Protein Alignment Wwox and RDH14

DIOPT Version :10

• Sequence 1: NP_609171.1
• Gene: Wwox / 34090
• FlyBaseID: FBgn0031972
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: NP_065956.1
• Gene: RDH14 / 57665
• HGNCID: 19979
• Length: 336
• Species: Homo sapiens
• Alignment Length: 304
• Identity: 113/304 - (37%)
• Similarity: 169/304 - (55%)
• Gaps: 28/304 - (9%)

  Fly   119 LHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQE-RPAAR--------- 173
            :||:|.||||||.|:|..||..|...|..:|..||:|:.||.|..::.:| |.||.
Human    41 MHGKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGVSG 105

  Fly   174 -SRCRFAALDLSSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFY 237
             .......|||:|||||:.|.:|:.|....:|.||.|||:|..||.:|.||.|..|.|:||.||.
Human   106 VGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFGVNHLGHFL 170

  Fly   238 LTLQLETLF--DYKTRIIVLSSESHRFANLPVENLAVHHLSPPPEKYWSMMAYNNAKLCNVLFAQ 300
            ||..|..|.  ...:||:|:||:.:::.::..::|      ...:.|.....|:.:||.|:||.:
Human   171 LTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDL------NSEQSYNKSFCYSRSKLANILFTR 229

  Fly   301 ELAQRWKQRGISVFSLHPGNMVSSDLSRNYWFYRL---LFAIVR-PFTKSLQQAAATSIYCATAN 361
            |||:|.:...::|..|||| :|.::|.|:.....|   ||.:|. .|.|:..:.|.||||.|::.
Human   230 ELARRLEGTNVTVNVLHPG-IVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLASSP 293

  Fly   362 ELTGLSGLYFNNCFFCE--PSKLSKSAALQQQLWKLSENLIAEL 403
            |:.|:||.||.:|...|  |..:.:|.|  ::||.:||.::..|
Human   294 EVEGVSGRYFGDCKEEELLPKAMDESVA--RKLWDISEVMVGLL 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_609171.1	WW	13..43	CDD:197736
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	111/299 (37%)
RDH14	NP_065956.1	retinol-DH_like_SDR_c	43..328	CDD:212495	109/293 (37%)