DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wwox and rdh14b

DIOPT Version :9

Sequence 1:	NP_001285735.1	Gene:	Wwox / 34090	FlyBaseID:	FBgn0031972	Length:	409	Species:	Drosophila melanogaster
Sequence 2:	NP_001040655.1	Gene:	rdh14b / 334665	ZFINID:	ZDB-GENE-030131-6605	Length:	323	Species:	Danio rerio

Alignment Length:	298	Identity:	105/298 - (35%)
Similarity:	160/298 - (53%)	Gaps:	33/298 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 LHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAALDL 183
            :.|:|.::||||||||..||..|......:|.|||:|..||.|...|..:...::.......|||
Zfish    39 MRGKTVIVTGANCGIGKATAAELLKLQARVIMACRDRQRAEDAARDIQNQAGTSQGEIVIKHLDL 103

  Fly   184 SSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLTLQLETLFDY 248
            :||:||:||.||:.:....||.||.|||::..||::|.:|.|....|:||.||.||..|..|...
Zfish   104 ASLQSVRRFCEEVIREEPRIDVLINNAGLYQCPYSKTEEGFEMQLGVNHLGHFLLTNLLLDLLKQ 168

  Fly   249 K--TRIIVLSSESHRFANLPVENLAVHHLSPPPEKYWSMMAYNNAKLCNVLFAQELAQRWKQRGI 311
            .  :|::|:||:.:::.::..|:|      ...:.|.....|:.:||.|:||.:|||:|.....:
Zfish   169 SSPSRVVVVSSKLYKYGSINFEDL------NSEQSYNKSFCYSQSKLANLLFTRELARRLDGTEV 227

  Fly   312 SVFSLHPGNMVSSDLSRN----------YWFYRLLFAIVRPFTKSLQQAAATSIYCATANELTGL 366
            :|.:|.|| :|.:.|.|:          :|....|      |.||..:.|.|.:|.|.:.|:.|:
Zfish   228 TVNALTPG-IVRTRLGRHVNIPLLIKPLFWLVSWL------FFKSPLEGAQTPLYLACSPEVEGV 285

  Fly   367 SGLYFNNCFFCEPSKLSKS----AALQQQLWKLSENLI 400
            ||..|.||.  |...|||:    ||  ::||.|||:::
Zfish   286 SGKCFANCE--EEQLLSKATDDHAA--KRLWDLSESMV 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_001285735.1	WW	13..43	CDD:197736
		WW	54..86	CDD:197736
		PRK06196	104..402	CDD:235736	105/298 (35%)
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	105/296 (35%)
rdh14b	NP_001040655.1	PRK06197	41..322	CDD:235737	105/296 (35%)
rdh14b	NP_001040655.1	NADB_Rossmann	41..315	CDD:304358	102/290 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.710