGIRELFS-T 337

  Fly   428 QNDLSLIATNEATRTNALGGNSLQNLEAQRRAGTGGARSDLVVDDIVHKVDFTVNEQGTEAAASS 492
            |.|||                           |..|.: ::.|.:::|..:..:.|:|||..|.:
Mouse   338 QADLS---------------------------GITGVK-NITVSEMIHSTELDMTEKGTEGDAIT 374

  Fly   493 V---TYLKKSGPDVLFRGDTPFMVLV 515
            :   .::......|..:.:..|:.:|
Mouse   375 IVGYNFMSAKLKPVFVKFEDQFLYIV 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Dc	NP_609172.1	SERPIN	111..527	CDD:238101	95/422 (23%)
Serpina3b	NP_766612.1	SERPIN	51..414	CDD:294093	102/443 (23%)
Serpina3b	NP_766612.1	RCL	367..392		5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D491891at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020