Protein Alignment Wwox and PBR1

DIOPT Version :10

• Sequence 1: NP_609171.1
• Gene: Wwox / 34090
• FlyBaseID: FBgn0031972
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: NP_014218.2
• Gene: PBR1 / 855540
• SGDID: S000005125
• Length: 407
• Species: Saccharomyces cerevisiae
• Alignment Length: 342
• Identity: 76/342 - (22%)
• Similarity: 134/342 - (39%)
• Gaps: 68/342 - (19%)

  Fly   117 KDLHGRTALITGANC-GIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFA- 179
            :.|||:..|:|||.. |:|...|..:|..|.::|..  .|...|...|...:.|...::...|.
Yeast    49 RKLHGKVYLVTGATSQGMGTSVAYKMAELGAQLIIL--TREVDEWVTEWCEELREKTKNELIFVE 111

  Fly   180 ALDLSSLRSVQRFVEE--IKQSVSHIDYLILNAG--------VFALPYTR-TVDGLETTFQVSHL 233
            ..|||:|..:::|...  .......:|.:|:.:|        ..:||..| :.||||.....:::
Yeast   112 KCDLSNLWEIRKFATSWLDNSPPRRLDGVIVMSGDMEPWGIPKISLPQRRSSKDGLELQIATNYV 176

  Fly   234 SHFYLTLQLETLF-----DYKTRIIVLSSESHRFANLPVENLAVHHLSPPPEKYWSMMAYNNA-- 291
            :.|:|...|:..|     |...|||:.:.......::.:|           :..|....|.:|
Yeast   177 AIFHLLNLLQPSFKAQPPDRDVRIILATCWLQVVGDINIE-----------DPLWQNAKYKSALK 230

  Fly   292 -----KLCNVLFAQELAQRWKQ--------------RGISVFSLHPGNMVSSDLSR--------- 328
                 ||...|...||.:|..:              :.:::..:.||.|.|:.|.|
Yeast   231 FFASSKLQLGLSMMELQRRLTEDIKNQKTNGAERTGKNVTITMVQPGTMRSNSLRRVISNGSVVL 295

  Fly   329 -NYWFYRLLFAIVRPFTKSLQQAAATSIYCATANELTGLS-----GLYFNNCFFCE-PSKLSKSA 386
             ...:..||:.|:..||||.::...:.:|.....||..::     ..|.::|...: ..|.....
Yeast   296 LIILYCILLYPILWLFTKSGRRGDQSFLYALMTPELEEVNLKDTKVKYISDCSIVKFARKEFDDE 360

  Fly   387 ALQQQLWKLSENLIAEL 403
            .||::|:..:|..|.:|
Yeast   361 ELQKKLFDNTERDILQL 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_609171.1	WW	13..43	CDD:197736
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	73/335 (22%)
PBR1	NP_014218.2	retinol-DH_like_SDR_c_like	53..367	CDD:212492	70/326 (21%)