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Protein Alignment Wwox and CBR1

DIOPT Version :9

Sequence 1:	NP_001285735.1	Gene:	Wwox / 34090	FlyBaseID:	FBgn0031972	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001748.1	Gene:	CBR1 / 873	HGNCID:	1548	Length:	277	Species:	Homo sapiens

Alignment Length:	279	Identity:	58/279 - (20%)
Similarity:	112/279 - (40%)	Gaps:	75/279 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 ALITGANCGIGYETARSLAH-HGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAALDLSSLR 187
            ||:||.|.|||....|.|.. ...:::...|:.:..:||::::..|..:.    ||..||:..|:
Human     8 ALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSP----RFHQLDIDDLQ 68

  Fly   188 SVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLTLQ--LETLF---- 246
            |::...:.:::....:|.|:.|||:              .|:|:..:.|::..:  ::|.|
Human    69 SIRALRDFLRKEYGGLDVLVNNAGI--------------AFKVADPTPFHIQAEVTMKTNFFGTR 119

  Fly   247 DYKTRIIVLSSESHRFANLP--VENLAVHHLSPP-PEKY-------------------------- 282
            |..|.::.|.....|..|:.  :...|:...||. .:|:
Human   120 DVCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGVH 184

  Fly   283 ----WSMMAYNNAKL----CNVLFAQELAQRWKQRGISVFSLHPGNMVSSDLSRNYWFYRLLFAI 339
                |...||...|:    .:.:.|::|:::.|...|.:.:..|| .|.:|::.
Human   185 QKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPG-WVRTDMAG----------- 237

  Fly   340 VRPFTKSLQQAAATSIYCA 358
             ...|||.::.|.|.:|.|
Human   238 -PKATKSPEEGAETPVYLA 255

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.