DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Wwox and Wwox

DIOPT Version :9

Sequence 1:NP_001285735.1 Gene:Wwox / 34090 FlyBaseID:FBgn0031972 Length:409 Species:Drosophila melanogaster
Sequence 2:NP_062519.2 Gene:Wwox / 80707 MGIID:1931237 Length:414 Species:Mus musculus


Alignment Length:406 Identity:207/406 - (50%)
Similarity:271/406 - (66%) Gaps:14/406 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 LPDTDSEDELPPGWEERATDDGTVCYVNQQGKTSQWTHPRTGRSKRITGELPLGWEKYYDEQGKR 68
            |.|||||||||||||||.|.||.|.|.|...:.:||.||:||:.||:.|:||.|||:..||.|:.
Mouse     9 LDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQV 73

  Fly    69 FM--FLNKETQQRTNVDPRLAFAVEE-PTQNVAQVRQRFDSCSTALQVLHGKDLHGRTALITGAN 130
            |.  .:||.|   |.:||||||.|:: ||:  ...|||:|..:||:::|.|:|..|:..|:||||
Mouse    74 FFVDHINKRT---TYLDPRLAFTVDDNPTK--PTTRQRYDGSTTAMEILQGRDFTGKVVLVTGAN 133

  Fly   131 CGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAALDLSSLRSVQRFVEE 195
            .|||:|||:|.|.||..:|.||||.|.|..|:.||.:|...|:...  ..|||:.|||||.|.|.
Mouse   134 SGIGFETAKSFALHGAHVILACRNLSRASEAVSRILEEWHKAKVEA--MTLDLAVLRSVQHFAEA 196

  Fly   196 IKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLTLQLETLF--DYKTRIIVLSSE 258
            .|.....:..|:.|||.||||:..|.|||||||||:||.||||...|:.:.  ....|:||:|||
Mouse   197 FKAKNVSLHVLVCNAGTFALPWGLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSSPARVIVVSSE 261

  Fly   259 SHRFANLPVEN--LAVHHLSPPPEKYWSMMAYNNAKLCNVLFAQELAQRWKQRGISVFSLHPGNM 321
            ||||.::...:  |.:..||||...||:|:|||.:||||:||:.||.:|...||::..::|||||
Mouse   262 SHRFTDINDSSGKLDLSRLSPPRSDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNM 326

  Fly   322 VSSDLSRNYWFYRLLFAIVRPFTKSLQQAAATSIYCATANELTGLSGLYFNNCFFCEPSKLSKSA 386
            :.|.:.||.|.|:|||.:.||||||:||.|||::|||.|.||.||.|:|||||..|.||:.::|.
Mouse   327 MYSAIHRNSWVYKLLFTLARPFTKSMQQGAATTVYCAVAPELEGLGGMYFNNCCRCLPSEEAQSE 391

  Fly   387 ALQQQLWKLSENLIAE 402
            ...:.||:|||.||.:
Mouse   392 ETARALWELSERLIQD 407

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
WwoxNP_001285735.1 WW 13..43 CDD:197736 17/29 (59%)
WW 54..86 CDD:197736 15/33 (45%)
PRK06196 104..402 CDD:235736 151/301 (50%)
human_WWOX_like_SDR_c-like 121..402 CDD:187669 145/284 (51%)
WwoxNP_062519.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24 13/14 (93%)
WW 19..47 CDD:238122 15/27 (56%)
Nuclear localization signal 50..55 2/4 (50%)
WW 60..90 CDD:238122 13/31 (42%)
PRK06196 107..404 CDD:235736 151/300 (50%)
human_WWOX_like_SDR_c-like 124..407 CDD:187669 145/286 (51%)
Interaction with MAPT. /evidence=ECO:0000269|PubMed:15126504 125..414 145/287 (51%)
Mediates targeting to the mitochondria 209..273 35/65 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167848760
Domainoid 1 1.000 159 1.000 Domainoid score I4086
eggNOG 1 0.900 - - E2759_KOG1208
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H56334
Inparanoid 1 1.050 403 1.000 Inparanoid score I1906
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48603
OrthoDB 1 1.010 - - D1413827at2759
OrthoFinder 1 1.000 - - FOG0000061
OrthoInspector 1 1.000 - - oto94883
orthoMCL 1 0.900 - - OOG6_100091
Panther 1 1.100 - - LDO PTHR24320
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R408
SonicParanoid 1 1.000 - - X72
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1716.800

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