DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wwox and Rdh14

DIOPT Version :9

Sequence 1:	NP_001285735.1	Gene:	Wwox / 34090	FlyBaseID:	FBgn0031972	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001102746.1	Gene:	Rdh14 / 500629	RGDID:	1565196	Length:	334	Species:	Rattus norvegicus

Alignment Length:	301	Identity:	114/301 - (37%)
Similarity:	168/301 - (55%)	Gaps:	25/301 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 LHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQE--------RPAARSR 175
            :||:|.||||||.|:|..||..|...|..:|..||:|:.||.|..::.||        ..|...:
  Rat    42 MHGKTVLITGANSGLGRATAGELLRLGARVIMGCRDRARAEEAAGQLRQELGQAGGLGPDATDGQ 106

  Fly   176 CRFAALDLSSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLTL 240
            .....|||:|||||:.|.:|:.|....:|.||.|||||..|||:|.||.|..|.|:||.||.||.
  Rat   107 LVVKELDLASLRSVRAFCQELLQEEPRLDVLINNAGVFQCPYTKTEDGFEMQFGVNHLGHFLLTN 171

  Fly   241 QLETLF--DYKTRIIVLSSESHRFANLPVENLAVHHLSPPPEKYWSMMAYNNAKLCNVLFAQELA 303
            .|..|.  ...:||:|:||:.:::.::..|:|      ...:.|.....|:.:||.|:||.:|||
  Rat   172 LLLGLLKSSAPSRIVVVSSKLYKYGDINFEDL------NSEQSYNKSFCYSRSKLANILFTRELA 230

  Fly   304 QRWKQRGISVFSLHPGNMVSSDLSRNY---WFYRLLFAIVR-PFTKSLQQAAATSIYCATANELT 364
            .|.:...::|..|||| :|.::|.|:.   ...|.||.:|. .|.|:..:.|.||||.|::.::.
  Rat   231 HRLEGTNVTVNVLHPG-IVRTNLGRHIHIPLLARPLFNLVSWAFFKTPLEGAQTSIYLASSPDVE 294

  Fly   365 GLSGLYFNNCFFCE--PSKLSKSAALQQQLWKLSENLIAEL 403
            |:||.||.:|...|  |..:.:|.|  ::||.:||.::..|
  Rat   295 GVSGRYFGDCKEEELLPKAMDESVA--RKLWDISEVMVGIL 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_001285735.1	WW	13..43	CDD:197736
		WW	54..86	CDD:197736
		PRK06196	104..402	CDD:235736	113/298 (38%)
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	112/296 (38%)
Rdh14	NP_001102746.1	PRK06197	43..332	CDD:235737	113/297 (38%)
Rdh14	NP_001102746.1	NADB_Rossmann	44..326	CDD:304358	110/290 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.710