DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wwox and dhrs13l1

DIOPT Version :9

Sequence 1:	NP_001285735.1	Gene:	Wwox / 34090	FlyBaseID:	FBgn0031972	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_991211.1	Gene:	dhrs13l1 / 402945	ZFINID:	ZDB-GENE-040426-1907	Length:	318	Species:	Danio rerio

Alignment Length:	290	Identity:	98/290 - (33%)
Similarity:	157/290 - (54%)	Gaps:	17/290 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 LHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAALDL 183
            |:|:|.::||.|.|||..||.:||..|..:|.|||::...|.|.:.|..|  :......|..|||
Zfish    33 LYGKTVIVTGGNTGIGKATATALAVRGARVILACRSKQKGEEAAKEIRTE--SGNDDVIFMQLDL 95

  Fly   184 SSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLT-LQLETLFD 247
            :|.:|::.|.|...::...:|.||.|||:.|.  .||.||:.....|:|:..|.|| |.||.|.:
Zfish    96 ASQKSIRSFAETFLKTEPRLDLLINNAGLAAA--GRTEDGIGMILGVNHIGPFLLTNLLLERLKE 158

  Fly   248 -YKTRIIVLSSESHRFANLPVENLAVHHL----SPPPEKYWSMMAYNNAKLCNVLFAQELAQRWK 307
             ..:|::.:||..|....:..:.:..|..    |...:.:   .||.::|||||||..|||:|.:
Zfish   159 CAPSRVVNVSSCGHDLGTIDFDCINTHKKLGLGSSDGDLF---RAYTHSKLCNVLFTHELAKRLE 220

  Fly   308 QRGISVFSLHPGNMVSSDLSRNY--WFYRLLFAIV-RPFTKSLQQAAATSIYCATANELTGLSGL 369
            ...::.:|||||: |.|:|.|:.  |..|:|..:| :.|.......|.|::||:..:.:..|||.
Zfish   221 GTNVTCYSLHPGS-VRSELGRDITEWHARVLLTVVSKFFATDPVSGAQTTLYCSLQDGIEHLSGR 284

  Fly   370 YFNNCFFCEPSKLSKSAALQQQLWKLSENL 399
            ||::|...:....::...:.::||::||.|
Zfish   285 YFSDCQLVQVKAEARDDGVAKKLWEVSEKL 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_001285735.1	WW	13..43	CDD:197736
		WW	54..86	CDD:197736
		PRK06196	104..402	CDD:235736	98/290 (34%)
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	97/288 (34%)
dhrs13l1	NP_991211.1	PRK06197	35..316	CDD:235737	97/288 (34%)
dhrs13l1	NP_991211.1	NADB_Rossmann	35..311	CDD:304358	94/283 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810