DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Dc and Serpina1a

DIOPT Version :9

Sequence 1:	NP_609172.1	Gene:	Spn28Dc / 34091	FlyBaseID:	FBgn0031973	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001239498.1	Gene:	Serpina1a / 20700	MGIID:	891971	Length:	436	Species:	Mus musculus

Alignment Length:	438	Identity:	111/438 - (25%)
Similarity:	187/438 - (42%)	Gaps:	78/438 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 SDRIANSVLNFANILGQ---HLANGKTQIYSPLSIVHSLALLLLGAKGRSYEEL--STVFDIPDT 164
            |..||.::.:||..|.:   |.:|.....:||:||..:.|:|.||:||.::.::  ...|::..|
Mouse    64 SHEIATNLGDFAISLYRELVHQSNTSNIFFSPVSIATAFAMLSLGSKGDTHTQILEGLQFNLTQT 128

  Fly   165 SR--LHEQFGLMLQDLQQPTRE-AISAGRPLTDWRASSAMRSNRRAQRPGAHEVHLANGLFTQTG 226
            |.  :|:.|..:||.|.:|..| .:|.|                             ||||....
Mouse   129 SEADIHKSFQHLLQTLNRPDSELQLSTG-----------------------------NGLFVNND 164

  Fly   227 YTLNPDYRRVIVEVYASDLQIQDFEGSPATARYNINAYVAQHTKNHIENIIASDIPQTTRMILAN 291
            ..|...:.......|.:::...:|..| ..|:..||.:|.:.|:..|...: ..:.|.|...|||
Mouse   165 LKLVEKFLEEAKNHYQAEVFSVNFAES-EEAKKVINDFVEKGTQGKIAEAV-KKLDQDTVFALAN 227

  Fly   292 ALYFKAFWETDFIESATRPDNFYPNGEGTEPVMRVQMMATGGAYPYHEDHELGCKIIGLPYRGNL 356
            .:.||..|:..|....|....|:.:...|   ::|.||...|....|....|...::.:.|.||.
Mouse   228 YILFKGKWKKPFDPENTEEAEFHVDESTT---VKVPMMTLSGMLHVHHCSTLSSWVLLMDYAGNA 289

  Fly   357 STMYIIQPFKSSVRELMALQKRLTADKIESMISRMYRRAALVAFPKMHLTESVNLKTVMQRMGLG 421
            :.:::: |....::.   |::.|:.:.|...:....||.|.:.||::.::...||||:|..:|:.
Mouse   290 TAVFLL-PDDGKMQH---LEQTLSKELISKFLLNRRRRLAQIHFPRLSISGEYNLKTLMSPLGIT 350

  Fly   422 GIFSAVQN--DLSLIATNEATRTNALGGNSLQNLEAQRRAGTGGARSDLVVDDIVHKVDFTVNEQ 484
            .||:   |  |||.|     |..||                      .|.:...|||...|::|.
Mouse   351 RIFN---NGADLSGI-----TEENA----------------------PLKLSQAVHKAVLTIDET 385

  Fly   485 GTEAAASSVTYLKKSGPDVLFRGDTPFMVLVRHDPTKLVLFYGLINEP 532
            ||||||.:|..:.......:.|.|.||:.::..:.|:..:|.|.:.:|
Mouse   386 GTEAAAVTVLQMVPMSMPPILRFDHPFLFIIFEEHTQSPIFLGKVVDP 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Dc	NP_609172.1	SERPIN	111..527	CDD:238101	106/425 (25%)
Serpina1a	NP_001239498.1	SERPIN	76..433	CDD:214513	105/424 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D491891at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020