DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn28Dc and Serpinb2

DIOPT Version :9

Sequence 1:	NP_609172.1	Gene:	Spn28Dc / 34091	FlyBaseID:	FBgn0031973	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001167641.1	Gene:	Serpinb2 / 18788	MGIID:	97609	Length:	415	Species:	Mus musculus

Alignment Length:	450	Identity:	115/450 - (25%)
Similarity:	196/450 - (43%)	Gaps:	65/450 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 IANSVLNFA-NILGQHLANGKTQ--IYSPLSIVHSLALLLLGAKGRSYEELSTVFDIPD------ 163
            :||::  || |:|.|...:..||  ..||.||..:||::||||.|.:.::::.|....:
Mouse     6 MANTM--FALNLLKQIEKSNSTQNIFISPWSISSTLAIVLLGAGGNTEQQMAKVLQFNEIGSYGI 68

  Fly   164 TSRLHE-----QFGLMLQDLQQPTREAI---SAGRPLTDWRASSAMRSNRRAQRPGAHEVHLANG 220
            |:|..|     .|...:|....|:  ||   .||..:..  |.|::.|.....: |.:.:..||.
Mouse    69 TTRNPENFSGCDFAQQIQKENYPS--AILQAQAGDKIHS--AFSSLSSTINTPQ-GDYLLESANK 128

  Fly   221 LFTQTGYTLNPDYRRVIVEVYASDLQIQDFEGSPATARYNINAYVAQHTKNHIENII-ASDIPQT 284
            ||.:.......:|.::..:.|:::.:..||......||..||::|...||..|.|:: ...:.:.
Mouse   129 LFGEKSARFKEEYIQLSKKYYSTEPEAVDFLECAEEAREKINSWVKTQTKGEIPNLLPEGSVDED 193

  Fly   285 TRMILANALYFKAFWETDFIESATRPDNFYPNGEGTEPVMRVQMMATGGAYPYHEDHELGCKIIG 349
            |:|:|.||:|||..|:|.|   ..:.:..||....:...:.||||............:|..:|:.
Mouse   194 TKMVLVNAVYFKGKWKTPF---EKKLNGLYPFRVNSHESIPVQMMFLHAKLNIGYIKDLKTQILE 255

  Fly   350 LPYRGNLSTMYII-QPFKSSVRELMALQKRLTADKIESMISR--MYRRAALVAFPKMHLTESVNL 411
            ||:.||:|.:.:: ...:.:...|..|:..:........||:  :.....:|..||..|.:|..|
Mouse   256 LPHTGNISMLLLLPDEIEDASTGLELLESEINFANFNKWISKDTLDEDDVVVYIPKFKLAQSYEL 320

  Fly   412 KTVMQRMGLGGIFSAVQNDLSLIATNEATRTNALGGNSLQNLEAQRRAGTGGARSDLVVDDIVHK 476
            |:::|.||:...|:..:.:.|              |.|              .|:||.:.::.|:
Mouse   321 KSILQSMGMEDAFNKGKANFS--------------GMS--------------ERNDLFLSEVFHQ 357

  Fly   477 VDFTVNEQGTEAAASSVTYLK----KSGPDVLFRGDTPFMVLVRHDPTKLVLFYGLINEP 532
            ....|.|:||.||..:...:.    ..||.  |..|.||:..:....|..:||.|..:.|
Mouse   358 ASVDVTEEGTVAAGGTGAVMTGRTGHGGPQ--FVADHPFLFFIMDKITHTILFVGRFSSP 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Dc	NP_609172.1	SERPIN	111..527	CDD:238101	111/440 (25%)
Serpinb2	NP_001167641.1	SERPIN	4..415	CDD:294093	114/448 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910