DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wwox and hsd17b7

DIOPT Version :9

Sequence 1:	NP_001285735.1	Gene:	Wwox / 34090	FlyBaseID:	FBgn0031972	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001070796.1	Gene:	hsd17b7 / 768185	ZFINID:	ZDB-GENE-061013-378	Length:	340	Species:	Danio rerio

Alignment Length:	345	Identity:	88/345 - (25%)
Similarity:	141/345 - (40%)	Gaps:	86/345 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 RTALITGANCGIGYETARSLAHHGC--EIIFACRNRSSAEAAIERIAQERPAARSRCRFAALDLS 184
            :..|:||||.|||......|.:...  |:..||||...||||.:.:....|.|  |.....||:.
Zfish     3 KVVLVTGANSGIGLALCERLLNEDAQIELCLACRNMQRAEAARKALLVSHPQA--RVSLLHLDVG 65

  Fly   185 SLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVD--------------------------- 222
            ::.||.:..||.|:..:.:|||.||||:...|   |||
Zfish    66 NMHSVVKGAEEFKKKFNRLDYLYLNAGIMPNP---TVDHVAFYRGLFSRNAIKMLTTGEGILTQE 127

  Fly   223 ------GLETTFQVSHLSHFYLTLQLETLF---DYKTRIIVLSSESHRFANLPVENLAVHHLSPP 278
                  ||:..|..:...||.|..:||.|.   ::.:.:|..||.:.:.::..:|:  |.|.:.|
Zfish   128 DKVTPIGLQEVFATNLFGHFLLVKELEPLLCQTEHNSLVIWTSSSNAQRSSFNLED--VQHKNGP 190

  Fly   279 PEKYWSMMAYNNAKLCNVLFAQELAQRWKQRGISVFSLHPG----NMVSSDLSRNYW--FYRLLF 337
                   :.|:::|..:.|.:..|.:.:..:|:....:.||    |:....|...:|  ...:||
Zfish   191 -------LPYSSSKYASDLLSLALNRHYNSQGMFSSVICPGLVMTNLTYGILPSLFWTIIMPILF 248

  Fly   338 AIVRPFTKSLQQA---AATSIY------------CATANELTGLSGLYFNNCFFCEPSKLSKSAA 387
             ::|.||.|...:   .|.::|            .|..:.||  |||..|   :..|||:....
Zfish   249 -LIRIFTNSFTLSPYNGAEALYWLFKQKPESLDPMAKYHSLT--SGLGNN---YTRPSKMDLDE- 306

  Fly   388 LQQQLWKLSENLIAELVEQE 407
                  .:||....:|:|.|
Zfish   307 ------NMSEAFYVKLLELE 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_001285735.1	WW	13..43	CDD:197736
		WW	54..86	CDD:197736
		PRK06196	104..402	CDD:235736	85/338 (25%)
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	85/338 (25%)
hsd17b7	NP_001070796.1	3KS_SDR_c	2..280	CDD:187645	73/291 (25%)
hsd17b7	NP_001070796.1	adh_short	3..231	CDD:278532	63/241 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1413827at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R408
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950