Protein Alignment Spn28Dc and SERPINB1

DIOPT Version :10

• Sequence 1: NP_609172.1
• Gene: Spn28Dc / 34091
• FlyBaseID: FBgn0031973
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_109591.1
• Gene: SERPINB1 / 1992
• HGNCID: 3311
• Length: 379
• Species: Homo sapiens
• Alignment Length: 409
• Identity: 109/409 - (26%)
• Similarity: 185/409 - (45%)
• Gaps: 68/409 - (16%)

  Fly   132 SPLSIVHSLALLLLGAKGRSYEELSTVFDIPDTSRLHEQFGLMLQDLQQPTREAISAGRPLTDWR 196
            ||.||..::|::.||.:|.:..:||..|.......:|.:|..:..|:.
Human    31 SPFSISSAMAMVFLGTRGNTAAQLSKTFHFNTVEEVHSRFQSLNADIN----------------- 78

  Fly   197 ASSAMRSNRRAQRPGAHEVHLANGLFTQTGYTLNPDYRRVIVEVYASDLQIQDFEGSPATARYNI 261
                       :|..::.:.|||.|:.:..|...|::.....:.|.:||...||:.:...||..|
Human    79 -----------KRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVDFQHASEDARKTI 132

  Fly   262 NAYVAQHTKNHIENIIASD-IPQTTRMILANALYFKAFWETDFIESATRPDNFYPNGEGTEPVMR 325
            |.:|...|:..|..::||. :...|:::|.||:|||..|:..|::.||....|..|.:..:.| :
Human   133 NQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRKTV-K 196

  Fly   326 VQMMATGGAYPYHEDHELGCKIIGLPYRGNLSTMYIIQP--FKSSVRELMALQKRLTADKIESMI 388
            :.......||.|.||  |.|:::.|||:|...:|.|:.|  .:.....|..::::||.:|:....
Human   197 MMYQKKKFAYGYIED--LKCRVLELPYQGEELSMVILLPDDIEDESTGLKKIEEQLTLEKLHEWT 259

  Fly   389 --SRMYRRAALVAFPKMHLTESVNLKTVMQRMGLGGIFSAVQNDLSLIATNEATRTNALGGNSLQ 451
              ..:......|:.|:..|.||..|.:.:.|:|:..:|::.:.|||
Human   260 KPENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNSSKADLS------------------- 305

  Fly   452 NLEAQRRAGTGGARSDLVVDDIVHKVDFTVNEQGTEAAASS---VTYLKKSGPDVLFRGDTPFMV 513
                    |..||| |:.:..||||....|||:||||||::   .|:.... |:..|..|.||:.
Human   306 --------GMSGAR-DIFISKIVHKSFVEVNEEGTEAAAATAGIATFCMLM-PEENFTADHPFLF 360

  Fly   514 LVRHDPTKLVLFYGLINEP 532
            .:||:.:..:||.|..:.|
Human   361 FIRHNSSGSILFLGRFSSP 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Dc	NP_609172.1	serpin28D-like_insects	111..532	CDD:381061	108/407 (27%)
SERPINB1	NP_109591.1	serpinB1_LEI	1..379	CDD:381028	108/407 (27%)
		CARD-binding motif (CBM). /evidence=ECO:0000269|PubMed:30692621	351..379		9/27 (33%)