DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn28Dc and Serpina3f

DIOPT Version :9

Sequence 1:	NP_609172.1	Gene:	Spn28Dc / 34091	FlyBaseID:	FBgn0031973	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001028507.2	Gene:	Serpina3f / 238393	MGIID:	2182838	Length:	445	Species:	Mus musculus

Alignment Length:	479	Identity:	128/479 - (26%)
Similarity:	203/479 - (42%)	Gaps:	104/479 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 DPALNRISGTSVKPSNLPAAYSNGYVDLATSDRIANSVLNFANILGQHLA---NGKTQIYSPLSI 136
            |..|.|.:.......|:.:      ||..|   :|:|..:||..|.:.|.   ..:..::||.||
Mouse    13 DVTLGRNTAVREVQENITS------VDSLT---LASSNTDFAFSLYKELVLKNPDENVVFSPFSI 68

  Fly   137 VHSLALLLLGAKGRSYEEL--STVFDIPDTSR--LHEQFGLMLQDLQQPTREA-ISAGRPLTDWR 196
            ..:||||.||||..:.:|:  ...|::.:|..  :|:.|..:|..|.||..:. ||.|
Mouse    69 CTALALLSLGAKSNTLKEILEGLKFNLTETPEPDIHQGFRYLLDLLSQPGNQVQISTG------- 126

  Fly   197 ASSAMRSNRRAQRPGAHEVHLANGLFTQTGYTLNPDYRRVIVEVYASDLQIQDFEGSPATARYNI 261
                                  :.||.:....:..:::.....:|.::....||: .|..|...|
Mouse   127 ----------------------SALFIEKHLQILAEFKEKARALYQAEAFTADFQ-QPLEATKLI 168

  Fly   262 NAYVAQHTKNHIENIIASDIPQTTRMILANALYFKAFWETDFIESATRPDNFY--PNGEGTEPVM 324
            |.||:.||:..|:.:| ||:.:.|.|:|.|.:|||..||..|....|....||  .|.....|:|
Mouse   169 NDYVSNHTQGKIKELI-SDLDKRTLMVLVNYIYFKGKWEMPFDPDDTCKSEFYLDENRSVKVPMM 232

  Fly   325 RVQMMATGGAYPYHEDHELGCKIIGLPYRGNLSTMYIIQPFKSSVRELMA-LQKRLTADKIESMI 388
            ::..:.|    ||..|.||.|.::.|.|.||.|.|:|: |.:..::::.| ||.....:..:|:.
Mouse   233 KINNLTT----PYFRDEELSCTVVELKYTGNASAMFIL-PDQGKMQQVEASLQPETLRNWKDSLK 292

  Fly   389 SRMYRRAALVAFPKMHLTESVNLKTVMQRMGLGGIFSAVQNDLSLIATNEATRTNALGGNSLQNL 453
            .|:.....|   ||..::...:|:.::..:|:..:|| .|.|||.|
Mouse   293 PRLINELCL---PKFSISTDYSLEHILPELGIRELFS-TQADLSAI------------------- 334

  Fly   454 EAQRRAGTGGARSDLVVDDIVHKVDFTVNEQGTEAAASS----------VTYLKKSGPDVLFRGD 508
                 .||    .||....:|||....|.|.||||||.:          |.|..|    :.|  |
Mouse   335 -----TGT----KDLRTSQVVHKAVLDVAETGTEAAAGTGYQNLQCCQGVIYSMK----IYF--D 384

  Fly   509 TPFMVLVRHDPTKLVLFYGLINEP 532
            .||::::....|.:.||...::.|
Mouse   385 RPFLMIISDTNTHIALFMAKVSNP 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Dc	NP_609172.1	SERPIN	111..527	CDD:238101	119/436 (27%)
Serpina3f	NP_001028507.2	alpha-1-antitrypsin_like	40..405	CDD:239011	119/438 (27%)
Serpina3f	NP_001028507.2	RCL	357..382		9/28 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D491891at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020