DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wwox and RDH14

DIOPT Version :9

Sequence 1:	NP_001285735.1	Gene:	Wwox / 34090	FlyBaseID:	FBgn0031972	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_065956.1	Gene:	RDH14 / 57665	HGNCID:	19979	Length:	336	Species:	Homo sapiens

Alignment Length:	304	Identity:	113/304 - (37%)
Similarity:	169/304 - (55%)	Gaps:	28/304 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 LHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQE-RPAAR--------- 173
            :||:|.||||||.|:|..||..|...|..:|..||:|:.||.|..::.:| |.||.
Human    41 MHGKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGVSG 105

  Fly   174 -SRCRFAALDLSSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFY 237
             .......|||:|||||:.|.:|:.|....:|.||.|||:|..||.:|.||.|..|.|:||.||.
Human   106 VGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFGVNHLGHFL 170

  Fly   238 LTLQLETLF--DYKTRIIVLSSESHRFANLPVENLAVHHLSPPPEKYWSMMAYNNAKLCNVLFAQ 300
            ||..|..|.  ...:||:|:||:.:::.::..::|      ...:.|.....|:.:||.|:||.:
Human   171 LTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDL------NSEQSYNKSFCYSRSKLANILFTR 229

  Fly   301 ELAQRWKQRGISVFSLHPGNMVSSDLSRNYWFYRL---LFAIVR-PFTKSLQQAAATSIYCATAN 361
            |||:|.:...::|..|||| :|.::|.|:.....|   ||.:|. .|.|:..:.|.||||.|::.
Human   230 ELARRLEGTNVTVNVLHPG-IVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLASSP 293

  Fly   362 ELTGLSGLYFNNCFFCE--PSKLSKSAALQQQLWKLSENLIAEL 403
            |:.|:||.||.:|...|  |..:.:|.|  ::||.:||.::..|
Human   294 EVEGVSGRYFGDCKEEELLPKAMDESVA--RKLWDISEVMVGLL 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_001285735.1	WW	13..43	CDD:197736
		WW	54..86	CDD:197736
		PRK06196	104..402	CDD:235736	112/301 (37%)
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	111/299 (37%)
RDH14	NP_065956.1	retinol-DH_like_SDR_c	43..328	CDD:212495	109/293 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.710