Protein Alignment Wwox and rdh14b

DIOPT Version :10

• Sequence 1: NP_609171.1
• Gene: Wwox / 34090
• FlyBaseID: FBgn0031972
• Length: 409
• Species: Drosophila melanogaster
• Sequence 2: NP_001040655.1
• Gene: rdh14b / 334665
• ZFINID: ZDB-GENE-030131-6605
• Length: 323
• Species: Danio rerio
• Alignment Length: 298
• Identity: 105/298 - (35%)
• Similarity: 160/298 - (53%)
• Gaps: 33/298 - (11%)

  Fly   119 LHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAALDL 183
            :.|:|.::||||||||..||..|......:|.|||:|..||.|...|..:...::.......|||
Zfish    39 MRGKTVIVTGANCGIGKATAAELLKLQARVIMACRDRQRAEDAARDIQNQAGTSQGEIVIKHLDL 103

  Fly   184 SSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLTLQLETLFDY 248
            :||:||:||.||:.:....||.||.|||::..||::|.:|.|....|:||.||.||..|..|...
Zfish   104 ASLQSVRRFCEEVIREEPRIDVLINNAGLYQCPYSKTEEGFEMQLGVNHLGHFLLTNLLLDLLKQ 168

  Fly   249 K--TRIIVLSSESHRFANLPVENLAVHHLSPPPEKYWSMMAYNNAKLCNVLFAQELAQRWKQRGI 311
            .  :|::|:||:.:::.::..|:|      ...:.|.....|:.:||.|:||.:|||:|.....:
Zfish   169 SSPSRVVVVSSKLYKYGSINFEDL------NSEQSYNKSFCYSQSKLANLLFTRELARRLDGTEV 227

  Fly   312 SVFSLHPGNMVSSDLSRN----------YWFYRLLFAIVRPFTKSLQQAAATSIYCATANELTGL 366
            :|.:|.|| :|.:.|.|:          :|....|      |.||..:.|.|.:|.|.:.|:.|:
Zfish   228 TVNALTPG-IVRTRLGRHVNIPLLIKPLFWLVSWL------FFKSPLEGAQTPLYLACSPEVEGV 285

  Fly   367 SGLYFNNCFFCEPSKLSKS----AALQQQLWKLSENLI 400
            ||..|.||.  |...|||:    ||  ::||.|||:::
Zfish   286 SGKCFANCE--EEQLLSKATDDHAA--KRLWDLSESMV 319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wwox	NP_609171.1	WW	13..43	CDD:197736
		human_WWOX_like_SDR_c-like	121..402	CDD:187669	105/296 (35%)
rdh14b	NP_001040655.1	Rossmann-fold NAD(P)(+)-binding proteins	41..315	CDD:473865	102/290 (35%)