DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn28Dc and Serping1

DIOPT Version :9

Sequence 1:	NP_609172.1	Gene:	Spn28Dc / 34091	FlyBaseID:	FBgn0031973	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_033906.2	Gene:	Serping1 / 12258	MGIID:	894696	Length:	504	Species:	Mus musculus

Alignment Length:	528	Identity:	117/528 - (22%)
Similarity:	204/528 - (38%)	Gaps:	121/528 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 TPETMAYINGLMQRRHQMQQEAQQHIQAIPPA-VPLQSPGLVNGLGNQNDPALNRISGTSVKPSN 90
            |.:||..:         ..:...||.|  |.| :|..|||         .|.||..|..|. .|:
Mouse    74 TNDTMGKV---------ANESFSQHSQ--PAAQLPTDSPG---------QPPLNSSSQPST-ASD 117

  Fly    91 LPAAYS------NGYVDLATSDR------IANSVLNFANILGQHLANGK----TQIYSPLSIVHS 139
            ||...:      ......:.|||      ::.::.:|:..|....:..|    ...:||.||...
Mouse   118 LPTQATTEPFCPEPLAQCSDSDRDSSEAKLSEALTDFSVKLYHAFSATKMAKTNMAFSPFSIASL 182

  Fly   140 LALLLLGAKGRSYEELSTVFDIPDTSRLHEQFGLMLQDLQQPTREAISAGRPLTDWRASSAMRSN 204
            |..:||||...:...|.::...|      :.|..:.|.|:..:.:.:::        .|....|.
Mouse   183 LTQVLLGAGDSTKSNLESILSYP------KDFACVHQALKGFSSKGVTS--------VSQIFHSP 233

  Fly   205 RRAQRPGAHEVHLANGLFTQTGYTLNPDYRRVIVEVYASDLQIQDFEGSPATARYNINAYVAQHT 269
            ..|.|.  ..|:.:..|:..:...|.||        .|::|::             ||.:||::|
Mouse   234 DLAIRD--TYVNASQSLYGSSPRVLGPD--------SAANLEL-------------INTWVAENT 275

  Fly   270 KNHIENIIASDIPQTTRMILANALYFKAFWETDFIESATRPDNFYPNGEGTEPVMRVQMMATGGA 334
            .:.|..::.| :|..|.::|.||:|..|.|:..|.........||.|.     :::|.||:: ..
Mouse   276 NHKIRKLLDS-LPSDTCLVLLNAVYLSAKWKITFEPKKMMAPFFYKNS-----MIKVPMMSS-VK 333

  Fly   335 YP--YHEDHELGCKIIGLPYRGNLSTMYIIQPFKSSVRELMALQKRLTADKIESMISRMYRRAAL 397
            ||  ..:||.|..|:..|....|||.:.::..|..  .:|..::|.|.....::::.::.....|
Mouse   334 YPVAQFDDHTLKAKVGQLQLSHNLSFVIVVPVFPK--HQLKDVEKALNPTVFKAIMKKLELSKFL 396

  Fly   398 ---VAFPKMHLTESVNLKTVMQRMGLGGIFSAVQNDLSLIATNEATRTNALGGNSLQNLEAQRRA 459
               :..|.:.:..|.::.:||:::.    |.....||:|....|
Mouse   397 PTYLTMPHIKVKSSQDMLSVMEKLE----FFDFTYDLNLCGLTE--------------------- 436

  Fly   460 GTGGARSDLVVDDIVHKVDFTVNEQGTEAAASSVTYLKKSGPDVLFRGDTPFMVLVRHDPTKLVL 524
                 ..||.|..:.|:....:.|.|.||||:|.....:|.|  :|....||:.|:.....:..:
Mouse   437 -----DPDLQVSAMKHETVLELTESGVEAAAASAISFGRSLP--IFEVQRPFLFLLWDQQHRFPV 494

  Fly   525 FYGLINEP 532
            |.|.:.:|
Mouse   495 FMGRVYDP 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn28Dc	NP_609172.1	SERPIN	111..527	CDD:238101	92/424 (22%)
Serping1	NP_033906.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..67
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..141		19/67 (28%)
		serpinG1_C1-INH	141..500	CDD:381006	93/436 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100