DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wwox and DHRS12

DIOPT Version :9

Sequence 1:	NP_001285735.1	Gene:	Wwox / 34090	FlyBaseID:	FBgn0031972	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001364858.1	Gene:	DHRS12 / 79758	HGNCID:	25832	Length:	320	Species:	Homo sapiens

Alignment Length:	203	Identity:	63/203 - (31%)
Similarity:	90/203 - (44%)	Gaps:	16/203 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 GRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAALDLSS 185
            ||..|:||.|.|||..||..:|..|..:...||:::.||.|...|.:|  :.........:|||.
Human    40 GRVFLVTGGNSGIGKATALEIAKRGGTVHLVCRDQAPAEDARGEIIRE--SGNQNIFLHIVDLSD 102

  Fly   186 LRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLTLQLETLF--DY 248
            .:.:.:|||..||. ..:..||.|||........|.||||..|..:.|..:.||..|..:.  ::
Human   103 PKQIWKFVENFKQE-HKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLEKEH 166

  Fly   249 KTRIIVLSSESHRFANLPVENLAVHHLSPPPEKYWSMMAYNNAKLCNVLFAQELAQRWKQ--RGI 311
            ..|:|.:||     ..:.|:.|..:.|......:...|.|...|...|:    |.:||.|  ..|
Human   167 DPRVITVSS-----GGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVV----LTERWAQGHPAI 222

  Fly   312 SVFSLHPG 319
            ...|:|||
Human   223 HFSSMHPG 230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_001285735.1	WW	13..43	CDD:197736
		WW	54..86	CDD:197736
		PRK06196	104..402	CDD:235736	63/203 (31%)
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	63/203 (31%)
DHRS12	NP_001364858.1	NADB_Rossmann	40..>235	CDD:419666	63/203 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810