DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wwox and CG7675

DIOPT Version :9

Sequence 1:	NP_001285735.1	Gene:	Wwox / 34090	FlyBaseID:	FBgn0031972	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001287390.1	Gene:	CG7675 / 42211	FlyBaseID:	FBgn0038610	Length:	336	Species:	Drosophila melanogaster

Alignment Length:	328	Identity:	113/328 - (34%)
Similarity:	179/328 - (54%)	Gaps:	32/328 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 NVAQVRQRFDSCSTALQVLHGK-----DLHGRTALITGANCGIGYETARSLAHHGCEIIFACRNR 155
            :||.:.....|....|::..|:     .:.|:|.:|||||.|||.|||:.||..|..||.||||.
  Fly    22 SVAAIVATLMSIRFYLRITAGRCFTETKMEGKTVIITGANSGIGKETAKDLAGRGARIIMACRNL 86

  Fly   156 SSAEAAIERIAQERPAARSRCRFAALDLSSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPY--T 218
            .:|.|..:.|.:|  ...::.....|||.|.:||:.|..:|.::...||.||.|||: ||.:  .
  Fly    87 ETANAVKDEIVKE--TKNNKILVKKLDLGSQKSVREFAADIVKTEPKIDVLIHNAGM-ALAFRGQ 148

  Fly   219 RTVDGLETTFQVSHLSHFYLT-LQLETL-FDYKTRIIVLSSESHRFANLPVENLA-VHHLSPPPE 280
            .:.||:|.|...:|...|.|| |.::.| .....||::::||.:|.:::   ||| ::.:...|.
  Fly   149 TSEDGVELTMATNHYGPFLLTHLLIDVLKKSAPARIVIVASELYRLSSV---NLAKLNPIGTFPA 210

  Fly   281 KYWSMMAYNNAKLCNVLFAQELAQRWKQRGISVFSLHPGNMVSSDLSRNYWFYRLL--FAIVRPF 343
            .|    .|..:|..|:.||:|||:|.:...::|..|||| |:.|.:.||..|...|  .||.:.|
  Fly   211 AY----LYYVSKFANIYFARELAKRLEGTKVTVNFLHPG-MIDSGIWRNVPFPLNLPMMAITKGF 270

  Fly   344 TKSLQQAAATSIYCATANELTGLSGLYFNNCFFCEPSKLSKSAALQQQ----LWKLSENLIAELV 404
            .|:.:..|.|:||.||:||:..:||.||.:   |:.:.|: :|||.::    :|:.|..:: :|.
  Fly   271 FKTTKAGAQTTIYLATSNEVANVSGKYFMD---CKEATLN-AAALDEEKGLKIWEESVKIV-KLT 330

  Fly   405 EQE 407
            .|:
  Fly   331 PQD 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_001285735.1	WW	13..43	CDD:197736
		WW	54..86	CDD:197736
		PRK06196	104..402	CDD:235736	109/313 (35%)
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	106/291 (36%)
CG7675	NP_001287390.1	PRK06196	52..327	CDD:235736	106/289 (37%)
CG7675	NP_001287390.1	retinol-DH_like_SDR_c_like	52..320	CDD:212492	104/282 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1208
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	113	1.000	Inparanoid score	I1353
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	1	1.100	-	-	P	PTHR24320
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X72
	7	6.860