DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wwox and F32A5.8

DIOPT Version :9

Sequence 1:	NP_001285735.1	Gene:	Wwox / 34090	FlyBaseID:	FBgn0031972	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_495516.2	Gene:	F32A5.8 / 353400	WormBaseID:	WBGene00017971	Length:	257	Species:	Caenorhabditis elegans

Alignment Length:	253	Identity:	85/253 - (33%)
Similarity:	128/253 - (50%)	Gaps:	16/253 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 VDPRLAFAVEEPTQNVAQVRQRFDSCSTALQVLHGKDLHGRTALITGANCGIGYETARSLAHHGC 146
            :|..||.|..|.:..    ::.|.|.:.||..|...||.|:|..|||...|||.||||:||..|.
Worm     1 MDDELAEARGEGSGR----KREFHSRTNALDTLKEIDLSGKTYAITGTTSGIGIETARALALKGA 61

  Fly   147 EIIFACRNRSSAEAAIERIAQERPAARSRCRFAALDLSSLRSVQRFVEEIKQSVSHIDYLILNAG 211
            .::...||...:|...:||.:|:|..  :..|.:.||:||:|.:...:|.......:..||||||
Worm    62 HVVMFNRNIVESEKLKKRIEEEKPDV--KIDFISCDLNSLQSAKAAADEFLSKHWPLHGLILNAG 124

  Fly   212 VFALPYTRTVDGLETTFQVSHLSHFYLTLQLETLFDYKT--RIIVLSSESHRFANLPVE---NLA 271
            |||.....|.|..|:.|.|:||:.|.|..:|.......:  ||:.:||.|.....|..|   :..
Worm   125 VFAPTVKFTFDNFESHFGVNHLAQFLLAKELLPALRQSSPARIVFVSSVSSSHTGLKAEMTRSEK 189

  Fly   272 VHHLSP--PPEKYWSMMAYNNAKLCNVLFAQEL-AQRWKQRGISVFSLHPGNMVSSDL 326
            ::.|.|  ..|.|:.:.||  :|:|.||.|.:: ...:...|||.:::|||.|:.:.:
Worm   190 LNKLCPENANEFYYKLYAY--SKMCQVLTAFKIHRDEFVSHGISTYAIHPGTMIGTGI 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_001285735.1	WW	13..43	CDD:197736
		WW	54..86	CDD:197736	1/3 (33%)
		PRK06196	104..402	CDD:235736	80/231 (35%)
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	73/214 (34%)
F32A5.8	NP_495516.2	NADB_Rossmann	36..>245	CDD:304358	73/212 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1208
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56334
Inparanoid	1	1.050	174	1.000	Inparanoid score	I2710
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386905at33208
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	1	1.000	-	-		otm14313
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	1	1.100	-	-	O	PTHR24320
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830