DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wwox and WWOX

DIOPT Version :9

Sequence 1:	NP_001285735.1	Gene:	Wwox / 34090	FlyBaseID:	FBgn0031972	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_057457.1	Gene:	WWOX / 51741	HGNCID:	12799	Length:	414	Species:	Homo sapiens

Alignment Length:	406	Identity:	202/406 - (49%)
Similarity:	267/406 - (65%)	Gaps:	14/406 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPDTDSEDELPPGWEERATDDGTVCYVNQQGKTSQWTHPRTGRSKRITGELPLGWEKYYDEQGKR 68
            |.|||||||||||||||.|.||.|.|.|...:.:||.||:||:.||:.|:||.|||:..||.|:.
Human     9 LDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQV 73

  Fly    69 FM--FLNKETQQRTNVDPRLAFAVEE-PTQNVAQVRQRFDSCSTALQVLHGKDLHGRTALITGAN 130
            |.  .:||.|   |.:||||||.|:: ||:  ...|||:|..:||:::|.|:|..|:..::||||
Human    74 FFVDHINKRT---TYLDPRLAFTVDDNPTK--PTTRQRYDGSTTAMEILQGRDFTGKVVVVTGAN 133

  Fly   131 CGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAALDLSSLRSVQRFVEE 195
            .|||:|||:|.|.||..:|.||||.:.|..|:.||.:|...|:...  ..|||:.|||||.|.|.
Human   134 SGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVEA--MTLDLALLRSVQHFAEA 196

  Fly   196 IKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLTLQLETLF--DYKTRIIVLSSE 258
            .|.....:..|:.||..||||::.|.|||||||||:||.||||...|:.:.  ....|:||:|||
Human   197 FKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSE 261

  Fly   259 SHRFANL--PVENLAVHHLSPPPEKYWSMMAYNNAKLCNVLFAQELAQRWKQRGISVFSLHPGNM 321
            ||||.::  .:..|....|||....||:|:|||.:||||:||:.||.:|...||::..::|||||
Human   262 SHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNM 326

  Fly   322 VSSDLSRNYWFYRLLFAIVRPFTKSLQQAAATSIYCATANELTGLSGLYFNNCFFCEPSKLSKSA 386
            :.|::.|::|.|.|||.:.||||||:||.|||::|||...||.||.|:|||||..|.||..::|.
Human   327 MYSNIHRSWWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSE 391

  Fly   387 ALQQQLWKLSENLIAE 402
            ...:.||.|||.||.|
Human   392 ETARTLWALSERLIQE 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_001285735.1	WW	13..43	CDD:197736	17/29 (59%)
		WW	54..86	CDD:197736	15/33 (45%)
		PRK06196	104..402	CDD:235736	145/301 (48%)
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	139/284 (49%)
WWOX	NP_057457.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		12/13 (92%)
		WW	19..47	CDD:238122	15/27 (56%)
		Nuclear localization signal. /evidence=ECO:0000250	50..55		2/4 (50%)
		WW	60..90	CDD:238122	14/32 (44%)
		human_WWOX_like_SDR_c-like	124..407	CDD:187669	139/284 (49%)
		Interaction with MAPT. /evidence=ECO:0000250	125..414		139/285 (49%)
		Mediates targeting to the mitochondria. /evidence=ECO:0000250	209..273		33/63 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158364
Domainoid	1	1.000	155	1.000	Domainoid score	I4230
eggNOG	1	0.900	-	-		E2759_KOG1208
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56334
Inparanoid	1	1.050	394	1.000	Inparanoid score	I1982
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48603
OrthoDB	1	1.010	-	-		D1413827at2759
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	1	1.000	-	-		oto91305
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	1	1.100	-	-	LDO	PTHR24320
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R408
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800