DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wwox and dhrs13

DIOPT Version :9

Sequence 1:	NP_001285735.1	Gene:	Wwox / 34090	FlyBaseID:	FBgn0031972	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_989311.1	Gene:	dhrs13 / 394935	XenbaseID:	XB-GENE-1006231	Length:	314	Species:	Xenopus tropicalis

Alignment Length:	285	Identity:	99/285 - (34%)
Similarity:	155/285 - (54%)	Gaps:	13/285 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 LHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAALDL 183
            |.|:|.::||||.|||..||..:|..|..:|.|||.:.:.|||...|  .:.:..::..|..|||
Frog    34 LKGKTVIVTGANVGIGKMTALDMAKRGARVILACRVKETGEAAAYDI--RKLSGNNQVVFMKLDL 96

  Fly   184 SSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLTLQLETLFDY 248
            :||.||:.|......|...:|.||.|||:..  :.:|.:|....|.|:||.||.||..|......
Frog    97 ASLESVRSFCRAFLSSEPRLDILINNAGLSG--FGKTAEGYNIVFGVNHLGHFLLTSLLLDRLKQ 159

  Fly   249 KT--RIIVLSSESHRFANLPVENLAVHHLSPPPEKYWSMMAYNNAKLCNVLFAQELAQRWKQRGI 311
            .|  ||:||:|.:|.:..:....::|    |......::.:|.::||||||||:|||.|.:...:
Frog   160 STPSRIVVLASYAHEWGKIDFNKISV----PSEHVKDTLQSYCDSKLCNVLFARELANRLQGTSV 220

  Fly   312 SVFSLHPGNMVSSDLSRNY--WFYRLLFAIVRPFTKSLQQAAATSIYCATANELTGLSGLYFNNC 374
            :.:|:|||. |.::|:|:.  |...|:..:...|.::....|.||||||....:...||.||:||
Frog   221 TCYSVHPGT-VHTNLARSLPSWIKVLIEPVSWLFLRTPMNGAQTSIYCAVQEGIEMYSGRYFDNC 284

  Fly   375 FFCEPSKLSKSAALQQQLWKLSENL 399
            ...:....::..|:.::||::||.:
Frog   285 QVRQVKPHARDDAVAKKLWEVSERM 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_001285735.1	WW	13..43	CDD:197736
		WW	54..86	CDD:197736
		PRK06196	104..402	CDD:235736	99/285 (35%)
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	98/283 (35%)
dhrs13	NP_989311.1	NADB_Rossmann	36..306	CDD:389744	96/278 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910