DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wwox and Tic32-IVa

DIOPT Version :9

Sequence 1:	NP_001285735.1	Gene:	Wwox / 34090	FlyBaseID:	FBgn0031972	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_849428.1	Gene:	Tic32-IVa / 828442	AraportID:	AT4G23430	Length:	322	Species:	Arabidopsis thaliana

Alignment Length:	307	Identity:	117/307 - (38%)
Similarity:	172/307 - (56%)	Gaps:	17/307 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 FDSCSTALQVLHGKDLHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQE 168
            |.|.|||.:|.||.|..|.||::|||:.|||.||||.|:..|..::.|.||..|.....|.|.::
plant    12 FSSRSTAEEVTHGVDGTGLTAIVTGASSGIGVETARVLSLRGVHVVMAVRNTDSGAKVKEDIVKQ 76

  Fly   169 RPAARSRCRFAALDLSSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHL 233
            .|.|  :.....|||||::||::|..|.|.:...::.||.|||:.|.|:..:.|.:|..|..:||
plant    77 VPGA--KLDVMELDLSSMQSVRKFASEYKSTGLPLNLLINNAGIMACPFMLSKDNIELQFATNHL 139

  Fly   234 SHFYLT-LQLETL------FDYKTRIIVLSSESHRFANLPVENLAVHHLSPPPEKYWSMMAYNNA 291
            .||.|| |.|:|:      ...:.||:.||||:||| :.| |.:....:: ....|.||.||..:
plant   140 GHFLLTKLLLDTMKSTSRESKREGRIVNLSSEAHRF-SYP-EGVRFDKIN-DKSSYSSMRAYGQS 201

  Fly   292 KLCNVLFAQELAQRWKQRGISVF--SLHPGNMVSSDLSR--NYWFYRLLFAIVRPFTKSLQQAAA 352
            ||||||.|.||.::.|:.|:::.  ||||| .:.::|.|  |.:....:.|:.:...||:.|.||
plant   202 KLCNVLHANELTKQLKEDGVNITANSLHPG-AIMTNLGRYFNPYLAVAVGAVAKYILKSVPQGAA 265

  Fly   353 TSIYCATANELTGLSGLYFNNCFFCEPSKLSKSAALQQQLWKLSENL 399
            |:.|.|...::.|:||.||.:....:|..|.|...|.:::|..|..|
plant   266 TTCYVALNPQVAGVSGEYFQDSNIAKPLPLVKDTELAKKVWDFSTKL 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_001285735.1	WW	13..43	CDD:197736
		WW	54..86	CDD:197736
		PRK06196	104..402	CDD:235736	117/307 (38%)
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	108/290 (37%)
Tic32-IVa	NP_849428.1	retinol-DH_like_SDR_c_like	29..306	CDD:212492	105/282 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	76	1.000	Domainoid score	I3143
eggNOG	1	0.900	-	-		E2759_KOG1208
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	1	1.100	-	-	O	PTHR24320
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.810